EEF1A2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Elongation factor 1-alpha 2''' is a [[protein]] that in humans is encoded by the ''EEF1A2'' [[gene]].<ref name="pmid8354261">{{cite journal | vauthors = Knudsen SM, Frydenberg J, Clark BF, Leffers H | title = Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha | journal = Eur J Biochem | volume = 215 | issue = 3 | pages = 549–54 | date = Sep 1993 | pmid = 8354261 | pmc =  | doi = 10.1111/j.1432-1033.1993.tb18064.x }}</ref><ref name="pmid8812466">{{cite journal | vauthors = Lund A, Knudsen SM, Vissing H, Clark B, Tommerup N | title = Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3 | journal = Genomics | volume = 36 | issue = 2 | pages = 359–61 | date = Jan 1997 | pmid = 8812466 | pmc = | doi = 10.1006/geno.1996.0475 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EEF1A2 eukaryotic translation elongation factor 1 alpha 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1917| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Eukaryotic translation elongation factor 1 alpha 2
| HGNCid = 3192
| Symbol = EEF1A2
| AltSymbols =; STN; EF1A; EEF1AL; EF-1-alpha-2; HS1
| OMIM = 602959
| ECnumber = 
| Homologene = 68213
| MGIid = 1096317
| GeneAtlas_image1 = PBB_GE_EEF1A2_204540_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003746 |text = translation elongation factor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005853 |text = eukaryotic translation elongation factor 1 complex}}
| Process = {{GNF_GO|id=GO:0006414 |text = translational elongation}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1917
    | Hs_Ensembl = ENSG00000101210
    | Hs_RefseqProtein = NP_001949
    | Hs_RefseqmRNA = NM_001958
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 61589810
    | Hs_GenLoc_end = 61600949
    | Hs_Uniprot = Q05639
    | Mm_EntrezGene = 13628
    | Mm_Ensembl = ENSMUSG00000016349
    | Mm_RefseqmRNA = NM_007906
    | Mm_RefseqProtein = NP_031932
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 181077098
    | Mm_GenLoc_end = 181086422
    | Mm_Uniprot = P62631
  }}
}}
'''Eukaryotic translation elongation factor 1 alpha 2''', also known as '''EEF1A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EEF1A2 eukaryotic translation elongation factor 1 alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1917| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes an isoform of the alpha subunit of the [[eEF-1|elongation factor-1]] complex, which is responsible for the enzymatic delivery of [[aminoacyl tRNA]]s to the [[ribosome]]. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas.
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.<ref name="entrez">{{cite web | title = Entrez Gene: EEF1A2 eukaryotic translation elongation factor 1 alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1917| accessdate = }}</ref>
 
}}
This gene may be critical in the development of [[ovarian cancer]].<ref name="entrez" />
 
== Regulation ==
 
EEF1A2 is a direct target of [[Mir-663 microRNA precursor family|miRNA-663]] and [[Mir-744 microRNA precursor family|miRNA-744]].<ref>{{cite journal | vauthors = Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I | title = Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744. | journal = British Journal of Cancer | volume = 108 | issue = 11 | pages = 2304–11 | date = 11 June 2013 | pmid = 23695020 | doi = 10.1038/bjc.2013.243 | url = http://www.nature.com/bjc/journal/v108/n11/full/bjc2013243a.html | pmc=3681015}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
{{Clear}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | author = Lee JM | title = The role of protein elongation factor eEF1A2 in ovarian cancer | journal = Reprod. Biol. Endocrinol. | volume = 1 | issue =  | pages = 69 | year = 2004 | pmid = 14588074 | pmc = 239897 | doi = 10.1186/1477-7827-1-69 }}
| citations =
* {{cite journal | author = Beh KJ | title = Immunoglobulin class specificity of non-agglutinating antibody produced in cattle following Brucella abortus 45/20 vaccination | journal = Aust. Vet. J. | volume = 51 | issue = 10 | pages = 481–3 | year = 1976 | pmid = 812466 | doi = 10.1111/j.1751-0813.1975.tb02385.x }}
*{{cite journal | author=Lee JM |title=The role of protein elongation factor eEF1A2 in ovarian cancer. |journal=Reprod. Biol. Endocrinol. |volume=1 |issue=  |pages= 69 |year= 2004 |pmid= 14588074 |doi= 10.1186/1477-7827-1-69 }}
* {{cite journal | vauthors = Lee S, Ann DK, Wang E | title = Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway | journal = Biochem. Biophys. Res. Commun. | volume = 203 | issue = 3 | pages = 1371–7 | year = 1994 | pmid = 7945283 | doi = 10.1006/bbrc.1994.2336 }}
*{{cite journal | author=Beh KJ |title=Immunoglobulin class specificity of non-agglutinating antibody produced in cattle following Brucella abortus 45/20 vaccination. |journal=Aust. Vet. J. |volume=51 |issue= 10 |pages= 481-3 |year= 1976 |pmid= 812466 |doi= }}
* {{cite journal | vauthors = Wu-Baer F, Lane WS, Gaynor RB | title = Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA | journal = J. Biol. Chem. | volume = 271 | issue = 8 | pages = 4201–8 | year = 1996 | pmid = 8626763 | doi = 10.1074/jbc.271.8.4201 }}
*{{cite journal | author=Lee S, Ann DK, Wang E |title=Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 3 |pages= 1371-7 |year= 1994 |pmid= 7945283 |doi= }}
* {{cite journal | vauthors = Bischoff C, Kahns S, Lund A, Jørgensen HF, Praestegaard M, Clark BF, Leffers H | title = The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity | journal = Genomics | volume = 68 | issue = 1 | pages = 63–70 | year = 2001 | pmid = 10950927 | doi = 10.1006/geno.2000.6271}}
*{{cite journal  | author=Knudsen SM, Frydenberg J, Clark BF, Leffers H |title=Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. |journal=Eur. J. Biochem. |volume=215 |issue= 3 |pages= 549-54 |year= 1993 |pmid= 8354261 |doi=  }}
* {{cite journal | vauthors = McClatchy DB, Knudsen CR, Clark BF, Kahn RA, Hall RA, Levey AI | title = Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2 | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 29268–74 | year = 2002 | pmid = 12048193 | doi = 10.1074/jbc.M203081200}}
*{{cite journal | author=Wu-Baer F, Lane WS, Gaynor RB |title=Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4201-8 |year= 1996 |pmid= 8626763 |doi=  }}
* {{cite journal | vauthors = Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM | title = Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer | journal = Nat. Genet. | volume = 31 | issue = 3 | pages = 301–5 | year = 2002 | pmid = 12053177 | doi = 10.1038/ng904}}
*{{cite journal  | author=Lund A, Knudsen SM, Vissing H, ''et al.'' |title=Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. |journal=Genomics |volume=36 |issue= 2 |pages= 359-61 |year= 1997 |pmid= 8812466 |doi= 10.1006/geno.1996.0475 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086}}
*{{cite journal | author=Bischoff C, Kahns S, Lund A, ''et al.'' |title=The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity. |journal=Genomics |volume=68 |issue= 1 |pages= 63-70 |year= 2001 |pmid= 10950927 |doi= 10.1006/geno.2000.6271 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046}}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207}}
*{{cite journal  | author=McClatchy DB, Knudsen CR, Clark BF, ''et al.'' |title=Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29268-74 |year= 2002 |pmid= 12048193 |doi= 10.1074/jbc.M203081200 }}
* {{cite journal | vauthors = Byun HM, Suh D, Jeong Y, Wee HS, Kim JM, Kim WK, Ko JJ, Kim JS, Lee YB, Oh YK | title = Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells | journal = Biochem. Biophys. Res. Commun. | volume = 332 | issue = 2 | pages = 518–23 | year = 2005 | pmid = 15893736 | doi = 10.1016/j.bbrc.2005.04.155}}
*{{cite journal | author=Anand N, Murthy S, Amann G, ''et al.'' |title=Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 301-5 |year= 2002 |pmid= 12053177 |doi= 10.1038/ng904 }}
* {{cite journal | vauthors = Ahmed M, Forsberg J, Bergsten P | title = Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry | journal = J. Proteome Res. | volume = 4 | issue = 3 | pages = 931–40 | year = 2005 | pmid = 15952740 | doi = 10.1021/pr050024a }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tomlinson VA, Newbery HJ, Wray NR, Jackson J, Larionov A, Miller WR, Dixon JM, Abbott CM | title = Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours | journal = BMC Cancer | volume = 5 | pages = 113 | year = 2006 | pmid = 16156888 | pmc = 1236916 | doi = 10.1186/1471-2407-5-113}}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
* {{cite journal | vauthors = Li R, Wang H, Bekele BN, Yin Z, Caraway NP, Katz RL, Stass SA, Jiang F | title = Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach | journal = Oncogene | volume = 25 | issue = 18 | pages = 2628–35 | year = 2006 | pmid = 16369491 | doi = 10.1038/sj.onc.1209289}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Byun HM, Suh D, Jeong Y, ''et al.'' |title=Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 2 |pages= 518-23 |year= 2005 |pmid= 15893736 |doi= 10.1016/j.bbrc.2005.04.155 }}
*{{cite journal | author=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931-40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a }}
*{{cite journal | author=Tomlinson VA, Newbery HJ, Wray NR, ''et al.'' |title=Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. |journal=BMC Cancer |volume=5 |issue=  |pages= 113 |year= 2006 |pmid= 16156888 |doi= 10.1186/1471-2407-5-113 }}
*{{cite journal | author=Li R, Wang H, Bekele BN, ''et al.'' |title=Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. |journal=Oncogene |volume=25 |issue= 18 |pages= 2628-35 |year= 2006 |pmid= 16369491 |doi= 10.1038/sj.onc.1209289 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Genetic translation}}
{{WikiDoc Sources}}
 
 
{{gene-20-stub}}

Latest revision as of 00:20, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.[1][2][3]

Function

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas.

Clinical significance

This gene may be critical in the development of ovarian cancer.[3]

Regulation

EEF1A2 is a direct target of miRNA-663 and miRNA-744.[4]

References

  1. ↑ Knudsen SM, Frydenberg J, Clark BF, Leffers H (Sep 1993). "Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha". Eur J Biochem. 215 (3): 549–54. doi:10.1111/j.1432-1033.1993.tb18064.x. PMID 8354261.
  2. ↑ Lund A, Knudsen SM, Vissing H, Clark B, Tommerup N (Jan 1997). "Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3". Genomics. 36 (2): 359–61. doi:10.1006/geno.1996.0475. PMID 8812466.
  3. ↑ 3.0 3.1 "Entrez Gene: EEF1A2 eukaryotic translation elongation factor 1 alpha 2".
  4. ↑ Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.

Further reading

  • Lee JM (2004). "The role of protein elongation factor eEF1A2 in ovarian cancer". Reprod. Biol. Endocrinol. 1: 69. doi:10.1186/1477-7827-1-69. PMC 239897. PMID 14588074.
  • Beh KJ (1976). "Immunoglobulin class specificity of non-agglutinating antibody produced in cattle following Brucella abortus 45/20 vaccination". Aust. Vet. J. 51 (10): 481–3. doi:10.1111/j.1751-0813.1975.tb02385.x. PMID 812466.
  • Lee S, Ann DK, Wang E (1994). "Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway". Biochem. Biophys. Res. Commun. 203 (3): 1371–7. doi:10.1006/bbrc.1994.2336. PMID 7945283.
  • Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". J. Biol. Chem. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
  • Bischoff C, Kahns S, Lund A, Jørgensen HF, Praestegaard M, Clark BF, Leffers H (2001). "The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity". Genomics. 68 (1): 63–70. doi:10.1006/geno.2000.6271. PMID 10950927.
  • McClatchy DB, Knudsen CR, Clark BF, Kahn RA, Hall RA, Levey AI (2002). "Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2". J. Biol. Chem. 277 (32): 29268–74. doi:10.1074/jbc.M203081200. PMID 12048193.
  • Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM (2002). "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer". Nat. Genet. 31 (3): 301–5. doi:10.1038/ng904. PMID 12053177.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Byun HM, Suh D, Jeong Y, Wee HS, Kim JM, Kim WK, Ko JJ, Kim JS, Lee YB, Oh YK (2005). "Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells". Biochem. Biophys. Res. Commun. 332 (2): 518–23. doi:10.1016/j.bbrc.2005.04.155. PMID 15893736.
  • Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.
  • Tomlinson VA, Newbery HJ, Wray NR, Jackson J, Larionov A, Miller WR, Dixon JM, Abbott CM (2006). "Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours". BMC Cancer. 5: 113. doi:10.1186/1471-2407-5-113. PMC 1236916. PMID 16156888.
  • Li R, Wang H, Bekele BN, Yin Z, Caraway NP, Katz RL, Stass SA, Jiang F (2006). "Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach". Oncogene. 25 (18): 2628–35. doi:10.1038/sj.onc.1209289. PMID 16369491.


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