Drug project tutorial

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WikiDoc Drug Project — Tutorial

1.  Read before you proceed


1.1  Resources


1.1.1  DailyMed

1.1.1.1  DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.

1.1.2  Drugs@FDA

1.1.2.1  Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.

1.1.3  Pillbox

1.1.3.1  Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.
1.1.3.2  Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.
1.1.3.3  Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.

1.1.4  Drug Information Portal

1.1.4.1  Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).
1.1.4.2  For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)

1.1.5 MedlinePlus

1.1.5.1  MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.

1.2  Generic name, active ingredient, compound, combination, trade name, formulation, and label


1.2.1  What is the generic name?

1.2.1.1  Search and confirm the generic name of the drug.
1.2.1.2  Use the generic name as the title of the landing page.

1.2.2  What is the active ingredient? Is there more than one compound for the active ingredient?

1.2.2.1  Search and confirm the compound(s) of the active ingredient.
1.2.2.2  If there is more than one type of compound, place links (as <h3> headings) of each compound at the top of the landing page.

1.2.3  Is the active ingredient provided as combinations with other active ingredients?

1.2.3.1  If the active ingredient is also provided as combinations with other active ingredients, place links (as <h3> headings) of each combination at the top of the landing page.

1.2.4  What is the trade name?

1.2.4.1  Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.
1.2.4.2  Search and confirm the trade names for each combination (if any).
1.2.4.3  List the trade names of each compound and/or combination in parentheses.
1.2.4.4  Sort the list of compunds and/or combinations in alphabetical order.

1.2.5  What is the formulation?

1.2.5.1  Learn the concept of pharmaceutical formulations here.
1.2.5.2  Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.

1.2.6  Which label should be used?

1.2.6.1  Check the Marketing Start Date and the Revised date at the end of the label.
1.2.6.2  Choose the label that is most recently updated as a reference.

1.2.7  Example

For the generic name Metoprolol, there are two compounds of the active ingredient: metoprolol succinate and metoprolol tartrate.
Available compounds, combinations, and trade names of Metoprolol are as follows:
Metoprolol succinate (Toprol XL, Toprolxl XL)
Metoprolol succinate/Hydrochlorothiazide (Dutoprol)
Metoprolol tartrate (Lopressor)
Metoprolol tartrate/Arginine (Hypertensolol)
Metoprolol tartrate/Hydrochlorothiazide (Lopressor HCT)

2.  Creating or editing a drug page


2.1  Landing page


2.1.1  Go to the search page on WikiDoc.

2.1.2  Use the generic name or active ingredient as search terms.

2.1.3  The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.

2.1.3.1  Gather all available formulations here.
2.1.3.2  Create separate page for each available formulation.

2.1.4  At the top of the landing page, place the links (as <h3> headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).

2.1.4.1  <h3> headings should begin and end with three "=" symbols.
2.1.4.2  Example: ===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===

2.1.5  Redirect the trade name pages to its generic compound page.

2.1.5.1  Example 1: Redirect Lopressor to Metoprolol tartrate.
2.1.5.2  Example 2: Redirect both Toprol XL and Toprolxl XL to Metoprolol succinate.

2.2  Using the Drug Project Form


2.2.1  To create a drug page, Go to Form:DrugProjectForm.

2.2.2  Use the appropriate title for the drug page.

2.2.2.1  If there is more than one compound for a generic name, use the generic name with compound as the title.
2.2.2.1.1  Example 1: Use Metoprolol succinate as the title.
2.2.2.1.2  Example 2: Use Metoprolol tartrate as the title.
2.2.2.2  If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.
2.2.2.2.1  Example 1: Metoprolol succinate and Hydrochlorothiazide as the title.
2.2.2.2.2  Example 2: Metoprolol tartrate and Arginine as the title.

2.2.3  Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.

2.2.4  Follow the instructions under each tab to create contents.

2.2.5  Pasted information MUST BE PLAIN TEXT rather than formatted text.

2.2.5.1  Pasting as plain text may be done by the keyboard shortcut Ctrl+Shift+V in Windows OS (or Cmd+Shift+Opt+V in Mac OS).
2.2.5.2  DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE.

2.2.6  Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.

2.2.7  Proofread and hyperlink after completing all sections.

2.2.8  Add [[Category:Drug]] and other applicable categories in alphabetical order at the end.


2.3  Contraindicated Medications in Specific Conditions


2.3.1  Harvest contraindications from the FDA drug label.

2.3.2  Go to the Medical Therapy chapter of each contraindication.

2.3.3  Place the following template before the References section.

===Contraindicated Medications===
{{MedCondContrAbs
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}

2.4  Adding Medications to the Causes Chapter of Significant Adverse Reactions


2.4.1  Harvest severe adverse reactions from the Warnings section of FDA drug label.

2.4.2  For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.

2.4.3  Perform Chi-square calculations to determine the significance of adverse reactions. Outsource if necessary.

2.4.4  Add the medication to the Causes chapter of each significant adverse reaction.


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