ECGF1

Endothelial cell growth factor 1 (platelet-derived)
PDB rendering based on 1uou.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1uou​, 2j0f​
Identifiers
Symbols	ECGF1 ; MNGIE; PDECGF; TP; hPD-ECGF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1474
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Endothelial cell growth factor 1 (platelet-derived), also known as ECGF1, is a human gene.

Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.

Further reading

• Yang Q, Yoshimura G, Mori I; et al. (2002). "Thymidine phosphorylase and breast carcinoma". Anticancer Res. 22 (4): 2355–60. PMID 12174926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asai K, Nakanishi K, Isobe I; et al. (1992). "Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor". J. Biol. Chem. 267 (28): 20311–6. PMID 1400349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furukawa T, Yoshimura A, Sumizawa T; et al. (1992). "Angiogenic factor". Nature. 356 (6371): 668. doi:10.1038/356668a0. PMID 1570012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Usuki K, Saras J, Waltenberger J; et al. (1992). "Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity". Biochem. Biophys. Res. Commun. 184 (3): 1311–6. PMID 1590793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stenman G, Sahlin P, Dumanski JP; et al. (1992). "Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13". Cytogenet. Cell Genet. 59 (1): 22–3. PMID 1733667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hagiwara K, Stenman G, Honda H; et al. (1991). "Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene". Mol. Cell. Biol. 11 (4): 2125–32. PMID 2005900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishikawa F, Miyazono K, Hellman U; et al. (1989). "Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor". Nature. 338 (6216): 557–62. doi:10.1038/338557a0. PMID 2467210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bardosi A, Creutzfeldt W, DiMauro S; et al. (1987). "Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase. A new mitochondrial multisystem disorder". Acta Neuropathol. 74 (3): 248–58. PMID 2823522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyazono K, Okabe T, Urabe A; et al. (1987). "Purification and properties of an endothelial cell growth factor from human platelets". J. Biol. Chem. 262 (9): 4098–103. PMID 3549724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Usuki K, Gonez LJ, Wernstedt C; et al. (1994). "Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells". Biochim. Biophys. Acta. 1222 (3): 411–4. PMID 8038210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Hirano M, Silvestri G, Blake DM; et al. (1994). "Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder". Neurology. 44 (4): 721–7. PMID 8164833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stevenson DP, Milligan SR, Collins WP (1998). "Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis". Am. J. Pathol. 152 (6): 1641–6. PMID 9626068.CS1 maint: Multiple names: authors list (link)
• Nishino I, Spinazzola A, Hirano M (1999). "Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder". Science. 283 (5402): 689–92. PMID 9924029.CS1 maint: Multiple names: authors list (link)
• Asgari MM, Haggerty JG, McNiff JM; et al. (1999). "Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors". J. Cutan. Pathol. 26 (6): 287–94. PMID 10472757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sivridis E, Giatromanolaki A, Koukourakis MI; et al. (2000). "Thymidine phosphorylase expression in normal and hyperplastic endometrium". J. Clin. Pathol. 53 (9): 704–8. PMID 11041061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Komatsu T, Yamazaki H, Shimada N; et al. (2001). "Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver". Clin. Cancer Res. 7 (3): 675–81. PMID 11297264.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kojima H, Shijubo N, Abe S (2002). "Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma". Cancer. 94 (4): 1083–93. PMID 11920479.CS1 maint: Multiple names: authors list (link)