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<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #a3b0bf; border-bottom: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project|Mission Statement]]&nbsp;&nbsp;&nbsp;</div>
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<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #CEDFF2; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project tutorial|Tutorial]]&nbsp;&nbsp;&nbsp;</div>
<div style="float:left; padding: .5ex 0; font-weight:bold; background-color:#dfe0e1; border:2px solid #a3b0bf; border-bottom: 0; font-size:90%">&nbsp;&nbsp;&nbsp;[[Drug project|Mission Statement]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project checklist|Editor's Checklist]]&nbsp;&nbsp;&nbsp;</div>
<div style="float:left; padding: .5ex 0; font-weight:bold; background-color:#cedff2; border:2px solid #999; border-bottom: 0; border-left: 0; font-size:90%">&nbsp;&nbsp;&nbsp;[[Drug project tutorial|Tutorial]]&nbsp;&nbsp;&nbsp;</div>
<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project list of medications|List of Medications]]&nbsp;&nbsp;&nbsp;</div>
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<div style="float: left; padding: .5ex 0; font-weight: bold; background-color: #DFE0E1; border: 2px solid #999; border-bottom: 0; border-left: 0; font-size: 90%">&nbsp;&nbsp;&nbsp;[[Drug project high-priority medications|High-Priority Medications]]&nbsp;&nbsp;&nbsp;</div>
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==WikiDoc Drug Project — Tutorial==
==WikiDoc Drug Project — Tutorial==


<BIG><BIG>'''''1.&nbsp;&nbsp;Read before you proceed'''''</BIG></BIG>


===Step 0. Formatting Basics===
----
 
====0.1 Pasting as Plain Text====
 
:&nbsp;&nbsp;'''0.1.1'''&nbsp;&nbsp; Pasting as plain text must be done by '''Ctrl+Shift+V''' in Windows OS (or '''Cmd+Shift+Opt+V''' in Mac OS).
 
:&nbsp;&nbsp;'''0.1.2'''&nbsp;&nbsp; '''DO NOT USE CTRL+V (OR CMD+V in Mac OS) TO PASTE.'''
 
====0.2 Removing Extra Line Spaces====
 
:&nbsp;&nbsp;'''0.2.1'''&nbsp;&nbsp; Phantom line spaces generated during copy-pasting commonly appear between paragraphs and at the top. Remove extra line spaces before moving onto the next page.
 
====0.3 Inserting Images for Tables, Graphs, and Packages====
 
:&nbsp;&nbsp;'''0.3.1'''&nbsp;&nbsp; The width of inserted images should be 600px unless otherwise indicated.
 
:&nbsp;&nbsp;'''0.3.2'''&nbsp;&nbsp; Use the following wikicode:
<table style="border: 1px solid black"><tr><td>
<pre>
{|
| [[File:NAMEOFTHEIMAGE01.png|thumb|600px]]
|}
</pre>
</td></tr></table>
 
 
===Step 1. Selecting Appropriate FDA Package Inserts===
 
====1.1 Generic Names, Trade Names, and Formulations====
 
:&nbsp;&nbsp;'''1.1.1'''&nbsp;&nbsp; Check the generic name, trade names, and formulations of the drug from both '''DailyMed''' and '''Drugs@FDA'''.
 
:&nbsp;&nbsp;'''1.1.2'''&nbsp;&nbsp; Confirm the presence of '''Original Packager''' label of each available formulation (solution/tablet/spray) from DailyMed.
 
:&nbsp;&nbsp;'''1.1.3'''&nbsp;&nbsp; Select the '''earliest available''' '''Original Packager''' label.  Avoid using '''Repackager''' labels.
 
:&nbsp;&nbsp;'''1.1.4'''&nbsp;&nbsp; Take Clopidogrel as an example:
 
:::&nbsp;&nbsp; '''Clopidogrel''' is the generic name.
 
:::&nbsp;&nbsp; '''Plavix''' is the trade name.
 
:::&nbsp;&nbsp; The earliest available Original Packager label is '''[http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01b14603-8f29-4fa3-8d7e-9d523f802e0b this.]'''


:::&nbsp;&nbsp; Redirect '''Plavix''' to the '''Clopidogrel''' main page.
'''''1.1&nbsp;&nbsp;Resources'''''


====1.2 When More Than One Formuation Exists====
----


:&nbsp;&nbsp;'''1.2.1'''&nbsp;&nbsp; Confirm the presence of '''Patient Information''' pages for different formulations on WikiDoc.
'''''1.1.1&nbsp;&nbsp;[http://dailymed.nlm.nih.gov/dailymed/about.cfm DailyMed]'''''


:&nbsp;&nbsp;'''1.2.2'''&nbsp;&nbsp; Place '''Patient Information''' links for different formulations between <nowiki>{{CMG}}</nowiki> and <nowiki>{{SB}}</nowiki>.
: 1.1.1.1&nbsp;&nbsp;DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.


:&nbsp;&nbsp;'''1.2.3'''&nbsp;&nbsp; Refer to [http://www.wikidoc.org/index.php/Sumatriptan Sumatriptan] as an example of a drug with multiple formulations.
'''''1.1.2&nbsp;&nbsp;[http://www.accessdata.fda.gov/Scripts/cder/drugsatfda/index.cfm Drugs@FDA]'''''


: 1.1.2.1&nbsp;&nbsp;Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.


===Step 2. Drug Template===
'''''1.1.3&nbsp;&nbsp;[http://pillbox.nlm.nih.gov/pillimage/search.php Pillbox]'''''


====2.1 Creating the Drug Template====
: 1.1.3.1&nbsp;&nbsp;Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.


:&nbsp;&nbsp;'''2.1.1'''&nbsp;&nbsp; Search '''Template:(generic name of the drug, capitalize the first letter)''' in the search field. (eg, Template:Clopidogrel)
: 1.1.3.2&nbsp;&nbsp;Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.


:&nbsp;&nbsp;'''2.1.2'''&nbsp;&nbsp; Click on '''Create the page "Template:(generic name of the drug)" on this wiki!'''&nbsp;&nbsp; which leads to an empty page.
: 1.1.3.3&nbsp;&nbsp;Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.  


:&nbsp;&nbsp;'''2.1.3'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_drug_template Example Drug Template]'''.
'''''1.1.4&nbsp;&nbsp;[http://druginfo.nlm.nih.gov/drugportal/ Drug Information Portal]'''''


:&nbsp;&nbsp;'''2.1.4'''&nbsp;&nbsp; Copy the code from the template and paste it back to the new drug template.  Replace XXXXX in the template by the generic name, YYYYY by the title in DailyMed and ZZZZZ (in the code) by the brand name you are using.  For example, in the [http://www.wikidoc.org/index.php/Metoprolol Metoprolol] page XXXXX corresponds to '''Metoprolol''', YYYYY corresponds to '''Lopressor (metoprolol tartrate) tablet''' and ZZZZZ corresponds to '''Lopressor'''.
: 1.1.4.1&nbsp;&nbsp;Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).


:&nbsp;&nbsp;'''2.1.5'''&nbsp;&nbsp; Replace the generic and trade names in the template you've created.
: 1.1.4.2&nbsp;&nbsp;For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)


:&nbsp;&nbsp;'''2.1.6'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG TEMPLATE.'''
'''''1.1.5 [http://www.nlm.nih.gov/medlineplus/druginformation.html MedlinePlus]'''''


====2.2 Quality Checking the Drug Template====
: 1.1.5.1&nbsp;&nbsp;MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.


:&nbsp;&nbsp;'''2.2.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
----


:&nbsp;&nbsp;'''2.2.2'''&nbsp;&nbsp; In case of multiple formulations, the links to chapters should start with the '''Trade names''' rather than the generic name.
'''''1.2&nbsp;&nbsp;Generic name, active ingredient, compound, combination, trade name, formulation, and label'''''


:&nbsp;&nbsp;'''2.2.3'''&nbsp;&nbsp; Refer to [http://www.wikidoc.org/index.php/Template:Sumatriptan Sumatriptan] as an example of a drug with multiple formulations.
----


'''''1.2.1&nbsp;&nbsp;What is the generic name?'''''


===Step 3. Drug Homepage===
: 1.2.1.1&nbsp;&nbsp;Search and confirm the generic name of the drug.


====3.1 Creating/Amending the Drug Homepage====
: 1.2.1.2&nbsp;&nbsp;Use the generic name as the title of the landing page.


:&nbsp;&nbsp;'''3.1.1'''&nbsp;&nbsp; Search the generic name of the drug in the search field.  You have reached the drug homepage.  Make sure that only the first letter of the name of the page is capitalized.
'''''1.2.2&nbsp;&nbsp;What is the active ingredient? Is there more than one compound for the active ingredient?'''''


:&nbsp;&nbsp;'''3.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_drug_homepage Example Drug Homepage]'''.
: 1.2.2.1&nbsp;&nbsp;Search and confirm the compound(s) of the active ingredient.


:&nbsp;&nbsp;'''3.1.3'''&nbsp;&nbsp; Copy the code from the example drug homepage and paste it back to the drug homepage.
: 1.2.2.2&nbsp;&nbsp;If there is more than one type of compound, place links (as &lt;h3&gt; headings) of each compound at the top of the landing page.


:&nbsp;&nbsp;'''3.1.4'''&nbsp;&nbsp; Replace XXXXX by the generic name, replace ZZZZZ by the trade name and replace YYYYY by the DailyMed name in the template you've created.  If more than one brand name is to be used, include their corresponding DailyMed name under the section '''FDA Package Insert''' and make sure to surround them by three equal signs.
'''''1.2.3&nbsp;&nbsp;Is the active ingredient provided as combinations with other active ingredients?'''''


:&nbsp;&nbsp;'''3.1.5'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG HOMEPAGE.'''
: 1.2.3.1&nbsp;&nbsp;If the active ingredient is also provided as combinations with other active ingredients, place links (as &lt;h3&gt; headings) of each combination at the top of the landing page.


:&nbsp;&nbsp;'''3.1.6'''&nbsp;&nbsp; Accommodate preexisting contents, if any, to the standard format.
'''''1.2.4&nbsp;&nbsp;What is the trade name?'''''


:&nbsp;&nbsp;'''3.1.7'''&nbsp;&nbsp; '''DO NOT REMOVE WORKS DONE BY PREVIOUS EDITORS.'''
: 1.2.4.1&nbsp;&nbsp;Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.


:&nbsp;&nbsp;'''3.1.8'''&nbsp;&nbsp; Include all trade names in <nowiki>{{SB}}</nowiki> and make proper redirections.  Make sure to seperate the brand names by a comma followed by a space. Make sure to capitalize the first letter of each brand name.
: 1.2.4.2&nbsp;&nbsp;Search and confirm the trade names for each combination (if any).


:&nbsp;&nbsp;'''3.1.9'''&nbsp;&nbsp; Place '''Patient Information''' link between <nowiki>{{CMG}}</nowiki> and <nowiki>{{SB}}</nowiki>.  Make sure that the sentences corresponding to <nowiki>{{CMG}}</nowiki>, patient information and <nowiki>{{SB}}</nowiki> are on different lines.
: 1.2.4.3&nbsp;&nbsp;List the trade names of each compound and/or combination in parentheses.


:&nbsp;&nbsp;'''3.1.10'''&nbsp;&nbsp; Visit MedlinePlus, if necessary, to collect data for Patient Information. To create Patient Information page for the drug, use the template '''[http://www.wikidoc.org/index.php/Drug_(patient_information) Example Drug (patient information)]'''.
: 1.2.4.4&nbsp;&nbsp;Sort the list of compunds and/or combinations in alphabetical order.


====3.2 The Headings on the Drug Homepage====
'''''1.2.5&nbsp;&nbsp;What is the formulation?'''''
:&nbsp;&nbsp;'''3.2.1'''&nbsp;&nbsp; The drug homepage should contain the following titles: Overview, Category, FDA Package Insert, Taking Alcohol with XXXXX and References.


:&nbsp;&nbsp;'''3.2.2'''&nbsp;&nbsp; In the Overview section, provide a short description of the drug.  It should include the name of the generic drug in the first sentence.  
: 1.2.5.1&nbsp;&nbsp;Learn the concept of pharmaceutical formulations '''[[Pharmaceutical formulation|here]]'''.


:&nbsp;&nbsp;'''3.2.3'''&nbsp;&nbsp; In the Category section, label the drug appropriately by adding one or more of the following:(...).  The categories should match the existing category pages on Wikidoc.  Make sure to separate the different categories by a comma followed by a space.  Make sure not to capitalize the words after coma.
: 1.2.5.2&nbsp;&nbsp;Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.


:&nbsp;&nbsp;'''3.2.4'''&nbsp;&nbsp; In the Taking Alcohol with XXXXX section:
'''''1.2.6&nbsp;&nbsp;Which label should be used?'''''
:::&nbsp;&nbsp;  Search the term '''Alcohol''' in the Package Insert on DailyMed.
:::&nbsp;&nbsp;  Place the information relating to combined alcohol use under the heading of '''Taking Alcohol with (Drug)'''.
:::&nbsp;&nbsp; If this information is lacking, insert the following statement: '''''Alcohol-(Drug) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.'''''


:&nbsp;&nbsp;'''3.2.5'''&nbsp;&nbsp; In the FDA Package insert, make sure you include subtitles with the DailyMed names of the brand names of the drug.  The subtitles should be surrounded by three equal signs.
: 1.2.6.1&nbsp;&nbsp;Check the ''Marketing Start Date'' and the ''Revised date'' at the end of the label.


:&nbsp;&nbsp;'''3.2.6'''&nbsp;&nbsp; In the Reference section, add the following: <nowiki>{{Reflist|2}} </nowiki> which allows the generation of references into two columns.
: 1.2.6.2&nbsp;&nbsp;Choose the label that is most recently updated as a reference.


====3.3 Quality Checking the Drug Homepage====
'''''1.2.7&nbsp;&nbsp;Example'''''


:&nbsp;&nbsp;'''3.4.1'''&nbsp;&nbsp; Headings must be arranged in proper order (Overview, Category, FDA Package Insert, Taking Alcohol with (Drug), etc).
: For the generic name '''Metoprolol''', there are two compounds of the active ingredient: '''metoprolol succinate''' and '''metoprolol tartrate'''.


:&nbsp;&nbsp;'''3.4.2'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).
: Available compounds, combinations, and trade names of '''Metoprolol''' are as follows:


:&nbsp;&nbsp;'''3.4.3'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
: '''[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])'''


: '''[[Metoprolol succinate/Hydrochlorothiazide]] ([[Dutoprol]])'''


: '''[[Metoprolol tartrate]] ([[Lopressor]])'''


===Step 4. Brand Name Chapters===
: '''[[Metoprolol tartrate/Arginine]] ([[Hypertensolol]])'''


====4.1 Creating the Brand Name Chapters====
: '''[[Metoprolol tartrate/Hydrochlorothiazide]] ([[Lopressor HCT]])'''


:&nbsp;&nbsp;'''4.1.1'''&nbsp;&nbsp; Search the brand name of the drug in the search field. You have reached the brand name homepage. Make sure that only the first letter of the name of the page is capitalized.
----


:&nbsp;&nbsp;'''4.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_brand_name_chapter Example Brand Name Chapter]'''.
<BIG><BIG>'''''2.&nbsp;&nbsp;Creating or editing a drug page'''''</BIG></BIG>


:&nbsp;&nbsp;'''4.1.3'''&nbsp;&nbsp; Copy the code from the example drug homepage and paste it back to a brand name chapter.
----


:&nbsp;&nbsp;'''4.1.4'''&nbsp;&nbsp; Replace ZZZZZ in the code by the brand name of the drug.
'''''2.1&nbsp;&nbsp;Landing page'''''


:&nbsp;&nbsp;'''4.1.5'''&nbsp;&nbsp; Make sure that the page starts with black box (more information on the coding is provided in section 4.2).  The black box should be followed by all the following subheadings: Indications and Usage, Dosage and Administration, Dosage Forms and Strengths, Contraindications, Warnings and Precautions, Adverse Reactions, Drug Interactions, Use in Specific Populations, Overdosage, Description, Clinical Pharmacology, Nonclinical Toxicology, Clinical Studies, How Supplied/Storage and Handling, Patient Counseling Information, Labels and Packages and Pill Images.
----


:&nbsp;&nbsp;'''4.1.6'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE BRAND NAME CHAPTER.'''
'''''2.1.1&nbsp;&nbsp;Go to the [http://www.wikidoc.org/index.php/Special:Search search] page on WikiDoc.'''''


:&nbsp;&nbsp;'''4.1.7'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).
'''''2.1.2&nbsp;&nbsp;Use the generic name or active ingredient as search terms.'''''


====4.2 Boxed Warning====
'''''2.1.3&nbsp;&nbsp;The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.'''''


:&nbsp;&nbsp;'''4.2.1'''&nbsp;&nbsp; Boxed warning information must be placed under the heading of '''FDA Package Insert''' on the drug homepage.
: 2.1.3.1&nbsp;&nbsp;Gather all available formulations [http://search.usa.gov/search?affiliate=usagov&query= here].


:&nbsp;&nbsp;'''4.2.2'''&nbsp;&nbsp; Use the following wikicode:
: 2.1.3.2&nbsp;&nbsp;Create separate page for each available formulation.


<table style="border: 1px solid black"><tr><td>
'''''2.1.4&nbsp;&nbsp;At the top of the landing page, place the links (as &lt;h3&gt; headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).'''''
<pre>
{| style="border: 3px solid #696969;"
| style="background: #000000; border: 0px; padding: 20px 20px; width: 800px;" |
<center>
<font color="#F8F8FF">'''WARNING'''</font>
</center>


<center>
: 2.1.4.1&nbsp;&nbsp;&lt;h3&gt; headings should begin and end with three "=" symbols.
<font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font>
</center>


: 2.1.4.2&nbsp;&nbsp;Example: <nowiki>===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===</nowiki>


<b><font color="#F8F8FF">
'''''2.1.5&nbsp;&nbsp;Redirect the trade name pages to its generic compound page.'''''
* Item 1
* Item 2
* Item 2
</font></b>
|}
</pre>
</td></tr></table>


:&nbsp;&nbsp;'''4.2.3'''&nbsp;&nbsp; For instance, boxed warning alert for Toprol XL will appear as:
: 2.1.5.1&nbsp;&nbsp;Example 1: Redirect '''[[Lopressor]]''' to '''[[Metoprolol tartrate]]'''.


{| style="border: 3px solid #696969;"
: 2.1.5.2&nbsp;&nbsp;Example 2: Redirect both '''[[Toprol XL]]''' and '''[[Toprolxl XL]]''' to '''[[Metoprolol succinate]]'''.
| style="background: #000000; border: 0px; padding: 20px 20px; width: 800px;" |
<center>
<font color="#F8F8FF">'''WARNING'''</font>
</center>


<center>
----
<font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font>
</center>


'''''2.2&nbsp;&nbsp;Using the Drug Project Form'''''


<b><font color="#F8F8FF">
----
Following abrupt cessation of therapy with beta-blocking agents, exacerbations of angina pectoris and myocardial infarction have occurred. Warn patients against interruption or discontinuation of therapy without the physician’s advice.
</font></b>
|}


====4.3 Quality Checking the Drug Chapters====
'''''2.2.1&nbsp;&nbsp;To create a drug page, Go to [[Form:DrugProjectForm]].'''''


:&nbsp;&nbsp;'''4.3.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
'''''2.2.2&nbsp;&nbsp;Use the appropriate title for the drug page.'''''


:&nbsp;&nbsp;'''4.3.2'''&nbsp;&nbsp; Make sure all uploaded pictures are appearing.
: 2.2.2.1&nbsp;&nbsp;If there is more than one compound for a generic name, use the generic name with compound as the title.


:&nbsp;&nbsp;'''4.3.3'''&nbsp;&nbsp; Remove extra line spaces and punctuation mistakes at the authorship field of each page.
:: 2.2.2.1.1&nbsp;&nbsp;Example 1: Use '''Metoprolol succinate''' as the title.


:: 2.2.2.1.2&nbsp;&nbsp;Example 2: Use '''Metoprolol tartrate''' as the title.


: 2.2.2.2&nbsp;&nbsp;If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.


===Step 5. Brand Name Micro-Chapters===
:: 2.2.2.2.1&nbsp;&nbsp;Example 1: '''Metoprolol succinate and Hydrochlorothiazide''' as the title.


:&nbsp;&nbsp;'''5.1.1'''&nbsp;&nbsp; Click on the name of one of the microchapters from the brand name home page.  You have reached a microchapters.  Make sure that only the first letter of the title of the page is capitalized.
:: 2.2.2.2.2&nbsp;&nbsp;Example 2: '''Metoprolol tartrate and Arginine''' as the title.


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; Go to '''[http://www.wikidoc.org/index.php/Sandbox_brand_name_microchapter Example Brand Name Microchapter]'''.
'''''2.2.3&nbsp;&nbsp;Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.'''''


:&nbsp;&nbsp;'''5.1.2'''&nbsp;&nbsp; Choose the appropriate information from the FDA package insert that fit the title of microchapter (eg: indications), copy it and paste it on the brand name microchapter.  Make sure to remove irrelevant content such as numbering.
'''''2.2.4&nbsp;&nbsp;Follow the instructions under each tab to create contents.'''''


:&nbsp;&nbsp;'''5.1.3'''&nbsp;&nbsp; If the copied content contains ''[see (Section) XX.X]'', replace it with hyperlink to the corresponding microchapter.
'''''2.2.5&nbsp;&nbsp;Pasted information <u>MUST BE PLAIN TEXT</u> rather than formatted text.'''''


:&nbsp;&nbsp;'''5.1.4'''&nbsp;&nbsp; Obtain the url of the drug label from DailyMed.
: 2.2.5.1&nbsp;&nbsp;Pasting as plain text may be done by the keyboard shortcut '''Ctrl+Shift+V''' in Windows OS (or '''Cmd+Shift+Opt+V''' in Mac OS).


:&nbsp;&nbsp;'''5.1.5'''&nbsp;&nbsp; Create the reference wikicode and paste it back to the drug chapter.
: 2.2.5.2&nbsp;&nbsp;<u>DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE</u>.


:&nbsp;&nbsp;'''5.1.6'''&nbsp;&nbsp; '''DO NOT REPLACE EXAMPLE DRUG CHAPTER.'''
'''''2.2.6&nbsp;&nbsp;Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.'''''


:&nbsp;&nbsp;'''5.1.7'''&nbsp;&nbsp; Apply appropriate categories at the bottom of the page (eg, <nowiki>[[Category:Cardiovascular Drugs]]</nowiki> and <nowiki>[[Category:Drugs]]</nowiki>).
'''''2.2.7&nbsp;&nbsp;Proofread and hyperlink after completing all sections.'''''


:&nbsp;&nbsp;'''5.1.8'''&nbsp;&nbsp; If the information for certain section is lacking, insert the following statement:
'''''2.2.8&nbsp;&nbsp;Add <nowiki>[[Category:Drug]]</nowiki> and other applicable categories in alphabetical order at the end.'''''


:::&nbsp;&nbsp;  '''''FDA Package Insert for (Drug) contains no information regarding (Section).'''''
----


'''''2.3&nbsp;&nbsp;Contraindicated Medications in Specific Conditions'''''


====5.2 Quality Checking the Brand Name Microchapters====
----


:&nbsp;&nbsp;'''4.2.1'''&nbsp;&nbsp; Fix any misspelling, punctuation error, or malfunctioning link.
'''''2.3.1&nbsp;&nbsp;Harvest contraindications from the FDA drug label.'''''


:&nbsp;&nbsp;'''4.2.2'''&nbsp;&nbsp; Make sure all uploaded pictures are appearing.
'''''2.3.2&nbsp;&nbsp;Go to the Medical Therapy chapter of each contraindication.'''''


:&nbsp;&nbsp;'''4.2.3'''&nbsp;&nbsp; Remove extra line spaces and punctuation mistakes at the authorship field of each page.
'''''2.3.3&nbsp;&nbsp;Place the following template before the ''References'' section.'''''
<div style="width: 500px;"><pre>
===Contraindicated Medications===
{{MedCondContrAbs
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}
</pre></div>


----


===Step 6. Completion===
'''''2.4&nbsp;&nbsp;Adding Medications to the Causes Chapter of Significant Adverse Reactions'''''


====5.1 Fix all the errors before announcing the completion.====
----


====5.2 Update the status in the progress spreadsheet.====
'''''2.4.1&nbsp;&nbsp;Harvest severe adverse reactions from the Warnings section of FDA drug label.'''''


====5.3 Submit the page for peer review.====
'''''2.4.2&nbsp;&nbsp;For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.'''''


'''''2.4.3&nbsp;&nbsp;Perform Chi-square calculations to determine the significance of adverse reactions.  Outsource if necessary.'''''


'''''2.4.4&nbsp;&nbsp;Add the medication to the Causes chapter of each significant adverse reaction.'''''


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Latest revision as of 16:47, 18 December 2017

   Mission Statement   
   Tutorial   
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WikiDoc Drug Project — Tutorial

1.  Read before you proceed


1.1  Resources


1.1.1  DailyMed

1.1.1.1  DailyMed is a public service provided by the National Library of Medicine (NLM) that encompasses FDA approved labels (package inserts) of marketed drugs.

1.1.2  Drugs@FDA

1.1.2.1  Drugs@FDA is a searchable catalog of FDA approved drug products (both prescription and over the counter) which is also useful for confirmation of the marketing status.

1.1.3  Pillbox

1.1.3.1  Pillbox is developed to aid in the identification of unknown pills (oral solid dosage form medications). It combines images of pills with appearance and other information to enable users to visually search for and identify oral solid dosage form medications.
1.1.3.2  Once a pill has been identified, additional information is provided, including brand/generic name, ingredients, and the National Drug File identification number.
1.1.3.3  Links are provided to NLM drug information resources, such as drug labels from DailyMed and the Drug Information Portal, which searches NIH and FDA drug information resources.

1.1.4  Drug Information Portal

1.1.4.1  Drug Information Portal provides links to information on breastfeeding (LactMed), drug-induced liver injury (LiverTox), manufacturers drug label (DailyMed), clinical trials (ClinicalTrials.gov), and drug Identification and Image Display (Pillbox beta).
1.1.4.2  For detailed information, it also provides links to reviewed biological and physical data (HSDB), references from scientific journals (Medline/PubMed), references from toxicological journals (TOXLINE), biological activities and chemical structures (PubChem), biological activities against HIV/AIDS and other viruses (NIAID ChemDB), toxicological and chemical resources (ChemIDplus), information from the US Food & Drug Administration (Drugs@FDA), and information from the US Drug Enforcement Administration (DEA)

1.1.5 MedlinePlus

1.1.5.1  MedlinePlus is a service of the National Library of Medicine (NLM) which contains information for drugs, herbs, and supplements.

1.2  Generic name, active ingredient, compound, combination, trade name, formulation, and label


1.2.1  What is the generic name?

1.2.1.1  Search and confirm the generic name of the drug.
1.2.1.2  Use the generic name as the title of the landing page.

1.2.2  What is the active ingredient? Is there more than one compound for the active ingredient?

1.2.2.1  Search and confirm the compound(s) of the active ingredient.
1.2.2.2  If there is more than one type of compound, place links (as <h3> headings) of each compound at the top of the landing page.

1.2.3  Is the active ingredient provided as combinations with other active ingredients?

1.2.3.1  If the active ingredient is also provided as combinations with other active ingredients, place links (as <h3> headings) of each combination at the top of the landing page.

1.2.4  What is the trade name?

1.2.4.1  Search and confirm the trade names for the generic name and its compounds. Please note that the trade name may be identical to the generic name in certain cases.
1.2.4.2  Search and confirm the trade names for each combination (if any).
1.2.4.3  List the trade names of each compound and/or combination in parentheses.
1.2.4.4  Sort the list of compunds and/or combinations in alphabetical order.

1.2.5  What is the formulation?

1.2.5.1  Learn the concept of pharmaceutical formulations here.
1.2.5.2  Search and confirm the formulations for the generic name and its compounds and combinations. Please note that different formulations may have identical trade names.

1.2.6  Which label should be used?

1.2.6.1  Check the Marketing Start Date and the Revised date at the end of the label.
1.2.6.2  Choose the label that is most recently updated as a reference.

1.2.7  Example

For the generic name Metoprolol, there are two compounds of the active ingredient: metoprolol succinate and metoprolol tartrate.
Available compounds, combinations, and trade names of Metoprolol are as follows:
Metoprolol succinate (Toprol XL, Toprolxl XL)
Metoprolol succinate/Hydrochlorothiazide (Dutoprol)
Metoprolol tartrate (Lopressor)
Metoprolol tartrate/Arginine (Hypertensolol)
Metoprolol tartrate/Hydrochlorothiazide (Lopressor HCT)

2.  Creating or editing a drug page


2.1  Landing page


2.1.1  Go to the search page on WikiDoc.

2.1.2  Use the generic name or active ingredient as search terms.

2.1.3  The generic name page should be organized as a landing page if there is more than one compound, combination, or formulation.

2.1.3.1  Gather all available formulations here.
2.1.3.2  Create separate page for each available formulation.

2.1.4  At the top of the landing page, place the links (as <h3> headings) of compounds, combinations, and formulations followed by trade names in parentheses (See Section 1.2 for instructions).

2.1.4.1  <h3> headings should begin and end with three "=" symbols.
2.1.4.2  Example: ===[[Metoprolol succinate]] ([[Toprol XL]], [[Toprolxl XL]])===

2.1.5  Redirect the trade name pages to its generic compound page.

2.1.5.1  Example 1: Redirect Lopressor to Metoprolol tartrate.
2.1.5.2  Example 2: Redirect both Toprol XL and Toprolxl XL to Metoprolol succinate.

2.2  Using the Drug Project Form


2.2.1  To create a drug page, Go to Form:DrugProjectForm.

2.2.2  Use the appropriate title for the drug page.

2.2.2.1  If there is more than one compound for a generic name, use the generic name with compound as the title.
2.2.2.1.1  Example 1: Use Metoprolol succinate as the title.
2.2.2.1.2  Example 2: Use Metoprolol tartrate as the title.
2.2.2.2  If there are combinations with other active ingredients, use the combination of each ingredient separated by the word "and" as the title.
2.2.2.2.1  Example 1: Metoprolol succinate and Hydrochlorothiazide as the title.
2.2.2.2.2  Example 2: Metoprolol tartrate and Arginine as the title.

2.2.3  Enter the title for the drug page in the field and left-click on the "Create or edit a Drug Page" button.

2.2.4  Follow the instructions under each tab to create contents.

2.2.5  Pasted information MUST BE PLAIN TEXT rather than formatted text.

2.2.5.1  Pasting as plain text may be done by the keyboard shortcut Ctrl+Shift+V in Windows OS (or Cmd+Shift+Opt+V in Mac OS).
2.2.5.2  DO NOT USE Ctrl+V (or Cmd+V in Mac OS) TO PASTE.

2.2.6  Left-click on the "Save page" button after completing each section to minimize the risk of losing progress.

2.2.7  Proofread and hyperlink after completing all sections.

2.2.8  Add [[Category:Drug]] and other applicable categories in alphabetical order at the end.


2.3  Contraindicated Medications in Specific Conditions


2.3.1  Harvest contraindications from the FDA drug label.

2.3.2  Go to the Medical Therapy chapter of each contraindication.

2.3.3  Place the following template before the References section.

===Contraindicated Medications===
{{MedCondContrAbs
|MedCond = NameOfTheContraindication|Drug1|Drug2|Drug3}}

2.4  Adding Medications to the Causes Chapter of Significant Adverse Reactions


2.4.1  Harvest severe adverse reactions from the Warnings section of FDA drug label.

2.4.2  For non-specific adverse reactions, compare the incidence in treatment and control groups from the Adverse Reactions section.

2.4.3  Perform Chi-square calculations to determine the significance of adverse reactions. Outsource if necessary.

2.4.4  Add the medication to the Causes chapter of each significant adverse reaction.