EIF3D: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 3 subunit D''' ('''eIF3d''') is a [[protein]] that in humans is encoded by the ''EIF3D'' [[gene]].<ref name="pmid9341143">{{cite journal | vauthors = Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW | title = Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27042–52  | date = Nov 1997 | pmid = 9341143 | pmc =  | doi = 10.1074/jbc.272.43.27042 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8664| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa
| HGNCid = 3278
| Symbol = EIF3S7
| AltSymbols =; MGC126526; MGC17258; eIF3-p66; eIF3-zeta; eIF3d
| OMIM = 603915
| ECnumber = 
| Homologene = 2782
| MGIid = 1933181
| GeneAtlas_image1 = PBB_GE_EIF3S7_200005_at_tn.png
| Function = {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005852 |text = eukaryotic translation initiation factor 3 complex}}
| Process = {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8664
    | Hs_Ensembl = ENSG00000100353
    | Hs_RefseqProtein = NP_003744
    | Hs_RefseqmRNA = NM_003753
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 35236844
    | Hs_GenLoc_end = 35255429
    | Hs_Uniprot = O15371
    | Mm_EntrezGene = 55944
    | Mm_Ensembl = ENSMUSG00000016554
    | Mm_RefseqmRNA = NM_018749
    | Mm_RefseqProtein = NP_061219
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 77786756
    | Mm_GenLoc_end = 77795834
    | Mm_Uniprot = O70194
  }}
}}
'''Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa''', also known as '''EIF3S7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8664| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Eukaryotic translation initiation factor-3 (eIF3), the largest of the [[Eukaryotic initiation factor|eIFs]], is a [[multiprotein complex]] composed of at least ten nonidentical subunits. The complex binds to the [[40S|40S ribosome]] and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the [[ternary complex]] of eIF2/GTP/methionyl-tRNA, and by promoting [[messenger RNA|mRNA]] binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.<ref name="entrez">{{cite web | title = Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8664| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
EIF3D has been shown to [[Protein-protein interaction|interact]] with [[PHLDA1]]<ref name=pmid11369516>{{cite journal | vauthors = Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D | title = Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product | journal = Cell. Signal. | volume = 13 | issue = 5 | pages = 345–52  | date = May 2001 | pmid = 11369516 | doi = 10.1016/S0898-6568(01)00141-3 }}</ref> and [[EIF3A]].<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name=pmid14519125>{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9  | date = Oct 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}</ref><ref name=pmid9822659>{{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8  | date = Nov 1998 | pmid = 9822659 | doi = 10.1074/jbc.273.48.31901 }}</ref>
 
== See also ==
*[[Eukaryotic initiation factor 3|Eukaryotic initiation factor 3 (eIF3)]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Asano K, Kinzy TG, Merrick WC, Hershey JW | title = Conservation and diversity of eukaryotic translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1101–9 | year = 1997 | pmid = 8995409 | doi = 10.1074/jbc.272.2.1101 }}
| citations =
* {{cite journal | vauthors = Méthot N, Rom E, Olsen H, Sonenberg N | title = The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1110–6 | year = 1997 | pmid = 8995410 | doi = 10.1074/jbc.272.2.1110 }}
*{{cite journal | author=Asano K, Kinzy TG, Merrick WC, Hershey JW |title=Conservation and diversity of eukaryotic translation initiation factor eIF3. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1101-9 |year= 1997 |pmid= 8995409 |doi= }}
* {{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8 | year = 1998 | pmid = 9822659 | doi = 10.1074/jbc.273.48.31901 }}
*{{cite journal | author=Méthot N, Rom E, Olsen H, Sonenberg N |title=The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1110-6 |year= 1997 |pmid= 8995410 |doi= }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal  | author=Asano K, Vornlocher HP, Richter-Cook NJ, ''et al.'' |title=Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27042-52 |year= 1997 |pmid= 9341143 |doi=  }}
* {{cite journal | vauthors = Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, Donahue TF, Hinnebusch AG | title = Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2326–37 | year = 2001 | pmid = 11331597 | pmc = 125443 | doi = 10.1093/emboj/20.9.2326 }}
*{{cite journal | author=Block KL, Vornlocher HP, Hershey JW |title=Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31901-8 |year= 1998 |pmid= 9822659 |doi= }}
* {{cite journal | vauthors = Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D | title = Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product | journal = Cell. Signal. | volume = 13 | issue = 5 | pages = 345–52 | year = 2001 | pmid = 11369516 | doi = 10.1016/S0898-6568(01)00141-3 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P | title = The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3 | journal = J. Biol. Chem. | volume = 276 | issue = 49 | pages = 45988–95 | year = 2001 | pmid = 11590142 | doi = 10.1074/jbc.M104966200 }}
*{{cite journal | author=Asano K, Shalev A, Phan L, ''et al.'' |title=Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2326-37 |year= 2001 |pmid= 11331597 |doi= 10.1093/emboj/20.9.2326 }}
* {{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9 | year = 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}
*{{cite journal | author=Hinz T, Flindt S, Marx A, ''et al.'' |title=Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. |journal=Cell. Signal. |volume=13 |issue= 5 |pages= 345-52 |year= 2001 |pmid= 11369516 |doi= }}
* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2004 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Morris-Desbois C, Réty S, Ferro M, ''et al.'' |title=The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 45988-95 |year= 2002 |pmid= 11590142 |doi= 10.1074/jbc.M104966200 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Mayeur GL, Fraser CS, Peiretti F, ''et al.'' |title=Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. |journal=Eur. J. Biochem. |volume=270 |issue= 20 |pages= 4133-9 |year= 2003 |pmid= 14519125 |doi= }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}
{{Initiation factors}}


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{{gene-22-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:28, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.[1][2]

Function

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.[2]

Interactions

EIF3D has been shown to interact with PHLDA1[3] and EIF3A.[4][5][6]

See also

References

  1. ↑ Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (Nov 1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J. Biol. Chem. 272 (43): 27042–52. doi:10.1074/jbc.272.43.27042. PMID 9341143.
  2. ↑ 2.0 2.1 "Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa".
  3. ↑ Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.
  4. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  6. ↑ Block KL, Vornlocher HP, Hershey JW (Nov 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.

Further reading


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