Drug project tutorial: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(28 intermediate revisions by 4 users not shown)
Line 1: Line 1:
__NOTOC__
<div style="width: 1px; height: 1px; background-color: #999999; position: fixed; top: 10px; left: 10px"></div><div style="-webkit-user-select: none;">
{{CMG}}
__NOEDITSECTION____NOTOC__
 
<div style="text-align: center;">
<div style="text-align:center;">
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #a3b0bf; border-bottom: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project|Mission Statement]]&nbsp;&nbsp;&nbsp;</div>
<div style="float:left; padding: .5ex 0; font-weight:bold; background-color:#dfe0e1; border:2px solid #a3b0bf; border-bottom: 0; font-size:90%">&nbsp;&nbsp;&nbsp;[[Drug project|Mission Statement]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #CEDFF2; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project tutorial|Tutorial]]&nbsp;&nbsp;&nbsp;</div>
<div style="float:left; padding: .5ex 0; font-weight:bold; background-color:#cedff2; border:2px solid #999; border-bottom: 0; border-left: 0; font-size:90%">&nbsp;&nbsp;&nbsp;[[Drug project tutorial|Tutorial]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project checklist|Editor's Checklist]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project list of medications|List of Medications]]&nbsp;&nbsp;&nbsp;</div>
</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project high-priority medications|High-Priority Medications]]&nbsp;&nbsp;&nbsp;</div>
</div>
</div>
 
<div style="clear:both; width: 95%; border: 3px solid #999; padding: 1em 1em; font-size: 120%;">
<div style="clear:both; width:100%; border:3px solid #999;">
<div style="padding:1ex; ">
 
<div style="float: left; width: 100%; padding-bottom: 1em;">
<div style="float: right; padding-right: 0%; font-size:135%">
 
==WikiDoc Drug Project — Tutorial==
==WikiDoc Drug Project — Tutorial==


<BIG><BIG>'''''1.&nbsp;&nbsp;Read before you proceed'''''</BIG></BIG>


===Step 0. Formatting Basics===
----
 
====0.1 Pasting as Plain Text====
 
:&nbsp;&nbsp;'''0.1.1'''&nbsp;&nbsp; Pasting as plain text must be done by '''Ctrl+Shift+V''' in Windows OS (or '''Cmd+Shift+Opt+V''' in Mac OS).
 
:&nbsp;&nbsp;'''0.1.2'''&nbsp;&nbsp; '''DO NOT USE CTRL+V (OR CMD+V in Mac OS) TO PASTE.'''
 
====0.2 Removing Extra Line Spaces====
 
:&nbsp;&nbsp;'''0.2.1'''&nbsp;&nbsp; Phantom line spaces generated during copy-pasting commonly appear between paragraphs and at the top. Remove extra line spaces before moving onto the next page.
 
====0.3 Inserting Images for Tables, Graphs, and Packages====
 
:&nbsp;&nbsp;'''0.3.1'''&nbsp;&nbsp; The width of inserted images should be 600px unless otherwise indicated.
 
:&nbsp;&nbsp;'''0.3.2'''&nbsp;&nbsp; Use the following wikicode:
<table style="border: 1px solid black"><tr><td>
<pre>
{|
| [[File:NAMEOFTHEIMAGE01.png|thumb|600px]]
|}
</pre>
</td></tr></table>
 
 
===Step 1. Selecting Appropriate FDA Package Inserts===


====1.1 Generic Names, Trade Names, and Formulations====
'''''1.1&nbsp;&nbsp;Resources'''''


:&nbsp;&nbsp;'''1.1.1'''&nbsp;&nbsp; Check the generic name, trade names, and formulations of the drug from both '''DailyMed''' and '''Drugs@FDA'''.
----


:&nbsp;&nbsp;'''1.1.2'''&nbsp;&nbsp; Confirm the presence of '''Original Packager''' label of each available formulation (solution/tablet/spray) from DailyMed.
'''''1.1.1&nbsp;&nbsp;[http://dailymed.nlm.nih.gov/dailymed/about.cfm DailyMed]'''''


:&nbsp;&nbsp;'''1.1.3'''&nbsp;&nbsp; Select the '''earliest available''' '''Original Packager''' label.  Avoid using '''Repackager''' labels.
: 1.1.1.1&nbsp;&nbsp;DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.


:&nbsp;&nbsp;'''1.1.4'''&nbsp;&nbsp; Take Clopidogrel as an example:
'''''1.1.2&nbsp;&nbsp;[http://www.accessdata.fda.gov/Scripts/cder/drugsatfda/index.cfm Drugs@FDA]'''''


:::&nbsp;&nbsp; '''Clopidogrel''' is the generic name.
: 1.1.2.1&nbsp;&nbsp;Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.


:::&nbsp;&nbsp; '''Plavix''' is the trade name.
'''''1.1.3&nbsp;&nbsp;[http://pillbox.nlm.nih.gov/pillimage/search.php Pillbox]'''''


:::&nbsp;&nbsp; The earliest available Original Packager label is '''[http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01b14603-8f29-4fa3-8d7e-9d523f802e0b this.]'''
: 1.1.3.1&nbsp;&nbsp;Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.  


:::&nbsp;&nbsp; Redirect '''Plavix''' to the '''Clopidogrel''' main page.
: 1.1.3.2&nbsp;&nbsp;Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.


====1.2 When More Than One Formuation Exists====
: 1.1.3.3&nbsp;&nbsp;Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.


:&nbsp;&nbsp;'''1.2.1'''&nbsp;&nbsp; Confirm the presence of '''Patient Information''' pages for different formulations on WikiDoc.
'''''1.1.4&nbsp;&nbsp;[http://druginfo.nlm.nih.gov/drugportal/ Drug Information Portal]'''''


:&nbsp;&nbsp;'''1.2.2'''&nbsp;&nbsp; Place '''Patient Information''' links for different formulations between <nowiki>{{CMG}}</nowiki> and <nowiki>{{SB}}</nowiki>.
: 1.1.4.1&nbsp;&nbsp;Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).


:&nbsp;&nbsp;'''1.2.3'''&nbsp;&nbsp; Refer to [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] as an example of a drug with multiple formulations.
: 1.1.4.2&nbsp;&nbsp;For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)


'''''1.1.5 [http://www.nlm.nih.gov/medlineplus/druginformation.html MedlinePlus]'''''


===Step 2. Drug Template===
: 1.1.5.1&nbsp;&nbsp;MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.


====2.1 Creating the Drug Template====
----


:&nbsp;&nbsp;'''2.1.1'''&nbsp;&nbsp; Search '''Template:(generic name of the drug, capitalize the first letter)''' in the search field.  (eg, Template:Clopidogrel)
'''''1.2&nbsp;&nbsp;Generic name, active ingredient, compound, combination, trade name, formulation, and label'''''


:&nbsp;&nbsp;'''2.1.2'''&nbsp;&nbsp; Click on '''Create the page "Template:(generic name of the drug)" on this wiki!'''&nbsp;&nbsp; which leads to an empty page.
----


:&nbsp;&nbsp;'''2.1.3'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_drug_template Example Drug Template]'''.
'''''1.2.1&nbsp;&nbsp;What is the generic name?'''''


:&nbsp;&nbsp;'''2.1.4'''&nbsp;&nbsp; Copy the code from the template and paste it back to the new drug template.  Replace XXXXX in the template by the generic name, YYYYY by the title in DailyMed and ZZZZZ (in the code) by the brand name you are using.  For example, in the [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] page XXXXX corresponds to '''Metoprolol''', YYYYY corresponds to '''Lopressor (metoprolol tartrate) tablet''' and ZZZZZ corresponds to '''Lopressor'''.
: 1.2.1.1&nbsp;&nbsp;Search and confirm the generic name of the drug.


:&nbsp;&nbsp;'''2.1.5'''&nbsp;&nbsp; When more than brand name exist, both of the brand names should be included in the template.  Refer to [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] page for an example.
: 1.2.1.2&nbsp;&nbsp;Use the generic name as the title of the landing page.


:&nbsp;&nbsp;'''2.1.6'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG TEMPLATE.'''
'''''1.2.2&nbsp;&nbsp;What is the active ingredient? Is there more than one compound for the active ingredient?'''''


====2.2 Quality Checking the Drug Template====
: 1.2.2.1&nbsp;&nbsp;Search and confirm the compound(s) of the active ingredient.


:&nbsp;&nbsp;'''2.2.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
: 1.2.2.2&nbsp;&nbsp;If there is more than one type of compound, place links (as &lt;h3&gt; headings) of each compound at the top of the landing page.


:&nbsp;&nbsp;'''2.2.2'''&nbsp;&nbsp; Make sure that the Warning Black Box in the template is in red.
'''''1.2.3&nbsp;&nbsp;Is the active ingredient provided as combinations with other active ingredients?'''''


:&nbsp;&nbsp;'''2.2.3'''&nbsp;&nbsp; Make sure that the list of microchapters is similar to that of the template.
: 1.2.3.1&nbsp;&nbsp;If the active ingredient is also provided as combinations with other active ingredients, place links (as &lt;h3&gt; headings) of each combination at the top of the landing page.


:&nbsp;&nbsp;'''2.2.4'''&nbsp;&nbsp; In case of multiple formulations, the links to chapters should start with the '''Trade names''' rather than the generic name.
'''''1.2.4&nbsp;&nbsp;What is the trade name?'''''


:&nbsp;&nbsp;'''2.2.5'''&nbsp;&nbsp; Refer to [http://www.wikidoc.org/index.php/Template:Metoprolol Metoprolol] as an example of a drug with multiple formulations.
: 1.2.4.1&nbsp;&nbsp;Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.


===Step 3. Drug Homepage===
: 1.2.4.2&nbsp;&nbsp;Search and confirm the trade names for each combination (if any).


====3.1 Creating/Amending the Drug Homepage====
: 1.2.4.3&nbsp;&nbsp;List the trade names of each compound and/or combination in parentheses.


:&nbsp;&nbsp;'''3.1.1'''&nbsp;&nbsp; Search the generic name of the drug in the search field.  You have reached the drug homepage.  Make sure that only the first letter of the name of the page is capitalized.
: 1.2.4.4&nbsp;&nbsp;Sort the list of compunds and/or combinations in alphabetical order.


:&nbsp;&nbsp;'''3.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_drug_homepage Example Drug Homepage]'''.
'''''1.2.5&nbsp;&nbsp;What is the formulation?'''''


:&nbsp;&nbsp;'''3.1.3'''&nbsp;&nbsp; Copy the code from the example drug homepage and paste it back to the drug homepage.
: 1.2.5.1&nbsp;&nbsp;Learn the concept of pharmaceutical formulations '''[[Pharmaceutical formulation|here]]'''.


:&nbsp;&nbsp;'''3.1.4'''&nbsp;&nbsp; Replace XXXXX by the generic name, replace ZZZZZ by the trade name and replace YYYYY by the DailyMed name in the template you've created. If more than one brand name is to be used, include their corresponding DailyMed name under the section '''FDA Package Insert''' and make sure to surround them by three equal signs.
: 1.2.5.2&nbsp;&nbsp;Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.


:&nbsp;&nbsp;'''3.1.5'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG HOMEPAGE.'''
'''''1.2.6&nbsp;&nbsp;Which label should be used?'''''


:&nbsp;&nbsp;'''3.1.6'''&nbsp;&nbsp; Accommodate preexisting contents, if any, to the standard format.
: 1.2.6.1&nbsp;&nbsp;Check the ''Marketing Start Date'' and the ''Revised date'' at the end of the label.


:&nbsp;&nbsp;'''3.1.7'''&nbsp;&nbsp; '''DO NOT REMOVE WORKS DONE BY PREVIOUS EDITORS.'''
: 1.2.6.2&nbsp;&nbsp;Choose the label that is most recently updated as a reference.


:&nbsp;&nbsp;'''3.1.8'''&nbsp;&nbsp; Include all trade names in <nowiki>{{SB}}</nowiki> and make proper redirections.  Make sure to seperate the brand names by a comma followed by a space. Make sure to capitalize the first letter of each brand name.
'''''1.2.7&nbsp;&nbsp;Example'''''


:&nbsp;&nbsp;'''3.1.9'''&nbsp;&nbsp; Place '''Patient Information''' link between <nowiki>{{CMG}}</nowiki> and <nowiki>{{SB}}</nowiki>.  Make sure that the sentences corresponding to <nowiki>{{CMG}}</nowiki>, patient information and <nowiki>{{SB}}</nowiki> are on different lines.
: For the generic name '''Metoprolol''', there are two compounds of the active ingredient: '''metoprolol succinate''' and '''metoprolol tartrate'''.


:&nbsp;&nbsp;'''3.1.10'''&nbsp;&nbsp; Visit MedlinePlus, if necessary, to collect data for Patient Information. To create Patient Information page for the drug, use the template '''[http://www.wikidoc.org/index.php/Drug_(patient_information) Example Drug (patient information)]'''.
: Available compounds, combinations, and trade names of '''Metoprolol''' are as follows:


====3.2 The Headings on the Drug Homepage====
: '''[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])'''
:&nbsp;&nbsp;'''3.2.1'''&nbsp;&nbsp; The drug homepage should contain the following titles: Overview, Category, FDA Package Insert, Taking Alcohol with XXXXX and References.


:&nbsp;&nbsp;'''3.2.2'''&nbsp;&nbsp; In the Overview section, provide a short description of the drug.  It should include the name of the generic drug in the first sentence.
: '''[[Metoprolol succinate/Hydrochlorothiazide]] ([[Dutoprol]])'''


:&nbsp;&nbsp;'''3.2.3'''&nbsp;&nbsp; In the Category section, label the drug appropriately by adding appropriate categories.  The categories should match the existing category pages on Wikidoc (except for the category drugs <nowiki>[[Category:Drugs]]</nowiki>).  Make sure to separate the different categories by a comma followed by a space.  Make sure not to capitalize the words after coma.  The categories should be listed in alphabetical order.
: '''[[Metoprolol tartrate]] ([[Lopressor]])'''


:&nbsp;&nbsp;'''3.2.4'''&nbsp;&nbsp; In the Taking Alcohol with XXXXX section:
: '''[[Metoprolol tartrate/Arginine]] ([[Hypertensolol]])'''
:::&nbsp;&nbsp;  Search the term '''Alcohol''' in the Package Insert on DailyMed.
:::&nbsp;&nbsp;  Place the information relating to combined alcohol use under the heading of '''Taking Alcohol with (Drug)'''.
:::&nbsp;&nbsp;  If this information is lacking, insert the following statement: '''''Alcohol-(Drug) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.'''''


:&nbsp;&nbsp;'''3.2.5'''&nbsp;&nbsp; In the FDA Package insert section, make sure you include subtitles with the DailyMed names of the brand names of the drug.  The subtitles should be surrounded by three equal signs.
: '''[[Metoprolol tartrate/Hydrochlorothiazide]] ([[Lopressor HCT]])'''


:&nbsp;&nbsp;'''3.2.6'''&nbsp;&nbsp; In the Reference section, add the following: <nowiki>{{Reflist|2}} </nowiki> which allows the generation of references into two columns.
----


====3.3 Quality Checking the Drug Homepage====
<BIG><BIG>'''''2.&nbsp;&nbsp;Creating or editing a drug page'''''</BIG></BIG>


:&nbsp;&nbsp;'''3.4.1'''&nbsp;&nbsp; Headings must be arranged in proper order (Overview, Category, FDA Package Insert, Taking Alcohol with (Drug), and References).
----


:&nbsp;&nbsp;'''3.4.2'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page.  Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in alphabetical order.
'''''2.1&nbsp;&nbsp;Landing page'''''


:&nbsp;&nbsp;'''3.4.3'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
----


===Step 4. Brand Name Chapters===
'''''2.1.1&nbsp;&nbsp;Go to the [http://www.wikidoc.org/index.php/Special:Search search] page on WikiDoc.'''''


====4.1 Creating the Brand Name Chapters====
'''''2.1.2&nbsp;&nbsp;Use the generic name or active ingredient as search terms.'''''


:&nbsp;&nbsp;'''4.1.1'''&nbsp;&nbsp; Search the brand name of the drug in the search field. You have reached the brand name homepage. Make sure that only the first letter of the name of the page is capitalized.
'''''2.1.3&nbsp;&nbsp;The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.'''''


:&nbsp;&nbsp;'''4.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_brand_name_chapter Example Brand Name Chapter]'''.
: 2.1.3.1&nbsp;&nbsp;Gather all available formulations [http://search.usa.gov/search?affiliate=usagov&query= here].


:&nbsp;&nbsp;'''4.1.3'''&nbsp;&nbsp; Copy the code from the example drug homepage and paste it back to a brand name chapter.
: 2.1.3.2&nbsp;&nbsp;Create separate page for each available formulation.


:&nbsp;&nbsp;'''4.1.4'''&nbsp;&nbsp; Replace ZZZZZ in the code by the brand name of the drug.
'''''2.1.4&nbsp;&nbsp;At the top of the landing page, place the links (as &lt;h3&gt; headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).'''''


:&nbsp;&nbsp;'''4.1.5'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE BRAND NAME CHAPTER.'''
: 2.1.4.1&nbsp;&nbsp;&lt;h3&gt; headings should begin and end with three "=" symbols.


:&nbsp;&nbsp;'''4.1.6'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page. Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in the alphabetical order.
: 2.1.4.2&nbsp;&nbsp;Example: <nowiki>===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===</nowiki>


'''''2.1.5&nbsp;&nbsp;Redirect the trade name pages to its generic compound page.'''''


====4.2 Quality Checking the Drug Chapters====
: 2.1.5.1&nbsp;&nbsp;Example 1: Redirect '''[[Lopressor]]''' to '''[[Metoprolol tartrate]]'''.


:&nbsp;&nbsp;'''4.2.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
: 2.1.5.2&nbsp;&nbsp;Example 2: Redirect both '''[[Toprol XL]]''' and '''[[Toprolxl XL]]''' to '''[[Metoprolol succinate]]'''.


:&nbsp;&nbsp;'''4.2.2'''&nbsp;&nbsp; Make sure all uploaded pictures are appearing.
----


:&nbsp;&nbsp;'''4.2.3'''&nbsp;&nbsp; Remove extra line spaces and punctuation mistakes at the authorship field of each page.
'''''2.2&nbsp;&nbsp;Using the Drug Project Form'''''


===Step 5. Brand Name Microchapters===
----


====5.1 Creating the Brand Name Microchapters====
'''''2.2.1&nbsp;&nbsp;To create a drug page, Go to [[Form:DrugProjectForm]].'''''


:&nbsp;&nbsp;'''5.1.1'''&nbsp;&nbsp; Click on the name of one of the microchapters from the brand name home page.  You have reached a microchapters.  Make sure that only the first letter of the title of the page is capitalized.
'''''2.2.2&nbsp;&nbsp;Use the appropriate title for the drug page.'''''


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_brand_name_microchapter Example Brand Name Microchapter]'''.
: 2.2.2.1&nbsp;&nbsp;If there is more than one compound for a generic name, use the generic name with compound as the title.


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; Choose the appropriate information from the FDA package insert that fit the title of microchapter (eg: indications), copy it and paste it on the brand name microchapter.  Make sure to remove irrelevant content such as numbering.
:: 2.2.2.1.1&nbsp;&nbsp;Example 1: Use '''Metoprolol succinate''' as the title.


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; If the content of each microchapters can be divided into several parts, choose an appropriate subheading for each part and surround it with 3 equal signs.  Make sure that the first letter of each word of the subtitle is capitalized.
:: 2.2.2.1.2&nbsp;&nbsp;Example 2: Use '''Metoprolol tartrate''' as the title.


:&nbsp;&nbsp;'''5.1.3'''&nbsp;&nbsp; If the copied content contains ''[see (Section) XX.X]'', replace it with hyperlink to the corresponding microchapter.
: 2.2.2.2&nbsp;&nbsp;If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.


:&nbsp;&nbsp;'''5.1.4'''&nbsp;&nbsp; On the page '''Label and Packages''' create subheadings for each type of package label.  Under each subheading, retype the information provided on the Label and Packages of the FDA package insert and add the images in the same order of the FDA package insert.  Do not take a screenshot of texts but rather type them.  Refer to the [http://www.wikidoc.org/index.php/Lopressor_labels_and_packages Lopressor labels and package] page as an example.
:: 2.2.2.2.1&nbsp;&nbsp;Example 1: '''Metoprolol succinate and Hydrochlorothiazide''' as the title.


:&nbsp;&nbsp;'''5.1.5'''&nbsp;&nbsp; Obtain the url of the drug label from DailyMed.
:: 2.2.2.2.2&nbsp;&nbsp;Example 2: '''Metoprolol tartrate and Arginine''' as the title.


:&nbsp;&nbsp;'''5.1.6'''&nbsp;&nbsp; Create the reference wikicode and paste it back to the drug chapter.
'''''2.2.3&nbsp;&nbsp;Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.'''''


:&nbsp;&nbsp;'''5.1.7'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG CHAPTER.'''
'''''2.2.4&nbsp;&nbsp;Follow the instructions under each tab to create contents.'''''


:&nbsp;&nbsp;'''5.1.8'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page. Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in the alphabetical order.
'''''2.2.5&nbsp;&nbsp;Pasted information <u>MUST BE PLAIN TEXT</u> rather than formatted text.'''''


:&nbsp;&nbsp;'''5.1.9'''&nbsp;&nbsp; If the information for certain section is lacking, insert the following statement:
: 2.2.5.1&nbsp;&nbsp;Pasting as plain text may be done by the keyboard shortcut '''Ctrl+Shift+V''' in Windows OS (or '''Cmd+Shift+Opt+V''' in Mac OS).


:::&nbsp;&nbsp; '''''FDA Package Insert for (Drug) contains no information regarding (Section).'''''
: 2.2.5.2&nbsp;&nbsp;<u>DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE</u>.


====5.2 Black Box Warning====
'''''2.2.6&nbsp;&nbsp;Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.'''''


:&nbsp;&nbsp;'''5.2.1'''&nbsp;&nbsp; Boxed warning information must be placed in the '''Brand name black box warning''' microchapter.
'''''2.2.7&nbsp;&nbsp;Proofread and hyperlink after completing all sections.'''''


:&nbsp;&nbsp;'''5.2.2'''&nbsp;&nbsp; Use the following wikicode:
'''''2.2.8&nbsp;&nbsp;Add <nowiki>[[Category:Drug]]</nowiki> and other applicable categories in alphabetical order at the end.'''''


<table style="border: 1px solid black"><tr><td>
----
<pre>
{| style="border: 3px solid #696969;"
| style="background: #000000; border: 0px; padding: 20px 20px; width: 800px;" |
<center>
<font color="#F8F8FF">'''WARNING'''</font>
</center>


<center>
'''''2.3&nbsp;&nbsp;Contraindicated Medications in Specific Conditions'''''
<font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font>
</center>


----


<b><font color="#F8F8FF">
'''''2.3.1&nbsp;&nbsp;Harvest contraindications from the FDA drug label.'''''
* Item 1
* Item 2
* Item 2
</font></b>
|}
</pre>
</td></tr></table>


:&nbsp;&nbsp;'''4.2.3'''&nbsp;&nbsp; For instance, boxed warning alert for Toprol XL will appear as:
'''''2.3.2&nbsp;&nbsp;Go to the Medical Therapy chapter of each contraindication.'''''


{| style="border: 3px solid #696969;"
'''''2.3.3&nbsp;&nbsp;Place the following template before the ''References'' section.'''''
| style="background: #000000; border: 0px; padding: 20px 20px; width: 800px;" |
<div style="width: 500px;"><pre>
<center>
===Contraindicated Medications===
<font color="#F8F8FF">'''WARNING'''</font>
{{MedCondContrAbs
</center>
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}
</pre></div>


<center>
----
<font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font>
</center>


'''''2.4&nbsp;&nbsp;Adding Medications to the Causes Chapter of Significant Adverse Reactions'''''


<b><font color="#F8F8FF">
----
Following abrupt cessation of therapy with beta-blocking agents, exacerbations of angina pectoris and myocardial infarction have occurred. Warn patients against interruption or discontinuation of therapy without the physician’s advice.
</font></b>
|}


====5.3 Indications====
'''''2.4.1&nbsp;&nbsp;Harvest severe adverse reactions from the Warnings section of FDA drug label.'''''
:&nbsp;&nbsp;'''5.3.1'''&nbsp;&nbsp;In the indications microchapter, make sure to include the following two subheadings surrounded by two equal signs: '''FDA Labeled Indications''' and '''Off Label Indications'''.


:&nbsp;&nbsp;'''5.3.2'''&nbsp;&nbsp; Under '''FDA Labeled Indications''', copy the content from the FDA label.  Make sure that the content is categorized by the different types
'''''2.4.2&nbsp;&nbsp;For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.'''''


:&nbsp;&nbsp;'''5.3.3'''&nbsp;&nbsp; Under '''Off Label Indications''', include the following disclaimer sentence: '''''WikiDoc Drug Project is a constellation of drug information for healthcare providers and patients vigorously vetted on the basis of FDA package insert, MedlinePlus, Practice Guidelines, Scientific Statements, and scholarly medical literature. The information provided is not a medical advice or treatment. WikiDoc does not promote any medication or off-label use of drugs.''''' The disclaimer sentence should be in bold and italic.
'''''2.4.3&nbsp;&nbsp;Perform Chi-square calculations to determine the significance of adverse reactions. Outsource if necessary.'''''


:&nbsp;&nbsp;'''5.3.4'''&nbsp;&nbsp; Under '''Off Label Indications''', include a list of indications not approved by the FDA in the following order whenever applicable:
'''''2.4.4&nbsp;&nbsp;Add the medication to the Causes chapter of each significant adverse reaction.'''''
:::&nbsp;&nbsp; <nowiki> ====Adult==== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Acute===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Chronic===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Prophylaxis===== </nowiki>
:::&nbsp;&nbsp; <nowiki> ====Pediatrics==== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Acute===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Chronic===== </nowiki>
:::&nbsp;&nbsp; <nowiki> =====Prophylaxis===== </nowiki>


====5.4 Quality Checking the Brand Name Microchapters====
:&nbsp;&nbsp;'''5.4.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
:&nbsp;&nbsp;'''5.4.2'''&nbsp;&nbsp; Make sure all uploaded pictures are appearing.
:&nbsp;&nbsp;'''5.4.3'''&nbsp;&nbsp; Remove extra line spaces and punctuation mistakes at the authorship field of each page.
:&nbsp;&nbsp;'''5.4.4'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).  Search for the available categories on WikiDoc and try to add all the relevant ones to the page. Always include the category <nowiki>[[Category:Drugs]]</nowiki>.  Make sure all the categories are listed in the alphabetical order.
===Step 6. Completion===
====5.1 Fix all the errors before announcing the completion.====
====5.2 Update the status in the progress spreadsheet.====
====5.3 Submit the page for peer review.====
</div>
</div>
<div style="text-align: center;"><div style="width: 15em; margin: 0 auto; clear: both; white-space: nowrap; text-align: left;">
</div>
</div>
</div>
</div>
</div>

Latest revision as of 16:47, 18 December 2017

   Mission Statement   
   Tutorial   
   Editor's Checklist   

WikiDoc Drug Project — Tutorial

1.  Read before you proceed


1.1  Resources


1.1.1  DailyMed

1.1.1.1  DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.

1.1.2  Drugs@FDA

1.1.2.1  Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.

1.1.3  Pillbox

1.1.3.1  Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.
1.1.3.2  Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.
1.1.3.3  Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.

1.1.4  Drug Information Portal

1.1.4.1  Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).
1.1.4.2  For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)

1.1.5 MedlinePlus

1.1.5.1  MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.

1.2  Generic name, active ingredient, compound, combination, trade name, formulation, and label


1.2.1  What is the generic name?

1.2.1.1  Search and confirm the generic name of the drug.
1.2.1.2  Use the generic name as the title of the landing page.

1.2.2  What is the active ingredient? Is there more than one compound for the active ingredient?

1.2.2.1  Search and confirm the compound(s) of the active ingredient.
1.2.2.2  If there is more than one type of compound, place links (as <h3> headings) of each compound at the top of the landing page.

1.2.3  Is the active ingredient provided as combinations with other active ingredients?

1.2.3.1  If the active ingredient is also provided as combinations with other active ingredients, place links (as <h3> headings) of each combination at the top of the landing page.

1.2.4  What is the trade name?

1.2.4.1  Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.
1.2.4.2  Search and confirm the trade names for each combination (if any).
1.2.4.3  List the trade names of each compound and/or combination in parentheses.
1.2.4.4  Sort the list of compunds and/or combinations in alphabetical order.

1.2.5  What is the formulation?

1.2.5.1  Learn the concept of pharmaceutical formulations here.
1.2.5.2  Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.

1.2.6  Which label should be used?

1.2.6.1  Check the Marketing Start Date and the Revised date at the end of the label.
1.2.6.2  Choose the label that is most recently updated as a reference.

1.2.7  Example

For the generic name Metoprolol, there are two compounds of the active ingredient: metoprolol succinate and metoprolol tartrate.
Available compounds, combinations, and trade names of Metoprolol are as follows:
Metoprolol succinate (Toprol XL, Toprolxl XL)
Metoprolol succinate/Hydrochlorothiazide (Dutoprol)
Metoprolol tartrate (Lopressor)
Metoprolol tartrate/Arginine (Hypertensolol)
Metoprolol tartrate/Hydrochlorothiazide (Lopressor HCT)

2.  Creating or editing a drug page


2.1  Landing page


2.1.1  Go to the search page on WikiDoc.

2.1.2  Use the generic name or active ingredient as search terms.

2.1.3  The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.

2.1.3.1  Gather all available formulations here.
2.1.3.2  Create separate page for each available formulation.

2.1.4  At the top of the landing page, place the links (as <h3> headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).

2.1.4.1  <h3> headings should begin and end with three "=" symbols.
2.1.4.2  Example: ===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===

2.1.5  Redirect the trade name pages to its generic compound page.

2.1.5.1  Example 1: Redirect Lopressor to Metoprolol tartrate.
2.1.5.2  Example 2: Redirect both Toprol XL and Toprolxl XL to Metoprolol succinate.

2.2  Using the Drug Project Form


2.2.1  To create a drug page, Go to Form:DrugProjectForm.

2.2.2  Use the appropriate title for the drug page.

2.2.2.1  If there is more than one compound for a generic name, use the generic name with compound as the title.
2.2.2.1.1  Example 1: Use Metoprolol succinate as the title.
2.2.2.1.2  Example 2: Use Metoprolol tartrate as the title.
2.2.2.2  If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.
2.2.2.2.1  Example 1: Metoprolol succinate and Hydrochlorothiazide as the title.
2.2.2.2.2  Example 2: Metoprolol tartrate and Arginine as the title.

2.2.3  Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.

2.2.4  Follow the instructions under each tab to create contents.

2.2.5  Pasted information MUST BE PLAIN TEXT rather than formatted text.

2.2.5.1  Pasting as plain text may be done by the keyboard shortcut Ctrl+Shift+V in Windows OS (or Cmd+Shift+Opt+V in Mac OS).
2.2.5.2  DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE.

2.2.6  Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.

2.2.7  Proofread and hyperlink after completing all sections.

2.2.8  Add [[Category:Drug]] and other applicable categories in alphabetical order at the end.


2.3  Contraindicated Medications in Specific Conditions


2.3.1  Harvest contraindications from the FDA drug label.

2.3.2  Go to the Medical Therapy chapter of each contraindication.

2.3.3  Place the following template before the References section.

===Contraindicated Medications===
{{MedCondContrAbs
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}

2.4  Adding Medications to the Causes Chapter of Significant Adverse Reactions


2.4.1  Harvest severe adverse reactions from the Warnings section of FDA drug label.

2.4.2  For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.

2.4.3  Perform Chi-square calculations to determine the significance of adverse reactions. Outsource if necessary.

2.4.4  Add the medication to the Causes chapter of each significant adverse reaction.