Diaphragmatic paralysis medical therapy: Difference between revisions

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__NOTOC__
__NOTOC__
{{Diaphragmatic paralysis}}
{{Diaphragmatic paralysis}}
{{CMG}}; {{AE}}
{{CMG}}; {{AE}}{{MA}} [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu]


==Overview==
==Overview==
There is no treatment for [disease name]; the mainstay of therapy is supportive care.
No treatment is required for unilateral diaphragmatic paralysis because most patients are [[asymptomatic]]. In bilateral diaphragmatic paralysis treatment options are ventilatory support and diaphragmatic pacing.
 
OR
 
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].
 
OR
 
The majority of cases of [disease name] are self-limited and require only supportive care.
 
OR
 
[Disease name] is a medical emergency and requires prompt treatment.
 
OR
 
The mainstay of treatment for [disease name] is [therapy].
 
OR
 
The optimal therapy for [malignancy name] depends on the stage at diagnosis.
 
OR
 
[Therapy] is recommended among all patients who develop [disease name].
 
OR
 
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].
 
OR
 
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
 
OR
 
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].
 
OR
 
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].


==Medical Therapy==
==Medical Therapy==


==== Unilateral diaphragmatic paralysis ====
==== Unilateral diaphragmatic paralysis ====
* No treatment are required in unilateral diaphragmatic paralysis because most patients are asymptomatic.<ref name="pmid6849536">{{cite journal |vauthors=Easton PA, Fleetham JA, de la Rocha A, Anthonisen NR |title=Respiratory function after paralysis of the right hemidiaphragm |journal=Am. Rev. Respir. Dis. |volume=127 |issue=1 |pages=125–8 |date=January 1983 |pmid=6849536 |doi=10.1164/arrd.1983.127.1.125 |url=}}</ref>  
* No treatment are required in unilateral diaphragmatic paralysis because most patients are [[asymptomatic]].<ref name="pmid6849536">{{cite journal |vauthors=Easton PA, Fleetham JA, de la Rocha A, Anthonisen NR |title=Respiratory function after paralysis of the right hemidiaphragm |journal=Am. Rev. Respir. Dis. |volume=127 |issue=1 |pages=125–8 |date=January 1983 |pmid=6849536 |doi=10.1164/arrd.1983.127.1.125 |url=}}</ref>  
* Transient ventilatory support with noninvasive positive pressure ventilation (NPPV) or invasive mechanical ventilation:  it is used when patients with unilateral diaphragmatic paralysis develop acute respiratory dysfunction after general aneshesia or infections.   
* Transient ventilatory support with noninvasive positive pressure ventilation (NPPV) or invasive [[mechanical ventilation]]:  it is used when patients with unilateral diaphragmatic paralysis develop acute respiratory dysfunction after [[General anaesthesia|general anesthesia]] or [[infections]].   


==== Bilateral diaphragmatic paralysis ====
==== Bilateral diaphragmatic paralysis ====
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* Ventilatory support (invasive or noninvasive)
* Ventilatory support (invasive or noninvasive)
* Diaphragmatic pacing:  
* Diaphragmatic pacing:  
** It is done via stimilation of the diaphragm by implanted electrodes at the level of the neck or thorax. <ref name="pmid27195135">{{cite journal |vauthors=Le Pimpec-Barthes F, Legras A, Arame A, Pricopi C, Boucherie JC, Badia A, Panzini CM |title=Diaphragm pacing: the state of the art |journal=J Thorac Dis |volume=8 |issue=Suppl 4 |pages=S376–86 |date=April 2016 |pmid=27195135 |pmc=4856845 |doi=10.21037/jtd.2016.03.97 |url=}}</ref>
** It is done via stimulation of the [[diaphragm]] by implanted [[electrodes]] at the level of the [[neck]] or [[thorax]]. <ref name="pmid27195135">{{cite journal |vauthors=Le Pimpec-Barthes F, Legras A, Arame A, Pricopi C, Boucherie JC, Badia A, Panzini CM |title=Diaphragm pacing: the state of the art |journal=J Thorac Dis |volume=8 |issue=Suppl 4 |pages=S376–86 |date=April 2016 |pmid=27195135 |pmc=4856845 |doi=10.21037/jtd.2016.03.97 |url=}}</ref>
** It can not be done in patients with denervated diaphragams
** It can not be done in patients with denervated diaphragams.
** Best candidates for diaphragmatic pacing are patients with high level cervical cord injury.<ref name="pmid19067067">{{cite journal |vauthors=Onders RP, Elmo M, Khansarinia S, Bowman B, Yee J, Road J, Bass B, Dunkin B, Ingvarsson PE, Oddsdóttir M |title=Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients |journal=Surg Endosc |volume=23 |issue=7 |pages=1433–40 |date=July 2009 |pmid=19067067 |doi=10.1007/s00464-008-0223-3 |url=}}</ref>  
** Best candidates for diaphragmatic pacing are patients with high level [[Cervical Disc Disease|cervical cord injury]].<ref name="pmid19067067">{{cite journal |vauthors=Onders RP, Elmo M, Khansarinia S, Bowman B, Yee J, Road J, Bass B, Dunkin B, Ingvarsson PE, Oddsdóttir M |title=Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients |journal=Surg Endosc |volume=23 |issue=7 |pages=1433–40 |date=July 2009 |pmid=19067067 |doi=10.1007/s00464-008-0223-3 |url=}}</ref>  


* Antiviral therapy:  
===Diaphragmatic paralysis ===
[[Antiviral Therapy|Antiviral therapy]] for [[viral]] etiology of diaphragmatic paralysis:<ref name="pmid19277778">{{cite journal |vauthors=Crausman RS, Summerhill EM, McCool FD |title=Idiopathic diaphragmatic paralysis: Bell's palsy of the diaphragm? |journal=Lung |volume=187 |issue=3 |pages=153–7 |date= 2009 |pmid=19277778 |doi=10.1007/s00408-009-9140-z |url=}}</ref>
* '''Adult'''
** [[Valacyclovir]] 1000 mg twice daily for 1 week


*Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].
*Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
*Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].
*Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].
===Disease Name===


* '''1 Stage 1 - Name of stage'''
** 1.1 '''Specific Organ system involved 1'''
*** 1.1.1 '''Adult'''
**** Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)''' 
**** Preferred regimen (2): [[drug name]] 500 mg PO q8h for 14-21 days
**** Preferred regimen (3): [[drug name]] 500 mg q12h for 14-21 days
**** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days 
**** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
**** Alternative regimen (3): [[drug name]] 500 mg PO q6h for 14–21 days
*** 1.1.2 '''Pediatric'''
**** 1.1.2.1 (Specific population e.g. '''children < 8 years of age''')
***** Preferred regimen (1): [[drug name]] 50 mg/kg PO per day q8h (maximum, 500 mg per dose) 
***** Preferred regimen (2): [[drug name]] 30 mg/kg PO per day in 2 divided doses (maximum, 500 mg per dose)
***** Alternative regimen (1): [[drug name]]10 mg/kg PO q6h (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h (maximum, 500 mg per dose)
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
****1.1.2.2 (Specific population e.g. '<nowiki/>'''''children < 8 years of age'''''')
***** Preferred regimen (1): [[drug name]] 4 mg/kg/day PO q12h（maximum, 100 mg per dose）
***** Alternative regimen (1): [[drug name]] 10 mg/kg PO q6h (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h (maximum, 500 mg per dose) 
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
** 1.2 '''Specific Organ system involved 2'''
*** 1.2.1 '''Adult'''
**** Preferred regimen (1): [[drug name]] 500 mg PO q8h
*** 1.2.2  '''Pediatric'''
**** Preferred regimen (1): [[drug name]] 50 mg/kg/day PO q8h (maximum, 500 mg per dose)
* 2 '''Stage 2 - Name of stage'''
** 2.1 '''Specific Organ system involved 1 '''
**: '''Note (1):'''
**: '''Note (2)''':
**: '''Note (3):'''
*** 2.1.1 '''Adult'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
**** Oral regimen
***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days 
***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
*** 2.1.2 '''Pediatric'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
***** Alternative regimen (2):  [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day) '<nowiki/>'''''(Contraindications/specific instructions)''''''
**** Oral regimen
***** Preferred regimen (1):  [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Preferred regimen (2): [[drug name]] '''(for children aged ≥ 8 years)''' 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Alternative regimen (1):  [[drug name]] 10 mg/kg PO q6h 7–10 days  (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days  (maximum, 500 mg per dose)
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h for 14–21 days  (maximum,500 mg per dose)
** 2.2  '<nowiki/>'''''Other Organ system involved 2''''''
**: '''Note (1):'''
**: '''Note (2)''':
**: '''Note (3):'''
*** 2.2.1 '''Adult'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
**** Oral regimen
***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days 
***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
*** 2.2.2 '''Pediatric'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
***** Alternative regimen (2):  [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day)
**** Oral regimen
***** Preferred regimen (1):  [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Preferred regimen (2): [[drug name]] 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Alternative regimen (1):  [[drug name]] 10 mg/kg PO q6h 7–10 days  (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days  (maximum, 500 mg per dose)
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h for 14–21 days  (maximum,500 mg per dose)


==References==
==References==
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{{WH}}
{{WH}}
{{WS}}
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[[Category: (name of the system)]]
 
[[Category:Medicine]]
[[Category:Pulmonology]]
[[Category:Up-To-Date]]

Latest revision as of 21:22, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2] [3] [4] [5] [6]

Overview

No treatment is required for unilateral diaphragmatic paralysis because most patients are asymptomatic. In bilateral diaphragmatic paralysis treatment options are ventilatory support and diaphragmatic pacing.

Medical Therapy

Unilateral diaphragmatic paralysis

  • No treatment are required in unilateral diaphragmatic paralysis because most patients are asymptomatic.[1]
  • Transient ventilatory support with noninvasive positive pressure ventilation (NPPV) or invasive mechanical ventilation: it is used when patients with unilateral diaphragmatic paralysis develop acute respiratory dysfunction after general anesthesia or infections.

Bilateral diaphragmatic paralysis

  • Treatment options depends upon the severity of paralysis of the diaphragm and etiology. [2][3]
  • Ventilatory support (invasive or noninvasive)
  • Diaphragmatic pacing:

Diaphragmatic paralysis

Antiviral therapy for viral etiology of diaphragmatic paralysis:[6]


References

  1. ↑ Easton PA, Fleetham JA, de la Rocha A, Anthonisen NR (January 1983). "Respiratory function after paralysis of the right hemidiaphragm". Am. Rev. Respir. Dis. 127 (1): 125–8. doi:10.1164/arrd.1983.127.1.125. PMID 6849536.
  2. ↑ Davis J, Goldman M, Loh L, Casson M (January 1976). "Diaphragm function and alveolar hypoventilation". Q. J. Med. 45 (177): 87–100. PMID 1062815.
  3. ↑ Gibson GJ (November 1989). "Diaphragmatic paresis: pathophysiology, clinical features, and investigation". Thorax. 44 (11): 960–70. PMC 462156. PMID 2688182.
  4. ↑ Le Pimpec-Barthes F, Legras A, Arame A, Pricopi C, Boucherie JC, Badia A, Panzini CM (April 2016). "Diaphragm pacing: the state of the art". J Thorac Dis. 8 (Suppl 4): S376–86. doi:10.21037/jtd.2016.03.97. PMC 4856845. PMID 27195135.
  5. ↑ Onders RP, Elmo M, Khansarinia S, Bowman B, Yee J, Road J, Bass B, Dunkin B, Ingvarsson PE, Oddsdóttir M (July 2009). "Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients". Surg Endosc. 23 (7): 1433–40. doi:10.1007/s00464-008-0223-3. PMID 19067067.
  6. ↑ Crausman RS, Summerhill EM, McCool FD (2009). "Idiopathic diaphragmatic paralysis: Bell's palsy of the diaphragm?". Lung. 187 (3): 153–7. doi:10.1007/s00408-009-9140-z. PMID 19277778.

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