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{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor COE1''' is a [[protein]] that in humans is encoded by the ''EBF1'' [[gene]].
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EBF1 stands for '''Early B-Cell Factor 1'''.<ref>{{cite web|url = https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3126|title = Symbol Report: EBF1|website = HUGO Gene Nomenclature Committee }}</ref><ref name="pmid8012110">{{cite journal | vauthors = Milatovich A, Qiu RG, Grosschedl R, Francke U | title = Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11 | journal = Mamm. Genome | volume = 5 | issue = 4 | pages = 211–5  | date = Jul 1994 | pmid = 8012110 | pmc =  | doi = 10.1007/BF00360547 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EBF1 early B-cell factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1879| accessdate = }}</ref>
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EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.<ref>{{Cite journal|last=Treiber|first=Thomas|last2=Mandel|first2=Elizabeth M.|last3=Pott|first3=Sebastian|last4=Györy|first4=Ildiko|last5=Firner|first5=Sonja|last6=Liu|first6=Edison T.|last7=Grosschedl|first7=Rudolf|title=Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin|url=http://linkinghub.elsevier.com/retrieve/pii/S1074761310001627|journal=Immunity|volume=32|issue=5|pages=714–725|doi=10.1016/j.immuni.2010.04.013}}</ref><ref>{{Cite journal|last=Hagman|first=James|last2=Ramírez|first2=Julita|last3=Lukin|first3=Kara|date=2012-01-01|title=B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1|journal=Current Topics in Microbiology and Immunology|volume=356|pages=17–38|doi=10.1007/82_2011_139|issn=0070-217X|pmc=3925327|pmid=21735360}}</ref> The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.<ref>{{Cite journal|last=Schwartz|first=Anton M.|last2=Putlyaeva|first2=Lidia V.|last3=Covich|first3=Milica|last4=Klepikova|first4=Anna V.|last5=Akulich|first5=Kseniya A.|last6=Vorontsov|first6=Ilya E.|last7=Korneev|first7=Kirill V.|last8=Dmitriev|first8=Sergey E.|last9=Polanovsky|first9=Oleg L.|date=2016-10-01|title=Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells|url=http://www.sciencedirect.com/science/article/pii/S1874939916301365|journal=Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms|volume=1859|issue=10|pages=1259–1268|doi=10.1016/j.bbagrm.2016.07.004}}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Early B-cell factor 1
| HGNCid = 3126
| Symbol = EBF1
| AltSymbols =; COE1; EBF; O/E-1; OLF1
| OMIM = 164343
| ECnumber =
| Homologene = 7297
| MGIid = 95275
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1879
    | Hs_Ensembl = ENSG00000164330
    | Hs_RefseqProtein = NP_076870
    | Hs_RefseqmRNA = NM_024007
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 158058697
    | Hs_GenLoc_end = 158459064
    | Hs_Uniprot = Q9UH73
    | Mm_EntrezGene = 13591
    | Mm_Ensembl = ENSMUSG00000057098
    | Mm_RefseqmRNA = XM_977520
    | Mm_RefseqProtein = XP_982614
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 44460740
    | Mm_GenLoc_end = 44851514
    | Mm_Uniprot = Q3V317
  }}
}}
'''Early B-cell factor 1''', also known as '''EBF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EBF1 early B-cell factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1879| accessdate = }}</ref>


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== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
EBF1 has been shown to [[Protein-protein interaction|interact]] with [[ZNF423]]<ref name=pmid9151733>{{cite journal | vauthors = Tsai RY, Reed RR | title = Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development | journal = J. Neurosci. | volume = 17 | issue = 11 | pages = 4159–69  | date = Jun 1997 | pmid = 9151733 }}</ref> and [[CREB binding protein]].<ref name=pmid12748286>{{cite journal | vauthors = Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T | title = Inhibition of p300/CBP by early B-cell factor | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3837–46  | date = Jun 2003 | pmid = 12748286 | pmc = 155219 | doi = 10.1128/MCB.23.11.3837-3846.2003 | url = http://lup.lub.lu.se/search/ws/files/2814746/624799.pdf }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Liberg D, Sigvardsson M, Akerblad P | title = The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers | journal = Mol. Cell. Biol. | volume = 22 | issue = 24 | pages = 8389–97 | year = 2002 | pmid = 12446759 | pmc = 139877 | doi = 10.1128/MCB.22.24.8389-8397.2002 }}
| citations =
* {{cite journal | vauthors = Hagman J, Gutch MJ, Lin H, Grosschedl R | title = EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains | journal = EMBO J. | volume = 14 | issue = 12 | pages = 2907–16 | year = 1995 | pmid = 7796816 | pmc = 398409 | doi =  }}
*{{cite journal | author=Liberg D, Sigvardsson M, Akerblad P |title=The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers. |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8389-97 |year= 2003 |pmid= 12446759 |doi= }}
* {{cite journal | vauthors = Wang MM, Reed RR | title = Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast | journal = Nature | volume = 364 | issue = 6433 | pages = 121–6 | year = 1993 | pmid = 8321284 | doi = 10.1038/364121a0 }}
*{{cite journal | author=Hagman J, Gutch MJ, Lin H, Grosschedl R |title=EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains. |journal=EMBO J. |volume=14 |issue= 12 |pages= 2907-16 |year= 1995 |pmid= 7796816 |doi=  }}
* {{cite journal | vauthors = Hagman J, Belanger C, Travis A, Turck CW, Grosschedl R | title = Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression | journal = Genes Dev. | volume = 7 | issue = 5 | pages = 760–73 | year = 1993 | pmid = 8491377 | doi = 10.1101/gad.7.5.760 }}
*{{cite journal  | author=Milatovich A, Qiu RG, Grosschedl R, Francke U |title=Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11. |journal=Mamm. Genome |volume=5 |issue= 4 |pages= 211-5 |year= 1994 |pmid= 8012110 |doi=  }}
* {{cite journal | vauthors = Travis A, Hagman J, Hwang L, Grosschedl R | title = Purification of early-B-cell factor and characterization of its DNA-binding specificity | journal = Mol. Cell. Biol. | volume = 13 | issue = 6 | pages = 3392–400 | year = 1993 | pmid = 8497258 | pmc = 359803 | doi =  }}
*{{cite journal | author=Wang MM, Reed RR |title=Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast. |journal=Nature |volume=364 |issue= 6433 |pages= 121-6 |year= 1993 |pmid= 8321284 |doi= 10.1038/364121a0 }}
* {{cite journal | vauthors = Tsai RY, Reed RR | title = Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development | journal = J. Neurosci. | volume = 17 | issue = 11 | pages = 4159–69 | year = 1997 | pmid = 9151733 | doi =  }}
*{{cite journal | author=Hagman J, Belanger C, Travis A, ''et al.'' |title=Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. |journal=Genes Dev. |volume=7 |issue= 5 |pages= 760-73 |year= 1993 |pmid= 8491377 |doi= }}
* {{cite journal | vauthors = Gisler R, Jacobsen SE, Sigvardsson M | title = Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse | journal = Blood | volume = 96 | issue = 4 | pages = 1457–64 | year = 2000 | pmid = 10942392 | doi =  }}
*{{cite journal | author=Travis A, Hagman J, Hwang L, Grosschedl R |title=Purification of early-B-cell factor and characterization of its DNA-binding specificity. |journal=Mol. Cell. Biol. |volume=13 |issue= 6 |pages= 3392-400 |year= 1993 |pmid= 8497258 |doi=  }}
* {{cite journal | vauthors = Gisler R, Sigvardsson M | title = The human V-preB promoter is a target for coordinated activation by early B cell factor and E47 | journal = J. Immunol. | volume = 168 | issue = 10 | pages = 5130–8 | year = 2002 | pmid = 11994467 | doi = 10.4049/jimmunol.168.10.5130 }}
*{{cite journal | author=Tsai RY, Reed RR |title=Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. |journal=J. Neurosci. |volume=17 |issue= 11 |pages= 4159-69 |year= 1997 |pmid= 9151733 |doi=  }}
* {{cite journal | vauthors = Smith EM, Gisler R, Sigvardsson M | title = Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression | journal = J. Immunol. | volume = 169 | issue = 1 | pages = 261–70 | year = 2002 | pmid = 12077253 | doi = 10.4049/jimmunol.169.1.261 }}
*{{cite journal | author=Gisler R, Jacobsen SE, Sigvardsson M |title=Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse. |journal=Blood |volume=96 |issue= 4 |pages= 1457-64 |year= 2000 |pmid= 10942392 |doi=  }}
* {{cite journal | vauthors = Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T | title = Inhibition of p300/CBP by early B-cell factor | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3837–46 | year = 2003 | pmid = 12748286 | pmc = 155219 | doi = 10.1128/MCB.23.11.3837-3846.2003 }}
*{{cite journal | author=Gisler R, Sigvardsson M |title=The human V-preB promoter is a target for coordinated activation by early B cell factor and E47. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5130-8 |year= 2002 |pmid= 11994467 |doi= }}
* {{cite journal | vauthors = Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C | title = CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1777–86 | year = 2004 | pmid = 14594818 | doi = 10.1074/jbc.M305418200 }}
*{{cite journal | author=Smith EM, Gisler R, Sigvardsson M |title=Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 261-70 |year= 2002 |pmid= 12077253 |doi= }}
* {{cite journal | vauthors = Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S | title = Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells | journal = Blood | volume = 103 | issue = 6 | pages = 2062–70 | year = 2004 | pmid = 14630787 | doi = 10.1182/blood-2003-07-2388 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M | title = Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development | journal = Blood | volume = 106 | issue = 6 | pages = 1995–2001 | year = 2005 | pmid = 15920012 | doi = 10.1182/blood-2004-12-4744 }}
*{{cite journal | author=Zhao F, McCarrick-Walmsley R, Akerblad P, ''et al.'' |title=Inhibition of p300/CBP by early B-cell factor. |journal=Mol. Cell. Biol. |volume=23 |issue= 11 |pages= 3837-46 |year= 2003 |pmid= 12748286 |doi= }}
* {{cite journal | vauthors = Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M | title = Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics | journal = Physiol. Genomics | volume = 23 | issue = 2 | pages = 206–16 | year = 2005 | pmid = 16106032 | doi = 10.1152/physiolgenomics.00015.2005 }}
*{{cite journal | author=Merluzzi S, Moretti M, Altamura S, ''et al.'' |title=CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1777-86 |year= 2004 |pmid= 14594818 |doi= 10.1074/jbc.M305418200 }}
* {{cite journal | vauthors = Martínez A, Mas A, de las Heras V, Arroyo R, Fernández-Arquero M, de la Concha EG, Urcelay E | title = Early B-cell Factor gene association with multiple sclerosis in the Spanish population | journal = BMC Neurol | volume = 5 | pages = 19 | year = 2005 | pmid = 16255771 | pmc = 1291372 | doi = 10.1186/1471-2377-5-19 }}
*{{cite journal | author=Bond HM, Mesuraca M, Carbone E, ''et al.'' |title=Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. |journal=Blood |volume=103 |issue= 6 |pages= 2062-70 |year= 2004 |pmid= 14630787 |doi= 10.1182/blood-2003-07-2388 }}
* {{cite journal | vauthors = Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R | title = Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5 | journal = Mol. Cell. Biol. | volume = 27 | issue = 2 | pages = 579–94 | year = 2007 | pmid = 17101802 | pmc = 1800812 | doi = 10.1128/MCB.01192-06 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Smith EM, Akerblad P, Kadesch T, ''et al.'' |title=Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. |journal=Blood |volume=106 |issue= 6 |pages= 1995-2001 |year= 2005 |pmid= 15920012 |doi= 10.1182/blood-2004-12-4744 }}
*{{cite journal | author=Akerblad P, Månsson R, Lagergren A, ''et al.'' |title=Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics. |journal=Physiol. Genomics |volume=23 |issue= 2 |pages= 206-16 |year= 2006 |pmid= 16106032 |doi= 10.1152/physiolgenomics.00015.2005 }}
*{{cite journal | author=Martínez A, Mas A, de las Heras V, ''et al.'' |title=Early B-cell Factor gene association with multiple sclerosis in the Spanish population. |journal=BMC neurology |volume=5 |issue=  |pages= 19 |year= 2006 |pmid= 16255771 |doi= 10.1186/1471-2377-5-19 }}
*{{cite journal | author=Roessler S, Györy I, Imhof S, ''et al.'' |title=Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. |journal=Mol. Cell. Biol. |volume=27 |issue= 2 |pages= 579-94 |year= 2007 |pmid= 17101802 |doi= 10.1128/MCB.01192-06 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{FactorBook|EBF1}}
 
 
{{gene-5-stub}}

Latest revision as of 15:10, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.[1][2][3]

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.[4][5] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.[6]

Interactions

EBF1 has been shown to interact with ZNF423[7] and CREB binding protein.[8]

References

  1. ↑ "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
  2. ↑ Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110.
  3. ↑ "Entrez Gene: EBF1 early B-cell factor 1".
  4. ↑ Treiber, Thomas; Mandel, Elizabeth M.; Pott, Sebastian; Györy, Ildiko; Firner, Sonja; Liu, Edison T.; Grosschedl, Rudolf. "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013.
  5. ↑ Hagman, James; Ramírez, Julita; Lukin, Kara (2012-01-01). "B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1". Current Topics in Microbiology and Immunology. 356: 17–38. doi:10.1007/82_2011_139. ISSN 0070-217X. PMC 3925327. PMID 21735360.
  6. ↑ Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004.
  7. ↑ Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.
  8. ↑ Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor" (PDF). Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=EBF1&oldid=1532801"