Drug allergy classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]

Drug Allergy
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Classification Based on Reaction Type

One type of classification of drug allergies, is based on the type of autoimmune process. This is the same type of classification that is used for other types of immunological reactions, and is based on the Gell and Coombs system.

• Type I hypersensitivity reaction: Immediate onset and primarily caused by the IgE, basophils, and degranulation of mast cells.
• Type II hypersensitivity reaction: Delayed onset reaction caused by antibodies, mediated by IgG mediated destruction of cells.
• Type III hypersensitivity reaction: Delayed in onset and caused by IgG immune complex formation and deposition, and complement activation.
• Type IV hypersensitivity reaction: T-cell mediated delayed onset reaction.