EIF2B3: Difference between revisions

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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
| HGNCid = 3259
| Symbol = EIF2B3
| AltSymbols =; EIF-2B; EIF2Bgamma
| OMIM = 606273
| ECnumber = 
| Homologene = 7005
| MGIid = 1313286
| GeneAtlas_image1 = PBB_GE_EIF2B3_218488_at_tn.png
| Function = {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016779 |text = nucleotidyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005851 |text = eukaryotic translation initiation factor 2B complex}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}} {{GNF_GO|id=GO:0009058 |text = biosynthetic process}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0009749 |text = response to glucose stimulus}} {{GNF_GO|id=GO:0014003 |text = oligodendrocyte development}} {{GNF_GO|id=GO:0043434 |text = response to peptide hormone stimulus}} {{GNF_GO|id=GO:0051716 |text = cellular response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8891
    | Hs_Ensembl = ENSG00000070785
    | Hs_RefseqProtein = NP_065098
    | Hs_RefseqmRNA = NM_020365
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 45089037
    | Hs_GenLoc_end = 45224869
    | Hs_Uniprot = Q9NR50
    | Mm_EntrezGene = 108067
    | Mm_Ensembl = ENSMUSG00000028683
    | Mm_RefseqmRNA = XM_131572
    | Mm_RefseqProtein = XP_131572
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 116520097
    | Mm_GenLoc_end = 116568855
    | Mm_Uniprot = 
  }}
}}
'''Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa''', also known as '''EIF2B3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8891| accessdate = }}</ref>


{{Infobox_gene}}
'''Translation initiation factor eIF-2B subunit gamma''' is a [[protein]] that in humans is encoded by the ''EIF2B3'' [[gene]].<ref name="pmid10900014">{{cite journal | vauthors = Kruger M, Beger C, Li QX, Welch PJ, Tritz R, Leavitt M, Barber JR, Wong-Staal F | title = Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 15 | pages = 8566–71 |date=Aug 2000 | pmid = 10900014 | pmc = 26988 | doi =10.1073/pnas.97.15.8566  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8891| accessdate = }}</ref>
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Welsh GI, Miyamoto S, Price NT, ''et al.'' |title=T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11410-3 |year= 1996 |pmid= 8626696 |doi=  }}
*{{cite journal  | vauthors=Welsh GI, Miyamoto S, Price NT |title=T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11410–3 |year= 1996 |pmid= 8626696 |doi=10.1074/jbc.271.19.11410 |display-authors=etal}}
*{{cite journal  | author=Gomez E, Pavitt GD |title=Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3965-76 |year= 2000 |pmid= 10805739 |doi= }}
*{{cite journal  | vauthors=Gomez E, Pavitt GD |title=Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3965–76 |year= 2000 |pmid= 10805739 |doi=10.1128/MCB.20.11.3965-3976.2000  | pmc=85753  }}
*{{cite journal  | author=Anthony TG, Fabian JR, Kimball SR, Jefferson LS |title=Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 56-62 |year= 2000 |pmid= 10858531 |doi=  }}
*{{cite journal  | vauthors=Anthony TG, Fabian JR, Kimball SR, Jefferson LS |title=Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 56–62 |year= 2000 |pmid= 10858531 |doi=  10.1016/S0167-4781(00)00062-2}}
*{{cite journal  | author=Kruger M, Beger C, Li QX, ''et al.'' |title=Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8566-71 |year= 2000 |pmid= 10900014 |doi= }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Williams DD, Price NT, Loughlin AJ, Proud CG |title=Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24697–703 |year= 2001 |pmid= 11323413 |doi= 10.1074/jbc.M011788200 }}
*{{cite journal  | author=Williams DD, Price NT, Loughlin AJ, Proud CG |title=Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24697-703 |year= 2001 |pmid= 11323413 |doi= 10.1074/jbc.M011788200 }}
*{{cite journal  | vauthors=van der Knaap MS, Leegwater PA, Könst AA |title=Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. |journal=Ann. Neurol. |volume=51 |issue= 2 |pages= 264–70 |year= 2002 |pmid= 11835386 |doi=10.1002/ana.10112  |display-authors=etal}}
*{{cite journal  | author=van der Knaap MS, Leegwater PA, Könst AA, ''et al.'' |title=Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. |journal=Ann. Neurol. |volume=51 |issue= 2 |pages= 264-70 |year= 2002 |pmid= 11835386 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Fogli A, Dionisi-Vici C, Deodato F |title=A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. |journal=Neurology |volume=59 |issue= 12 |pages= 1966–8 |year= 2003 |pmid= 12499492 |doi= 10.1212/01.wnl.0000041666.76863.47|display-authors=etal}}
*{{cite journal  | author=Fogli A, Dionisi-Vici C, Deodato F, ''et al.'' |title=A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. |journal=Neurology |volume=59 |issue= 12 |pages= 1966-8 |year= 2003 |pmid= 12499492 |doi=  }}
*{{cite journal  | vauthors=Fogli A, Rodriguez D, Eymard-Pierre E |title=Ovarian failure related to eukaryotic initiation factor 2B mutations. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1544–50 |year= 2003 |pmid= 12707859 |doi=10.1086/375404 | pmc=1180314  |display-authors=etal}}
*{{cite journal  | author=Fogli A, Rodriguez D, Eymard-Pierre E, ''et al.'' |title=Ovarian failure related to eukaryotic initiation factor 2B mutations. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1544-50 |year= 2003 |pmid= 12707859 |doi= }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Fogli A, Schiffmann R, Hugendubler L |title=Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. |journal=Eur. J. Hum. Genet. |volume=12 |issue= 7 |pages= 561–6 |year= 2005 |pmid= 15054402 |doi= 10.1038/sj.ejhg.5201189 |display-authors=etal}}
*{{cite journal  | author=Fogli A, Schiffmann R, Hugendubler L, ''et al.'' |title=Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. |journal=Eur. J. Hum. Genet. |volume=12 |issue= 7 |pages= 561-6 |year= 2005 |pmid= 15054402 |doi= 10.1038/sj.ejhg.5201189 }}
*{{cite journal  | vauthors=Li W, Wang X, Van Der Knaap MS, Proud CG |title=Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3295–306 |year= 2004 |pmid= 15060152 |doi=10.1128/MCB.24.8.3295-3306.2004  | pmc=381664  }}
*{{cite journal  | author=Li W, Wang X, Van Der Knaap MS, Proud CG |title=Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3295-306 |year= 2004 |pmid= 15060152 |doi=  }}
*{{cite journal  | vauthors=Van Haren K, van der Voorn JP, Peterson DR |title=The life and death of oligodendrocytes in vanishing white matter disease. |journal=J. Neuropathol. Exp. Neurol. |volume=63 |issue= 6 |pages= 618–30 |year= 2004 |pmid= 15217090 |doi=  |display-authors=etal}}
*{{cite journal  | author=Van Haren K, van der Voorn JP, Peterson DR, ''et al.'' |title=The life and death of oligodendrocytes in vanishing white matter disease. |journal=J. Neuropathol. Exp. Neurol. |volume=63 |issue= 6 |pages= 618-30 |year= 2004 |pmid= 15217090 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV |title=Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1766–72 |year= 2006 |pmid= 16288713 |doi= 10.1016/j.bbrc.2005.10.150 }}
*{{cite journal  | author=Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV |title=Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1766-72 |year= 2006 |pmid= 16288713 |doi= 10.1016/j.bbrc.2005.10.150 }}
*{{cite journal  | vauthors=Mikami S, Masutani M, Sonenberg N |title=An efficient mammalian cell-free translation system supplemented with translation factors. |journal=Protein Expr. Purif. |volume=46 |issue= 2 |pages= 348–57 |year= 2006 |pmid= 16289705 |doi= 10.1016/j.pep.2005.09.021 |display-authors=etal}}
*{{cite journal  | author=Mikami S, Masutani M, Sonenberg N, ''et al.'' |title=An efficient mammalian cell-free translation system supplemented with translation factors. |journal=Protein Expr. Purif. |volume=46 |issue= 2 |pages= 348-57 |year= 2006 |pmid= 16289705 |doi= 10.1016/j.pep.2005.09.021 }}
}}
}}
{{refend}}
{{refend}}


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{{Genetic translation}}
 
 
{{gene-1-stub}}

Latest revision as of 15:28, 13 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.[1][2]

References

  1. ↑ Kruger M, Beger C, Li QX, Welch PJ, Tritz R, Leavitt M, Barber JR, Wong-Staal F (Aug 2000). "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach". Proc Natl Acad Sci U S A. 97 (15): 8566–71. doi:10.1073/pnas.97.15.8566. PMC 26988. PMID 10900014.
  2. ↑ "Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa".

Further reading



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