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<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #a3b0bf; border-bottom: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project|Mission Statement]]&nbsp;&nbsp;&nbsp;</div>
<div style="float:left; padding: .5ex 0; font-weight:bold; background-color:#dfe0e1; border:2px solid #a3b0bf; border-bottom: 0; font-size:90%">&nbsp;&nbsp;&nbsp;[[Drug project|Mission Statement]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #CEDFF2; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project tutorial|Tutorial]]&nbsp;&nbsp;&nbsp;</div>
<div style="float:left; padding: .5ex 0; font-weight:bold; background-color:#cedff2; border:2px solid #999; border-bottom: 0; border-left: 0; font-size:90%">&nbsp;&nbsp;&nbsp;[[Drug project tutorial|Tutorial]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project checklist|Editor's Checklist]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project list of medications|List of Medications]]&nbsp;&nbsp;&nbsp;</div>
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<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project high-priority medications|High-Priority Medications]]&nbsp;&nbsp;&nbsp;</div>
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==WikiDoc Drug Project — Tutorial==
==WikiDoc Drug Project — Tutorial==


<BIG><BIG>'''''1.&nbsp;&nbsp;Read before you proceed'''''</BIG></BIG>


===Step 0. Formatting Basics===
----
 
====0.1 Pasting as Plain Text====
 
:&nbsp;&nbsp;'''0.1.1'''&nbsp;&nbsp; Pasting as plain text must be done by '''Ctrl+Shift+V''' in Windows OS (or '''Cmd+Shift+Opt+V''' in Mac OS).
 
:&nbsp;&nbsp;'''0.1.2'''&nbsp;&nbsp; '''DO NOT USE CTRL+V (OR CMD+V in Mac OS) TO PASTE.'''
 
====0.2 Removing Extra Line Spaces====
 
:&nbsp;&nbsp;'''0.2.1'''&nbsp;&nbsp; Phantom line spaces generated during copy-pasting commonly appear between paragraphs and at the top. Remove extra line spaces before moving onto the next page.
 
====0.3 Inserting Images for Tables, Graphs, and Packages====
 
:&nbsp;&nbsp;'''0.3.1'''&nbsp;&nbsp; The width of inserted images should be 600px unless otherwise indicated.
 
:&nbsp;&nbsp;'''0.3.2'''&nbsp;&nbsp; Use the following wikicode:
<table style="border: 1px solid black"><tr><td>
<pre>
{|
| [[File:NAMEOFTHEIMAGE01.png|thumb|600px]]
|}
</pre>
</td></tr></table>
 
 
===Step 1. Selecting Appropriate FDA Package Inserts===
 
====1.1 Generic Names, Trade Names, and Formulations====
 
:&nbsp;&nbsp;'''1.1.1'''&nbsp;&nbsp; Check the generic name, trade names, and formulations of the drug from both '''DailyMed''' and '''Drugs@FDA'''.
 
:&nbsp;&nbsp;'''1.1.2'''&nbsp;&nbsp; Confirm the presence of '''Original Packager''' label of each available formulation (solution/tablet/spray) from DailyMed.
 
:&nbsp;&nbsp;'''1.1.3'''&nbsp;&nbsp; Select the '''earliest available''' '''Original Packager''' label.  Avoid using '''Repackager''' labels.
 
:&nbsp;&nbsp;'''1.1.4'''&nbsp;&nbsp; Take Clopidogrel as an example:
 
:::&nbsp;&nbsp; '''Clopidogrel''' is the generic name.
 
:::&nbsp;&nbsp; '''Plavix''' is the trade name.
 
:::&nbsp;&nbsp; The earliest available Original Packager label is '''[http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01b14603-8f29-4fa3-8d7e-9d523f802e0b this.]'''
 
:::&nbsp;&nbsp; Redirect '''Plavix''' to the '''Clopidogrel''' main page.
 
====1.2 When More Than One Formuation Exists====
 
:&nbsp;&nbsp;'''1.2.1'''&nbsp;&nbsp; Confirm the presence of '''Patient Information''' pages for different formulations on WikiDoc.
 
:&nbsp;&nbsp;'''1.2.2'''&nbsp;&nbsp; Place '''Patient Information''' links for different formulations between <nowiki>{{CMG}}</nowiki> and <nowiki>{{SB}}</nowiki>.


:&nbsp;&nbsp;'''1.2.3'''&nbsp;&nbsp; Refer to [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] as an example of a drug with multiple formulations.
'''''1.1&nbsp;&nbsp;Resources'''''


----


===Step 2. Drug Template===
'''''1.1.1&nbsp;&nbsp;[http://dailymed.nlm.nih.gov/dailymed/about.cfm DailyMed]'''''


====2.1 Creating the Drug Template====
: 1.1.1.1&nbsp;&nbsp;DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.


:&nbsp;&nbsp;'''2.1.1'''&nbsp;&nbsp; Search '''Template:(generic name of the drug, capitalize the first letter)''' in the search field.  (eg, Template:Clopidogrel)
'''''1.1.2&nbsp;&nbsp;[http://www.accessdata.fda.gov/Scripts/cder/drugsatfda/index.cfm Drugs@FDA]'''''


:&nbsp;&nbsp;'''2.1.2'''&nbsp;&nbsp; Click on '''Create the page "Template:(generic name of the drug)" on this wiki!'''&nbsp;&nbsp; which leads to an empty page.
: 1.1.2.1&nbsp;&nbsp;Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.


:&nbsp;&nbsp;'''2.1.3'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_drug_template Example Drug Template]'''.
'''''1.1.3&nbsp;&nbsp;[http://pillbox.nlm.nih.gov/pillimage/search.php Pillbox]'''''


:&nbsp;&nbsp;'''2.1.4'''&nbsp;&nbsp; Copy the code from the template and paste it back to the new drug template.  Replace XXXXX in the template by the generic name, YYYYY by the title in DailyMed and ZZZZZ (in the code) by the brand name you are using. For example, in the [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] page XXXXX corresponds to '''Metoprolol''', YYYYY corresponds to '''Lopressor (metoprolol tartrate) tablet''' and ZZZZZ corresponds to '''Lopressor'''.
: 1.1.3.1&nbsp;&nbsp;Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.  


:&nbsp;&nbsp;'''2.1.5'''&nbsp;&nbsp; When more than brand name exist, both of the brand names should be included in the template.  Refer to [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] page for an example.
: 1.1.3.2&nbsp;&nbsp;Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.


:&nbsp;&nbsp;'''2.1.6'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG TEMPLATE.'''
: 1.1.3.3&nbsp;&nbsp;Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.  


====2.2 Quality Checking the Drug Template====
'''''1.1.4&nbsp;&nbsp;[http://druginfo.nlm.nih.gov/drugportal/ Drug Information Portal]'''''


:&nbsp;&nbsp;'''2.2.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
: 1.1.4.1&nbsp;&nbsp;Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).


:&nbsp;&nbsp;'''2.2.2'''&nbsp;&nbsp; Make sure that the Warning Black Box in the template is in red.
: 1.1.4.2&nbsp;&nbsp;For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)


:&nbsp;&nbsp;'''2.2.3'''&nbsp;&nbsp; Make sure that the list of microchapters is similar to that of the template.
'''''1.1.5 [http://www.nlm.nih.gov/medlineplus/druginformation.html MedlinePlus]'''''


:&nbsp;&nbsp;'''2.2.4'''&nbsp;&nbsp; In case of multiple formulations, the links to chapters should start with the '''Trade names''' rather than the generic name.
: 1.1.5.1&nbsp;&nbsp;MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.


:&nbsp;&nbsp;'''2.2.5'''&nbsp;&nbsp; Refer to [http://www.wikidoc.org/index.php/Template:Metoprolol Metoprolol] as an example of a drug with multiple formulations.
----


===Step 3. Drug Homepage===
'''''1.2&nbsp;&nbsp;Generic name, active ingredient, compound, combination, trade name, formulation, and label'''''


====3.1 Creating/Amending the Drug Homepage====
----


:&nbsp;&nbsp;'''3.1.1'''&nbsp;&nbsp; Search the generic name of the drug in the search field.  You have reached the drug homepage.  Make sure that only the first letter of the name of the page is capitalized.
'''''1.2.1&nbsp;&nbsp;What is the generic name?'''''


:&nbsp;&nbsp;'''3.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_drug_homepage Example Drug Homepage]'''.
: 1.2.1.1&nbsp;&nbsp;Search and confirm the generic name of the drug.


:&nbsp;&nbsp;'''3.1.3'''&nbsp;&nbsp; Copy the code from the example drug homepage and paste it back to the drug homepage.
: 1.2.1.2&nbsp;&nbsp;Use the generic name as the title of the landing page.


:&nbsp;&nbsp;'''3.1.4'''&nbsp;&nbsp; Replace XXXXX by the generic name, replace ZZZZZ by the trade name and replace YYYYY by the DailyMed name in the template you've created.  If more than one brand name is to be used, include their corresponding DailyMed name under the section '''FDA Package Insert''' and make sure to surround them by three equal signs.
'''''1.2.2&nbsp;&nbsp;What is the active ingredient? Is there more than one compound for the active ingredient?'''''


:&nbsp;&nbsp;'''3.1.5'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG HOMEPAGE.'''
: 1.2.2.1&nbsp;&nbsp;Search and confirm the compound(s) of the active ingredient.


:&nbsp;&nbsp;'''3.1.6'''&nbsp;&nbsp; Accommodate preexisting contents, if any, to the standard format.
: 1.2.2.2&nbsp;&nbsp;If there is more than one type of compound, place links (as &lt;h3&gt; headings) of each compound at the top of the landing page.


:&nbsp;&nbsp;'''3.1.7'''&nbsp;&nbsp; '''DO NOT REMOVE WORKS DONE BY PREVIOUS EDITORS.'''
'''''1.2.3&nbsp;&nbsp;Is the active ingredient provided as combinations with other active ingredients?'''''


:&nbsp;&nbsp;'''3.1.8'''&nbsp;&nbsp; Include all trade names in <nowiki>{{SB}}</nowiki> and make proper redirections.  Make sure to seperate the brand names by a comma followed by a space. Make sure to capitalize the first letter of each brand name.
: 1.2.3.1&nbsp;&nbsp;If the active ingredient is also provided as combinations with other active ingredients, place links (as &lt;h3&gt; headings) of each combination at the top of the landing page.


:&nbsp;&nbsp;'''3.1.9'''&nbsp;&nbsp; Place '''Patient Information''' link between <nowiki>{{CMG}}</nowiki> and <nowiki>{{SB}}</nowiki>.  Make sure that the sentences corresponding to <nowiki>{{CMG}}</nowiki>, patient information and <nowiki>{{SB}}</nowiki> are on different lines.
'''''1.2.4&nbsp;&nbsp;What is the trade name?'''''


:&nbsp;&nbsp;'''3.1.10'''&nbsp;&nbsp; Visit MedlinePlus, if necessary, to collect data for Patient Information. To create Patient Information page for the drug, use the template '''[http://www.wikidoc.org/index.php/Drug_(patient_information) Example Drug (patient information)]'''.
: 1.2.4.1&nbsp;&nbsp;Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.


====3.2 The Headings on the Drug Homepage====
: 1.2.4.2&nbsp;&nbsp;Search and confirm the trade names for each combination (if any).
:&nbsp;&nbsp;'''3.2.1'''&nbsp;&nbsp; The drug homepage should contain the following titles: Overview, Category, FDA Package Insert, Taking Alcohol with XXXXX and References.


:&nbsp;&nbsp;'''3.2.2'''&nbsp;&nbsp; In the Overview section, provide a short description of the drug.  It should include the name of the generic drug in the first sentence.  
: 1.2.4.3&nbsp;&nbsp;List the trade names of each compound and/or combination in parentheses.


:&nbsp;&nbsp;'''3.2.3'''&nbsp;&nbsp; In the Category section, label the drug appropriately by adding appropriate categories.  The categories should match the existing category pages on Wikidoc (except for the category drugs <nowiki>[[Category:Drugs]]</nowiki>).  Make sure to separate the different categories by a comma followed by a space.  Make sure not to capitalize the words after coma.  The categories should be listed in alphabetical order.
: 1.2.4.4&nbsp;&nbsp;Sort the list of compunds and/or combinations in alphabetical order.


:&nbsp;&nbsp;'''3.2.4'''&nbsp;&nbsp; In the Taking Alcohol with XXXXX section:
'''''1.2.5&nbsp;&nbsp;What is the formulation?'''''
:::&nbsp;&nbsp;  Search the term '''Alcohol''' in the Package Insert on DailyMed.
:::&nbsp;&nbsp;  Place the information relating to combined alcohol use under the heading of '''Taking Alcohol with (Drug)'''.
:::&nbsp;&nbsp; If this information is lacking, insert the following statement: '''''Alcohol-(Drug) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.'''''


:&nbsp;&nbsp;'''3.2.5'''&nbsp;&nbsp; In the FDA Package insert section, make sure you include subtitles with the DailyMed names of the brand names of the drug.  The subtitles should be surrounded by three equal signs.
: 1.2.5.1&nbsp;&nbsp;Learn the concept of pharmaceutical formulations '''[[Pharmaceutical formulation|here]]'''.


:&nbsp;&nbsp;'''3.2.6'''&nbsp;&nbsp; In the Reference section, add the following: <nowiki>{{Reflist|2}} </nowiki> which allows the generation of references into two columns.
: 1.2.5.2&nbsp;&nbsp;Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.


====3.3 Quality Checking the Drug Homepage====
'''''1.2.6&nbsp;&nbsp;Which label should be used?'''''


:&nbsp;&nbsp;'''3.4.1'''&nbsp;&nbsp; Headings must be arranged in proper order (Overview, Category, FDA Package Insert, Taking Alcohol with (Drug), and References).
: 1.2.6.1&nbsp;&nbsp;Check the ''Marketing Start Date'' and the ''Revised date'' at the end of the label.


:&nbsp;&nbsp;'''3.4.2'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page.  Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in alphabetical order.
: 1.2.6.2&nbsp;&nbsp;Choose the label that is most recently updated as a reference.


:&nbsp;&nbsp;'''3.4.3'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
'''''1.2.7&nbsp;&nbsp;Example'''''


===Step 4. Brand Name Chapters===
: For the generic name '''Metoprolol''', there are two compounds of the active ingredient: '''metoprolol succinate''' and '''metoprolol tartrate'''.


====4.1 Creating the Brand Name Chapters====
: Available compounds, combinations, and trade names of '''Metoprolol''' are as follows:


:&nbsp;&nbsp;'''4.1.1'''&nbsp;&nbsp; Search the brand name of the drug in the search field. You have reached the brand name homepage. Make sure that only the first letter of the name of the page is capitalized.
: '''[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])'''


:&nbsp;&nbsp;'''4.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_brand_name_chapter Example Brand Name Chapter]'''.
: '''[[Metoprolol succinate/Hydrochlorothiazide]] ([[Dutoprol]])'''


:&nbsp;&nbsp;'''4.1.3'''&nbsp;&nbsp; Copy the code from the example drug homepage and paste it back to a brand name chapter.
: '''[[Metoprolol tartrate]] ([[Lopressor]])'''


:&nbsp;&nbsp;'''4.1.4'''&nbsp;&nbsp; Replace ZZZZZ in the code by the brand name of the drug.
: '''[[Metoprolol tartrate/Arginine]] ([[Hypertensolol]])'''


:&nbsp;&nbsp;'''4.1.5'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE BRAND NAME CHAPTER.'''
: '''[[Metoprolol tartrate/Hydrochlorothiazide]] ([[Lopressor HCT]])'''


:&nbsp;&nbsp;'''4.1.6'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page. Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in the alphabetical order.
----


<BIG><BIG>'''''2.&nbsp;&nbsp;Creating or editing a drug page'''''</BIG></BIG>


====4.2 Quality Checking the Drug Chapters====
----


:&nbsp;&nbsp;'''4.2.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
'''''2.1&nbsp;&nbsp;Landing page'''''


:&nbsp;&nbsp;'''4.2.2'''&nbsp;&nbsp; Make sure all uploaded pictures are appearing.
----


:&nbsp;&nbsp;'''4.2.3'''&nbsp;&nbsp; Remove extra line spaces and punctuation mistakes at the authorship field of each page.
'''''2.1.1&nbsp;&nbsp;Go to the [http://www.wikidoc.org/index.php/Special:Search search] page on WikiDoc.'''''


===Step 5. Brand Name Microchapters===
'''''2.1.2&nbsp;&nbsp;Use the generic name or active ingredient as search terms.'''''


====5.1 Creating the Brand Name Microchapters====
'''''2.1.3&nbsp;&nbsp;The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.'''''


:&nbsp;&nbsp;'''5.1.1'''&nbsp;&nbsp; Click on the name of one of the microchapters from the brand name home page. You have reached a microchapters. Make sure that only the first letter of the title of the page is capitalized.
: 2.1.3.1&nbsp;&nbsp;Gather all available formulations [http://search.usa.gov/search?affiliate=usagov&query= here].


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_brand_name_microchapter Example Brand Name Microchapter]'''.
: 2.1.3.2&nbsp;&nbsp;Create separate page for each available formulation.


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; Choose the appropriate information from the FDA package insert that fit the title of microchapter (eg: indications), copy it and paste it on the brand name microchapter. Make sure to remove irrelevant content such as numbering.
'''''2.1.4&nbsp;&nbsp;At the top of the landing page, place the links (as &lt;h3&gt; headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).'''''


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; If the content of each microchapters can be divided into several parts, choose an appropriate subheading for each part and surround it with 3 equal signs.  Make sure that the first letter of each word of the subtitle is capitalized.
: 2.1.4.1&nbsp;&nbsp;&lt;h3&gt; headings should begin and end with three "=" symbols.


:&nbsp;&nbsp;'''5.1.3'''&nbsp;&nbsp; If the copied content contains ''[see (Section) XX.X]'', replace it with hyperlink to the corresponding microchapter.
: 2.1.4.2&nbsp;&nbsp;Example: <nowiki>===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===</nowiki>


:&nbsp;&nbsp;'''5.1.4'''&nbsp;&nbsp; On the page '''Label and Packages''' create subheadings for each type of package label.  Under each subheading, retype the information provided on the Label and Packages of the FDA package insert and add the images in the same order of the FDA package insert.  Do not take a screenshot of texts but rather type them.  Refer to the [http://www.wikidoc.org/index.php/Lopressor_labels_and_packages Lopressor labels and package] page as an example.
'''''2.1.5&nbsp;&nbsp;Redirect the trade name pages to its generic compound page.'''''


:&nbsp;&nbsp;'''5.1.5'''&nbsp;&nbsp; Obtain the url of the drug label from DailyMed.
: 2.1.5.1&nbsp;&nbsp;Example 1: Redirect '''[[Lopressor]]''' to '''[[Metoprolol tartrate]]'''.


:&nbsp;&nbsp;'''5.1.6'''&nbsp;&nbsp; Create the reference wikicode and paste it back to the drug chapter.
: 2.1.5.2&nbsp;&nbsp;Example 2: Redirect both '''[[Toprol XL]]''' and '''[[Toprolxl XL]]''' to '''[[Metoprolol succinate]]'''.


:&nbsp;&nbsp;'''5.1.7'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG CHAPTER.'''
----


:&nbsp;&nbsp;'''5.1.8'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page. Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in the alphabetical order.
'''''2.2&nbsp;&nbsp;Using the Drug Project Form'''''


:&nbsp;&nbsp;'''5.1.9'''&nbsp;&nbsp; If the information for certain section is lacking, insert the following statement:
----


:::&nbsp;&nbsp; '''''FDA Package Insert for (Drug) contains no information regarding (Section).'''''
'''''2.2.1&nbsp;&nbsp;To create a drug page, Go to [[Form:DrugProjectForm]].'''''


====5.2 Black Box Warning====
'''''2.2.2&nbsp;&nbsp;Use the appropriate title for the drug page.'''''


:&nbsp;&nbsp;'''5.2.1'''&nbsp;&nbsp; Boxed warning information must be placed in the '''Brand name black box warning''' microchapter.
: 2.2.2.1&nbsp;&nbsp;If there is more than one compound for a generic name, use the generic name with compound as the title.


:&nbsp;&nbsp;'''5.2.2'''&nbsp;&nbsp; Use the following wikicode:
:: 2.2.2.1.1&nbsp;&nbsp;Example 1: Use '''Metoprolol succinate''' as the title.


<table style="border: 1px solid black"><tr><td>
:: 2.2.2.1.2&nbsp;&nbsp;Example 2: Use '''Metoprolol tartrate''' as the title.
<pre>
{| style="border: 3px solid #696969;"
| style="background: #000000; border: 0px; padding: 20px 20px; width: 800px;" |
<center>
<font color="#F8F8FF">'''WARNING'''</font>
</center>


<center>
: 2.2.2.2&nbsp;&nbsp;If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.
<font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font>
</center>


:: 2.2.2.2.1&nbsp;&nbsp;Example 1: '''Metoprolol succinate and Hydrochlorothiazide''' as the title.


<b><font color="#F8F8FF">
:: 2.2.2.2.2&nbsp;&nbsp;Example 2: '''Metoprolol tartrate and Arginine''' as the title.
* Item 1
* Item 2
* Item 2
</font></b>
|}
</pre>
</td></tr></table>


:&nbsp;&nbsp;'''4.2.3'''&nbsp;&nbsp; For instance, boxed warning alert for Toprol XL will appear as:
'''''2.2.3&nbsp;&nbsp;Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.'''''


{| style="border: 3px solid #696969;"
'''''2.2.4&nbsp;&nbsp;Follow the instructions under each tab to create contents.'''''
| style="background: #000000; border: 0px; padding: 20px 20px; width: 800px;" |
<center>
<font color="#F8F8FF">'''WARNING'''</font>
</center>


<center>
'''''2.2.5&nbsp;&nbsp;Pasted information <u>MUST BE PLAIN TEXT</u> rather than formatted text.'''''
<font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font>
</center>


: 2.2.5.1&nbsp;&nbsp;Pasting as plain text may be done by the keyboard shortcut '''Ctrl+Shift+V''' in Windows OS (or '''Cmd+Shift+Opt+V''' in Mac OS).


<b><font color="#F8F8FF">
: 2.2.5.2&nbsp;&nbsp;<u>DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE</u>.
Following abrupt cessation of therapy with beta-blocking agents, exacerbations of angina pectoris and myocardial infarction have occurred. Warn patients against interruption or discontinuation of therapy without the physician’s advice.
</font></b>
|}


====5.3 Indications====
'''''2.2.6&nbsp;&nbsp;Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.'''''
:&nbsp;&nbsp;'''5.3.1'''&nbsp;&nbsp;In the indications microchapter, make sure to include the following two subheadings surrounded by two equal signs: '''FDA Labeled Indications''' and '''Off Label Indications'''.


:&nbsp;&nbsp;'''5.3.2'''&nbsp;&nbsp; Under '''FDA Labeled Indications''', copy the content from the FDA label.  Make sure that the content is categorized by the different types
'''''2.2.7&nbsp;&nbsp;Proofread and hyperlink after completing all sections.'''''


:&nbsp;&nbsp;'''5.3.3'''&nbsp;&nbsp; Under '''Off Label Indications''', include the following disclaimer sentence: '''''WikiDoc Drug Project is a constellation of drug information for healthcare providers and patients vigorously vetted on the basis of FDA package insert, MedlinePlus, Practice Guidelines, Scientific Statements, and scholarly medical literature. The information provided is not a medical advice or treatment. WikiDoc does not promote any medication or off-label use of drugs.''''' The disclaimer sentence should be in bold and italic.
'''''2.2.8&nbsp;&nbsp;Add <nowiki>[[Category:Drug]]</nowiki> and other applicable categories in alphabetical order at the end.'''''


:&nbsp;&nbsp;'''5.3.4'''&nbsp;&nbsp; Under '''Off Label Indications''', include a list of indications not approved by the FDA in the following order whenever applicable:
----
:::&nbsp;&nbsp; <nowiki> ====Adult==== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Acute===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Chronic===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Prophylaxis===== </nowiki>
:::&nbsp;&nbsp; <nowiki> ====Pediatrics==== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Acute===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Chronic===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Prophylaxis===== </nowiki>


:&nbsp;&nbsp;'''5.3.5'''&nbsp;&nbsp; For each of the off label indication, include the dosage, the class and category/level of evidence and the reference.
'''''2.3&nbsp;&nbsp;Contraindicated Medications in Specific Conditions'''''


====5.4 Quality Checking the Brand Name Microchapters====
----


:&nbsp;&nbsp;'''5.4.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
'''''2.3.1&nbsp;&nbsp;Harvest contraindications from the FDA drug label.'''''


:&nbsp;&nbsp;'''5.4.2'''&nbsp;&nbsp; Make sure all uploaded pictures are appearing.
'''''2.3.2&nbsp;&nbsp;Go to the Medical Therapy chapter of each contraindication.'''''


:&nbsp;&nbsp;'''5.4.3'''&nbsp;&nbsp; Remove extra line spaces and punctuation mistakes at the authorship field of each page.
'''''2.3.3&nbsp;&nbsp;Place the following template before the ''References'' section.'''''
<div style="width: 500px;"><pre>
===Contraindicated Medications===
{{MedCondContrAbs
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}
</pre></div>


:&nbsp;&nbsp;'''5.4.4'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page. Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in the alphabetical order.
----


===Step 6. Completion===
'''''2.4&nbsp;&nbsp;Adding Medications to the Causes Chapter of Significant Adverse Reactions'''''


====5.1 Fix all the errors before announcing the completion.====
----


====5.2 Update the status in the progress spreadsheet.====
'''''2.4.1&nbsp;&nbsp;Harvest severe adverse reactions from the Warnings section of FDA drug label.'''''


====5.3 Submit the page for peer review.====
'''''2.4.2&nbsp;&nbsp;For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.'''''


'''''2.4.3&nbsp;&nbsp;Perform Chi-square calculations to determine the significance of adverse reactions.  Outsource if necessary.'''''


'''''2.4.4&nbsp;&nbsp;Add the medication to the Causes chapter of each significant adverse reaction.'''''


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Latest revision as of 16:47, 18 December 2017

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WikiDoc Drug Project — Tutorial

1.  Read before you proceed


1.1  Resources


1.1.1  DailyMed

1.1.1.1  DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.

1.1.2  Drugs@FDA

1.1.2.1  Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.

1.1.3  Pillbox

1.1.3.1  Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.
1.1.3.2  Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.
1.1.3.3  Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.

1.1.4  Drug Information Portal

1.1.4.1  Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).
1.1.4.2  For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)

1.1.5 MedlinePlus

1.1.5.1  MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.

1.2  Generic name, active ingredient, compound, combination, trade name, formulation, and label


1.2.1  What is the generic name?

1.2.1.1  Search and confirm the generic name of the drug.
1.2.1.2  Use the generic name as the title of the landing page.

1.2.2  What is the active ingredient? Is there more than one compound for the active ingredient?

1.2.2.1  Search and confirm the compound(s) of the active ingredient.
1.2.2.2  If there is more than one type of compound, place links (as <h3> headings) of each compound at the top of the landing page.

1.2.3  Is the active ingredient provided as combinations with other active ingredients?

1.2.3.1  If the active ingredient is also provided as combinations with other active ingredients, place links (as <h3> headings) of each combination at the top of the landing page.

1.2.4  What is the trade name?

1.2.4.1  Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.
1.2.4.2  Search and confirm the trade names for each combination (if any).
1.2.4.3  List the trade names of each compound and/or combination in parentheses.
1.2.4.4  Sort the list of compunds and/or combinations in alphabetical order.

1.2.5  What is the formulation?

1.2.5.1  Learn the concept of pharmaceutical formulations here.
1.2.5.2  Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.

1.2.6  Which label should be used?

1.2.6.1  Check the Marketing Start Date and the Revised date at the end of the label.
1.2.6.2  Choose the label that is most recently updated as a reference.

1.2.7  Example

For the generic name Metoprolol, there are two compounds of the active ingredient: metoprolol succinate and metoprolol tartrate.
Available compounds, combinations, and trade names of Metoprolol are as follows:
Metoprolol succinate (Toprol XL, Toprolxl XL)
Metoprolol succinate/Hydrochlorothiazide (Dutoprol)
Metoprolol tartrate (Lopressor)
Metoprolol tartrate/Arginine (Hypertensolol)
Metoprolol tartrate/Hydrochlorothiazide (Lopressor HCT)

2.  Creating or editing a drug page


2.1  Landing page


2.1.1  Go to the search page on WikiDoc.

2.1.2  Use the generic name or active ingredient as search terms.

2.1.3  The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.

2.1.3.1  Gather all available formulations here.
2.1.3.2  Create separate page for each available formulation.

2.1.4  At the top of the landing page, place the links (as <h3> headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).

2.1.4.1  <h3> headings should begin and end with three "=" symbols.
2.1.4.2  Example: ===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===

2.1.5  Redirect the trade name pages to its generic compound page.

2.1.5.1  Example 1: Redirect Lopressor to Metoprolol tartrate.
2.1.5.2  Example 2: Redirect both Toprol XL and Toprolxl XL to Metoprolol succinate.

2.2  Using the Drug Project Form


2.2.1  To create a drug page, Go to Form:DrugProjectForm.

2.2.2  Use the appropriate title for the drug page.

2.2.2.1  If there is more than one compound for a generic name, use the generic name with compound as the title.
2.2.2.1.1  Example 1: Use Metoprolol succinate as the title.
2.2.2.1.2  Example 2: Use Metoprolol tartrate as the title.
2.2.2.2  If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.
2.2.2.2.1  Example 1: Metoprolol succinate and Hydrochlorothiazide as the title.
2.2.2.2.2  Example 2: Metoprolol tartrate and Arginine as the title.

2.2.3  Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.

2.2.4  Follow the instructions under each tab to create contents.

2.2.5  Pasted information MUST BE PLAIN TEXT rather than formatted text.

2.2.5.1  Pasting as plain text may be done by the keyboard shortcut Ctrl+Shift+V in Windows OS (or Cmd+Shift+Opt+V in Mac OS).
2.2.5.2  DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE.

2.2.6  Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.

2.2.7  Proofread and hyperlink after completing all sections.

2.2.8  Add [[Category:Drug]] and other applicable categories in alphabetical order at the end.


2.3  Contraindicated Medications in Specific Conditions


2.3.1  Harvest contraindications from the FDA drug label.

2.3.2  Go to the Medical Therapy chapter of each contraindication.

2.3.3  Place the following template before the References section.

===Contraindicated Medications===
{{MedCondContrAbs
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}

2.4  Adding Medications to the Causes Chapter of Significant Adverse Reactions


2.4.1  Harvest severe adverse reactions from the Warnings section of FDA drug label.

2.4.2  For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.

2.4.3  Perform Chi-square calculations to determine the significance of adverse reactions. Outsource if necessary.

2.4.4  Add the medication to the Causes chapter of each significant adverse reaction.