Dermatitis herpetiformis overview: Difference between revisions
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{{Dermatitis herpetiformis}} | {{Dermatitis herpetiformis}} | ||
{{CMG}} {{AE}} {{VVS}} | {{CMG}} {{AE}} {{VVS}} | ||
==Overview== | ==Overview== | ||
[[Dermatitis]] herpetiformis (DH) or Duhring's Disease, is a [[skin]] disorder often associated with [[celiac disease]]. It is a chronic, extremely itchy rash consisting of [[papule]]s and [[Vesicle (Biology)|vesicles]]. Dermatitis herpetiformis is associated with sensitivity of the intestine to gluten in the diet (celiac sprue). Dermatitis herpetiformis usually begins in the twenties, though children may sometimes be affected. It is seen in both men and women. Though the cause of the rash is unknown, dermatitis herpetiformis is frequently associated with [[gluten]] (a protein found in cereals) sensitivity in the small bowel. | [[Dermatitis]] herpetiformis (DH) or Duhring's Disease, is a [[skin]] disorder often associated with [[celiac disease]]. It is a chronic, extremely itchy rash consisting of [[papule]]s and [[Vesicle (Biology)|vesicles]]. Dermatitis herpetiformis is associated with sensitivity of the intestine to gluten in the diet (celiac sprue). Dermatitis herpetiformis usually begins in the twenties, though children may sometimes be affected. It is seen in both men and women. Though the cause of the rash is unknown, dermatitis herpetiformis is frequently associated with [[gluten]] (a protein found in cereals) sensitivity in the small bowel. | ||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differentiating Dermatitis Herpetiformis from Other Diseases== | |||
==Epidemiology and Demographics== | |||
==Risk Factors== | ==Risk Factors== | ||
Dermatitis herpetiformis usually begins in people age 20 and older, although children may sometimes be affected. It is seen in both men and women. | Dermatitis herpetiformis usually begins in people age 20 and older, although children may sometimes be affected. It is seen in both men and women. | ||
==Natural History, Complications and Prognosis | |||
==Diagnosis== | ==Diagnosis== | ||
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Dermatitis herpetiformis breakouts are usually extremely itchy. In many people the [[Vesicle (Biology)|vesicles]] or [[papule]]s appear on the elbows, knees, back, and buttocks (pressure points). It may also present as a patch of red skin with little water blisters scattered about. It is a systemic condition; the unpredictable skin rash may appear or be exacerbated by any irritation such as dry skin, scratching or clothing that is rough or scratchy. The fact that the rash is most prevalent at pressure points (where clothing rubs the most) may be why the symptoms sometimes appear to be symmetrical. | Dermatitis herpetiformis breakouts are usually extremely itchy. In many people the [[Vesicle (Biology)|vesicles]] or [[papule]]s appear on the elbows, knees, back, and buttocks (pressure points). It may also present as a patch of red skin with little water blisters scattered about. It is a systemic condition; the unpredictable skin rash may appear or be exacerbated by any irritation such as dry skin, scratching or clothing that is rough or scratchy. The fact that the rash is most prevalent at pressure points (where clothing rubs the most) may be why the symptoms sometimes appear to be symmetrical. | ||
===Physical Examination=== | |||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
A skin [[biopsy]] and direct [[immunofluorescence]] test of the skin are performed in most cases; doctors may additionally recommend a biopsy of the intestines. | A skin [[biopsy]] and direct [[immunofluorescence]] test of the skin are performed in most cases; doctors may additionally recommend a biopsy of the intestines. | ||
===CT Findings=== | |||
===MRI Findings=== | |||
===Other Imaging Findings=== | |||
==Treatment== | ==Treatment== | ||
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[[Dapsone]], an antibiotic, may help the majority of patients. A strict [[gluten-free diet]] will also be recommended to help control the disease. Adherence to this diet may eliminate the need for medications and prevent later complications. | [[Dapsone]], an antibiotic, may help the majority of patients. A strict [[gluten-free diet]] will also be recommended to help control the disease. Adherence to this diet may eliminate the need for medications and prevent later complications. | ||
===Surgery=== | |||
===Prevention=== | |||
==References== | ==References== | ||
Revision as of 20:06, 13 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vishnu Vardhan Serla M.B.B.S. [2]
Overview
Dermatitis herpetiformis (DH) or Duhring's Disease, is a skin disorder often associated with celiac disease. It is a chronic, extremely itchy rash consisting of papules and vesicles. Dermatitis herpetiformis is associated with sensitivity of the intestine to gluten in the diet (celiac sprue). Dermatitis herpetiformis usually begins in the twenties, though children may sometimes be affected. It is seen in both men and women. Though the cause of the rash is unknown, dermatitis herpetiformis is frequently associated with gluten (a protein found in cereals) sensitivity in the small bowel.
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Dermatitis Herpetiformis from Other Diseases
Epidemiology and Demographics
Risk Factors
Dermatitis herpetiformis usually begins in people age 20 and older, although children may sometimes be affected. It is seen in both men and women.
==Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Dermatitis herpetiformis breakouts are usually extremely itchy. In many people the vesicles or papules appear on the elbows, knees, back, and buttocks (pressure points). It may also present as a patch of red skin with little water blisters scattered about. It is a systemic condition; the unpredictable skin rash may appear or be exacerbated by any irritation such as dry skin, scratching or clothing that is rough or scratchy. The fact that the rash is most prevalent at pressure points (where clothing rubs the most) may be why the symptoms sometimes appear to be symmetrical.
Physical Examination
Laboratory Findings
A skin biopsy and direct immunofluorescence test of the skin are performed in most cases; doctors may additionally recommend a biopsy of the intestines.
CT Findings
MRI Findings
Other Imaging Findings
Treatment
Medical Therapy
Dapsone, an antibiotic, may help the majority of patients. A strict gluten-free diet will also be recommended to help control the disease. Adherence to this diet may eliminate the need for medications and prevent later complications.