EIF4A2: Difference between revisions

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| image = 
| image_source = 
| PDB =
| Name = Eukaryotic translation initiation factor 4A, isoform 2
| HGNCid = 3284
| Symbol = EIF4A2
| AltSymbols =; EIF4A; BM-010; DDX2B; EIF4F
| OMIM = 601102
| ECnumber = 
| Homologene = 1487
| MGIid = 106906
| GeneAtlas_image1 = PBB_GE_EIF4A2_200912_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1974
    | Hs_Ensembl = ENSG00000156976
    | Hs_RefseqProtein = NP_001958
    | Hs_RefseqmRNA = NM_001967
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 187984060
    | Hs_GenLoc_end = 187990377
    | Hs_Uniprot = Q14240
    | Mm_EntrezGene = 13682
    | Mm_Ensembl = ENSMUSG00000022884
    | Mm_RefseqmRNA = NM_013506
    | Mm_RefseqProtein = NP_038534
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 23023090
    | Mm_GenLoc_end = 23029280
    | Mm_Uniprot = Q52KC1
  }}
}}
'''Eukaryotic translation initiation factor 4A, isoform 2''', also known as '''EIF4A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1974| accessdate = }}</ref>


{{Infobox_gene}}
'''Eukaryotic initiation factor 4A-II''' is a [[protein]] that in humans is encoded by the ''EIF4A2'' [[gene]].<ref name="pmid8521730">{{cite journal | vauthors = Sudo K, Takahashi E, Nakamura Y | title = Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2 | journal = Cytogenet Cell Genet | volume = 71 | issue = 4 | pages = 385–8 |date=Jan 1996 | pmid = 8521730 | pmc =  | doi =10.1159/000134145  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1974| accessdate = }}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Sudo K, Takahashi E, Nakamura Y |title=Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 4 |pages= 385-8 |year= 1996 |pmid= 8521730 |doi= }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=Akira  | last5=Sugano  | first5=Sumio }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Li W, Belsham GJ, Proud CG |title=Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29111–5 |year= 2001 |pmid= 11408474 |doi= 10.1074/jbc.C100284200 }}
*{{cite journal  | author=Li W, Belsham GJ, Proud CG |title=Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29111-5 |year= 2001 |pmid= 11408474 |doi= 10.1074/jbc.C100284200 }}
*{{cite journal  | vauthors=Kyono K, Miyashiro M, Taguchi I |title=Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 3 |pages= 659–66 |year= 2002 |pmid= 11922617 |doi= 10.1006/bbrc.2002.6702 }}
*{{cite journal  | author=Kyono K, Miyashiro M, Taguchi I |title=Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 3 |pages= 659-66 |year= 2002 |pmid= 11922617 |doi= 10.1006/bbrc.2002.6702 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Sarkar M |title=Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis |journal=FEBS Lett. |volume=579 |issue= 16 |pages= 3449–60 |year= 2005 |pmid= 15946665 |doi= 10.1016/j.febslet.2005.05.012 |name-list-format=vanc| author2=Das S  | author3=Bandyopadhaya A  | display-authors=3  | last4=Ray  | first4=K  | last5=Chaudhuri  | first5=K }}
*{{cite journal  | author=Sarkar M, Das S, Bandyopadhaya A, ''et al.'' |title=Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis. |journal=FEBS Lett. |volume=579 |issue= 16 |pages= 3449-60 |year= 2005 |pmid= 15946665 |doi= 10.1016/j.febslet.2005.05.012 }}
*{{cite journal  | vauthors=Feng P, Everly DN, Read GS |title=mRNA Decay during Herpes Simplex Virus (HSV) Infections: Protein-Protein Interactions Involving the HSV Virion Host Shutoff Protein and Translation Factors eIF4H and eIF4A |journal=J. Virol. |volume=79 |issue= 15 |pages= 9651–64 |year= 2005 |pmid= 16014927 |doi= 10.1128/JVI.79.15.9651-9664.2005 | pmc=1181552 }}
*{{cite journal  | author=Feng P, Everly DN, Read GS |title=mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. |journal=J. Virol. |volume=79 |issue= 15 |pages= 9651-64 |year= 2005 |pmid= 16014927 |doi= 10.1128/JVI.79.15.9651-9664.2005 }}
*{{cite journal  | author=Cheyssac C |title=EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families |journal=Diabetes |volume=55 |issue= 4 |pages= 1171–6 |year= 2006 |pmid= 16567544 |doi=10.2337/diabetes.55.04.06.db05-1298  |name-list-format=vanc| author2=Dina C  | author3=Leprêtre F  | display-authors=3  | last4=Vasseur-Delannoy  | first4=V  | last5=Dechaume  | first5=A  | last6=Lobbens  | first6=S  | last7=Balkau  | first7=B  | last8=Ruiz  | first8=J  | last9=Charpentier  | first9=G }}
*{{cite journal  | author=Cheyssac C, Dina C, Leprêtre F, ''et al.'' |title=EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families. |journal=Diabetes |volume=55 |issue= 4 |pages= 1171-6 |year= 2006 |pmid= 16567544 |doi=  }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor  | first9=Liam }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Initiation factors}}
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Latest revision as of 15:29, 13 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.[1][2]


References

  1. ↑ Sudo K, Takahashi E, Nakamura Y (Jan 1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2". Cytogenet Cell Genet. 71 (4): 385–8. doi:10.1159/000134145. PMID 8521730.
  2. ↑ "Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2".

Further reading



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