Disseminated intravascular coagulation causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are a variety of causes of DIC[1], all usually causing the release of chemicals into the blood that instigates the coagulation.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause.

Common Causes

Causes by Organ System

Cardiovascular Aortic aneurysm, Malignant hypertension, Myocardial infarction, Septic shock, Shock, Vasculitis
Chemical / poisoning Snake bite
Dermatologic No underlying causes
Drug Side Effect Amphetamine, Cocaine, Interleukin 2, Serotonin syndrome
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Acute fatty liver of pregnancy, Acute hepatic failure, Acute pancreatitis, Crohn disease, Liver disease, Ulcerative colitis
Genetic No underlying causes
Hematologic Paroxysmal nocturnal hemoglobinuria, Purpura fulminans, Acute myeloid leukemia, Acute promyelocytic leukemia
Iatrogenic Acute renal allograft rejection, Blood transfusion and complications, Denver shunt, Extensive surgery, LeVeen shunt, Peritoneovenous shunt, Prosthetic devices, Recent anesthesia, Reperfusion after liver transplantation, Ventricular assist devices
Infectious Disease Argentine hemorrhagic fever, Aspergillosis, Bolivian Hemorrhagic Fever, Capnocytophaga canimorsus, CMV, Hepatitis viruses, Histoplasmosis, Malaria (malignant tertian), Meningococcal septicaemia, Mycoplasma pneumoniae, Neisseria meningiditis, Neisseria meningitidis, Osteomyelitis, Rocky mountain spotted fever, Sarcoidosis, Sleeping sickness (East African), Streptococcus pneumoniae, Tuberculosis, Typhoid fever, Viral hemorrhagic fevers, VZV, Septic shock
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic Amniotic fluid embolism, Eclampsia, HELLP syndrome, Intrauterine death, Placental abruption, Pre-eclampsia, Retained intrauterine fetal demise
Oncologic Acute myeloid leukemia, Acute promyelocytic leukemia, Cancers of lung, pancreas, prostate and stomach, Giant hemangioma, Kasabach-Merritt syndrome, Mucin-secreting adenocarcinoma, Myeloproliferative syndromes, Paraneoplastic syndrome, Trousseau's syndrome
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Empyema
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Antiphospholipid syndrome, Macrophage activation syndrome, Raynaud disease, Rheumatoid arthritis
Sexual No underlying causes
Trauma Burns, Crush syndrome, Head injury, Lightning strike, Motor vehicle accidents, Severe tissue injury
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Heat stroke

Causes in Alphabetical Order


References

  1. Ledingham, J (2000). Concise Oxford Textbook of Medicine. Oxford University Press. ISBN 0-19-262870-4, Check |isbn= value: invalid character (help). Unknown parameter |coauthors= ignored (help)

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