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{{DiseaseDisorder infobox |
__NOTOC__
  Name        = Dysplastic nevus |
{{Dysplastic nevus}}
  ICD10      = D48.5 |
{{CMG}} {{AE}}{{Faizan}}
  ICD9        = {{ICD9|238.2}} |
  ICDO        = 8727/0 |
}}
{{SI}}
{{CMG}}


{{SK}} atypical mole, Clark Nevus, Clark's Nevus


==[[Dysplastic nevus overview|Overview]]==


A '''dysplastic nevus''', (or ''naevus''; pl. ''nevi'' or ''naevi'') is an atypical [[mole (skin marking)|mole]]; a mole whose appearance is different from that of common moles.  Dysplastic nevi are generally larger than ordinary moles and have irregular and indistinct borders. Their color frequently is not uniform and ranges from pink to dark brown; they usually are flat, but parts may be raised above the skin surface.  Dysplastic nevus can be found anywhere, but are most common on the trunk in men, and on the calves in women.
==[[Dysplastic nevus historical perspective|Historical Perspective]]==


== Cancer ==
==[[Dysplastic nevus classification|Classification]]==
According to the [http://www.nci.nih.gov/ National Cancer Institute], doctors believe that dysplastic nevi are more likely than ordinary moles to develop into a type of [[skin cancer]] called [[melanoma]]. Because of this, moles should be checked regularly by a doctor or nurse specialist, especially if they look unusual; grow larger; or change in color, or outline; or if ''any'' changes occur.


== Biopsy ==
When an atypical mole has been identified, a [[biopsy]] takes place in order to best diagnose it.  Local anesthetic is used to numb the area, then the mole is biopsied.  The biopsy material is then sent to a [[laboratory]] to be evaluated by a [[Pathologist]].


==Atypical Mole Syndrome==
==[[Dysplastic nevus pathophysiology|Pathophysiology]]==
Atypical Mole Syndrome is a hereditary condition which causes the person to have a large quantity of moles (often 100 or more) with some dysplastic nevi.  This often leads to a higher [[risk]] of [[melanoma]], a serious [[skin cancer]].<ref>Burkhart, C.G MPH, MD. Dysplastic nevus declassified; even the NIH recommends elimination of confusing terminology. SKINmed: Dermatology for the Clinician 2(1):12-13, 2003.</ref>
A slight majority of melanomas do ''not'' form in an existing mole, but rather create a new [[growth]] on the skin. Nevertheless, those with more dysplastic nevi are at a higher risk of this type of melanoma occurrence.<ref>D.J. Pope, T. Sorahan, J.R. Marsden, P.M. Ball, R.P. Grimley and I.M. Peck. Benign pigmented nevi in children. Arch of Dermatology 2006;142:1599-1604</ref><ref>D.E. Goldgar, L.A. Cannon-Albright, L.J. Meyer, M.W. Pipekorn, J.J. Zone, M.H. Skolnick. Inheritance of Nevus Number and Size in Melanoma and Dysplastic Nevus Syndrome Kindreds. Journal of the National Cancer Institute 1991 83(23):1726-1733</ref> Such persons need to be checked regularly for any changes in their moles and to note any new ones.


== References ==
==[[Dysplastic nevus causes|Causes]]==
<references/>
 
==[[Dysplastic nevus differential diagnosis|Differentiating Dysplastic Nevus from other Diseases]]==
 
==[[Dysplastic nevus epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Dysplastic nevus risk factors|Risk Factors]]==
 
==[[Dysplastic nevus screening|Screening]]==
 
==[[Dysplastic nevus natural history|Natural History, Complications and Prognosis]]==
 
==[[Dysplastic nevus diagnosis|Diagnosis]]==
[[Dysplastic nevus history and symptoms|History and Symptoms]] | [[Dysplastic nevus physical examination|Physical Examination]] | [[Dysplastic nevus laboratory tests|Laboratory Findings]] | [[Dysplastic nevus other imaging findings|Other Imaging Findings]] | [[Dysplastic nevus other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Dysplastic nevus medical therapy|Medical Therapy]] | [[Dysplastic nevus surgery|Surgery]] | [[Dysplastic nevus primary prevention|Primary Prevention]] | [[Dysplastic nevus secondary prevention|Secondary Prevention]] | [[Dysplastic nevus cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Dysplastic nevus future or investigational therapies|Future or Investigational Therapies]]
==Case Studies==
:[[Dysplastic nevus case study one|Case #1]]


==External links==
==External links==
*[http://www.nci.nih.gov/cancertopics/wyntk/moles-and-dysplastic-nevi/ National Cancer Institute: What You Need To Know About Moles and Dysplastic Nevi]
*[http://www.nci.nih.gov/cancertopics/wyntk/moles-and-dysplastic-nevi/ National Cancer Institute: What You Need To Know About Moles and Dysplastic Nevi]


==See also==
*[[Nevus]]


{{Epithelial neoplasms}}
{{Epithelial neoplasms}}
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Latest revision as of 21:49, 25 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Synonyms and keywords: atypical mole, Clark Nevus, Clark's Nevus

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Dysplastic Nevus from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Other Imaging Findings | Other Diagnostic Studies

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Case #1

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