EIF3G: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 3 subunit G''' ('''eIF3g''') is a [[protein]] that in humans is encoded by the ''EIF3G'' [[gene]].<ref name="pmid9822659">{{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8  | date = December 1998 | pmid = 9822659 | pmc =  | doi = 10.1074/jbc.273.48.31901 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: EIF3S4 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8666| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_EIF3S4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cq0.
| PDB = {{PDB2|2cq0}}
| Name = Eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
| HGNCid = 3274
| Symbol = EIF3S4
| AltSymbols =; EIF3-P42; eIF3-delta; eIF3-p44; eIF3g
| OMIM = 603913
| ECnumber = 
| Homologene = 2784
| MGIid = 1858258
| GeneAtlas_image1 = PBB_GE_EIF3S4_208887_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8666
    | Hs_Ensembl = ENSG00000130811
    | Hs_RefseqProtein = NP_003746
    | Hs_RefseqmRNA = NM_003755
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 10086691
    | Hs_GenLoc_end = 10091585
    | Hs_Uniprot = O75821
    | Mm_EntrezGene = 53356
    | Mm_Ensembl = ENSMUSG00000070319
    | Mm_RefseqmRNA = NM_016876
    | Mm_RefseqProtein = NP_058572
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 20645035
    | Mm_GenLoc_end = 20648965
    | Mm_Uniprot = Q3THA0
  }}
}}
'''Eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa''', also known as '''EIF3S4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF3S4 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8666| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
EIF3G has been shown to [[Protein-protein interaction|interact]] with [[Band 4.1]],<ref name=pmid10887144>{{cite journal | vauthors = Hou CL, ((Tang Cj)), Roffler SR, Tang TK | title = Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus | journal = Blood | volume = 96 | issue = 2 | pages = 747–53 | date = July 2000 | pmid = 10887144 }}</ref> [[EIF3C]]<ref name=pmid9822659 /><ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> and [[EIF3A]].<ref name=pmid9822659/><ref name=pmid14519125>{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9  | date = October 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== See also ==
{{reflist|2}}
*[[Eukaryotic initiation factor 3|Eukaryotic initiation factor 3 (eIF3)]]
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal  | author=Asano K, Kinzy TG, Merrick WC, Hershey JW |title=Conservation and diversity of eukaryotic translation initiation factor eIF3. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1101-9 |year= 1997 |pmid= 8995409 |doi=  }}
*{{cite journal  | author=Méthot N, Rom E, Olsen H, Sonenberg N |title=The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1110-6 |year= 1997 |pmid= 8995410 |doi=  }}
*{{cite journal  | author=Block KL, Vornlocher HP, Hershey JW |title=Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31901-8 |year= 1998 |pmid= 9822659 |doi=  }}
*{{cite journal  | author=Bandyopadhyay A, Maitra U |title=Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells. |journal=Nucleic Acids Res. |volume=27 |issue= 5 |pages= 1331-7 |year= 1999 |pmid= 9973622 |doi=  }}
*{{cite journal  | author=Hou CL, Tang C, Roffler SR, Tang TK |title=Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus. |journal=Blood |volume=96 |issue= 2 |pages= 747-53 |year= 2000 |pmid= 10887144 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mayeur GL, Fraser CS, Peiretti F, ''et al.'' |title=Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. |journal=Eur. J. Biochem. |volume=270 |issue= 20 |pages= 4133-9 |year= 2003 |pmid= 14519125 |doi=  }}
*{{cite journal  | author=Fraser CS, Lee JY, Mayeur GL, ''et al.'' |title=The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8946-56 |year= 2004 |pmid= 14688252 |doi= 10.1074/jbc.M312745200 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Ogawa F, Kasai M, Akiyama T |title=A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 2 |pages= 771-6 |year= 2006 |pmid= 16243297 |doi= 10.1016/j.bbrc.2005.10.013 }}
*{{cite journal  | author=Kim JT, Kim KD, Song EY, ''et al.'' |title=Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g). |journal=FEBS Lett. |volume=580 |issue= 27 |pages= 6375-83 |year= 2007 |pmid= 17094969 |doi= 10.1016/j.febslet.2006.10.049 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}


{{gene-19-stub}}
== References ==
{{WikiDoc Sources}}
{{Reflist}}
 
== Further reading ==
{{Refbegin| 2}}
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
* {{cite journal | vauthors = Asano K, Kinzy TG, Merrick WC, Hershey JW | title = Conservation and diversity of eukaryotic translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1101–9 | year = 1997 | pmid = 8995409 | doi = 10.1074/jbc.272.2.1101 }}
* {{cite journal | vauthors = Méthot N, Rom E, Olsen H, Sonenberg N | title = The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1110–6 | year = 1997 | pmid = 8995410 | doi = 10.1074/jbc.272.2.1110 }}
* {{cite journal | vauthors = Bandyopadhyay A, Maitra U | title = Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells | journal = Nucleic Acids Res. | volume = 27 | issue = 5 | pages = 1331–7 | year = 1999 | pmid = 9973622 | pmc = 148320 | doi = 10.1093/nar/27.5.1331 }}
* {{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9 | year = 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}
* {{cite journal | vauthors = Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW | title = The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 8946–56 | year = 2004 | pmid = 14688252 | doi = 10.1074/jbc.M312745200 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1315–23 | year = 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Ogawa F, Kasai M, Akiyama T | title = A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3 | journal = Biochem. Biophys. Res. Commun. | volume = 338 | issue = 2 | pages = 771–6 | year = 2005 | pmid = 16243297 | doi = 10.1016/j.bbrc.2005.10.013 }}
* {{cite journal | vauthors = Kim JT, Kim KD, Song EY, Lee HG, Kim JW, Kim JW, Chae SK, Kim E, Lee MS, Yang Y, Lim JS | title = Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g) | journal = FEBS Lett. | volume = 580 | issue = 27 | pages = 6375–83 | year = 2006 | pmid = 17094969 | doi = 10.1016/j.febslet.2006.10.049 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
{{Refend}}
 
{{PDB Gallery|geneid=8666}}
 
{{Initiation factors}}
 
 
{{Gene-19-stub}}

Latest revision as of 03:42, 3 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.[1][2]

Interactions

EIF3G has been shown to interact with Band 4.1,[3] EIF3C[1][4] and EIF3A.[1][5]

See also

References

  1. ↑ 1.0 1.1 1.2 Block KL, Vornlocher HP, Hershey JW (December 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.
  2. ↑ "Entrez Gene: EIF3S4 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa".
  3. ↑ Hou CL, Tang Cj, Roffler SR, Tang TK (July 2000). "Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus". Blood. 96 (2): 747–53. PMID 10887144.
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.

Further reading


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