|
|
| (27 intermediate revisions by 6 users not shown) |
| Line 1: |
Line 1: |
| __NOTOC__ | | __NOTOC__ |
| | '''For patient information, click [[Dermatitis herpetiformis (patient information)|here]]''' |
| | |
| {{Dermatitis herpetiformis}} | | {{Dermatitis herpetiformis}} |
| {{CMG}} | | {{CMG}}; {{AF}} {{KS}} |
| | |
| ==Overview==
| |
| | |
| [[Dermatitis]] herpetiformis (DH) or Duhring's Disease, is a [[skin]] disorder often associated with [[celiac disease]]. It is a chronic, extremely itchy rash consisting of [[papule]]s and [[Vesicle (Biology)|vesicles]]. Dermatitis herpetiformis is associated with sensitivity of the intestine to gluten in the diet (celiac sprue).
| |
|
| |
|
| Dermatitis herpetiformis usually begins in the twenties, though children may sometimes be affected. It is seen in both men and women. Though the cause of the rash is unknown, dermatitis herpetiformis is frequently associated with [[gluten]] (a protein found in cereals) sensitivity in the small bowel.
| | {{SK}} Duhring disease; Duhring-Brocq disease |
|
| |
|
| == Symptoms == | | ==[[Dermatitis herpetiformis overview|Overview]]== |
|
| |
| Dermatitis herpetiformis breakouts are usually extremely itchy. In many people the [[Vesicle (Biology)|vesicles]] or [[papule]]s appear on the elbows, knees, back, and buttocks (pressure points). It may also present as a patch of red skin with little water blisters scattered about. It is a systemic condition; the unpredictable skin rash may appear or be exacerbated by any irritation such as dry skin, scratching or clothing that is rough or scratchy. The fact that the rash is most prevalent at pressure points (where clothing rubs the most) may be why the symptoms sometimes appear to be symmetrical. | |
|
| |
|
| == Signs and tests == | | ==[[Dermatitis herpetiformis historical perspective|Historical Perspective]]== |
|
| |
|
| A skin [[biopsy]] and direct [[immunofluorescence]] test of the skin are performed in most cases; doctors may additionally recommend a biopsy of the intestines.
| | ==[[Dermatitis herpetiformis classification|Classification]]== |
|
| |
|
| == Treatment == | | ==[[Dermatitis herpetiformis pathophysiology|Pathophysiology]]== |
|
| |
|
| [[Dapsone]], an antibiotic, may help the majority of patients. | | ==[[Dermatitis herpetiformis causes|Causes]]== |
|
| |
|
| A strict [[gluten-free diet]] will also be recommended to help control the disease. Adherence to this diet may eliminate the need for medications and prevent later complications.
| | ==[[Differentiating dermatitis herpetiformis from other diseases|Differentiating Dermatitis herpetiformis from other Diseases]]== |
|
| |
|
| == Social impact == | | ==[[Dermatitis herpetiformis epidemiology and demographics|Epidemiology and Demographics]]== |
| The lifelong diet can be difficult and socially troublesome, especially in young patients, but it is crucial in order to avoid serious health consequences. Teenagers in particular occasionally rebel against the dietary strictures and suffer relapses or complications as a result. The widespread use of wheat byproducts in prepared food, soups and sauces can make dining out problematic. This is especially true in the United States, where dermatitis herpetiformis disease is less widely-known among the wider population than it is in Europe. However, certain types of restaurant (e.g., Japanese, Thai, Indian, and Latin American) already offer a wide range of gluten-free menu options, and many major restaurant chains have responded to growing awareness of celiac disease (and by default dermatitis herpetiformis) by posting information about the gluten content of their menu items on their websites.
| |
|
| |
|
| It is important for friends and family to understand that dermatitis herpetiformis is present for life.
| | ==[[Dermatitis herpetiformis risk factors|Risk Factors]]== |
|
| |
|
| As [[celiac disease]] has become better understood, the availability of gluten-free replacements for everyday treats such as muffins, bagels, pasta and the like has continually improved, as has their quality. This has also benefited those with dermatitis herpetiformis.
| | ==[[Dermatitis herpetiformis natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
| People with dermatitis herpetiformis and/or celiac cannot eat only gluten-free foods but continue to consume one or two products that contain gluten. For example, drinking beer can still cause symptoms, but even this problem may now be overcome. There are many specialty brews around the world that may be described as gluten free beer.
| |
|
| |
|
| However, the case of beer raises the main problem of dermatitis herpetiformis and celiac disease: while the diet is strict and the effects of the disease are serious, the main symptom of the disease can be social isolation with those with Dermatitis herpetiformis afraid to become involved in normal social life. Parties can be difficult, weddings and funerals hard, holidays awkward, a meal out a nightmare, travel is made more stressful, and even the trip to a bar or pub one that requires the individual to be constantly aware of the disease. It is too easy for the coeliacs and those with dermatitis herpetiformis to withdraw from these normal activities, and many people with these complaints are working to create normal activities where they can forget the problem. It is important for newly diagnosed with either dermatitis herpetiformis or celiacs to ensure that they remain involved in their social life and explain their needs to family and friends.
| | ==Diagnosis== |
| | [[Dermatitis herpetiformis history and symptoms|History and Symptoms]] | [[Dermatitis herpetiformis physical examination|Physical Examination]] | [[Dermatitis herpetiformis laboratory findings|Laboratory Findings]] | [[Dermatitis herpetiformis CT|CT]] | [[Dermatitis herpetiformis MRI|MRI]] | [[Dermatitis herpetiformis other imaging findings|Other Imaging Findings]] | [[Dermatitis herpetiformis other diagnostic studies|Other Diagnostic Studies]] |
| | ==Treatment== |
| | [[Dermatitis herpetiformis medical therapy|Medical Therapy]] | [[Dermatitis herpetiformis primary prevention|Primary Prevention]] | [[Dermatitis herpetiformis secondary prevention|Secondary Prevention]] | [[Dermatitis herpetiformis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Dermatitis herpetiformis future or investigational therapies|Future or Investigational Therapies]] |
|
| |
|
| ==Special foods == | | ==Case Studies== |
|
| |
|
| Although these diseases may tend to isolate individuals with the complaint, the situation is becoming less difficult year by year. Manufacturers are now making a wide range of very acceptable breads, and some pastas (notoriously horrible in the past) are virtually indistinguishable from "normal" pasta. Restaurants are beginning to offer gluten free menus and are recognising the size of the market that is largely not catered for. Coeliacs and those with dermatitis herpetiformis should not be afraid to ask establishments how they can cater for them. Where the question has been asked repeatedly, the proprietors tend to recognise the need, and become aware of the revenue that is lost where they do not provide a full range of products.
| | [[Dermatitis herpetiformis case study one|Case #1]] |
|
| |
|
| In many ways beer seems to be the hardest gluten free product to "get right". However, [[gluten-free beer]] is now available and there is now a range of ales, beers, and lagers to choose from. Around the world standards of "gluten free" vary. For example, while in the United Kingdom a beer with less than 20 parts per million gluten (20ppm) is "gluten free", in Australia it is not possible to describe any product as such if any gluten can be detected at all. Similarly, some "gluten free" breads can contain low levels of gluten in one country, in another they would contravene labelling or food standards legislation.
| | ==Related Chapters== |
| | |
| However, while large scale commercial beers are out of the question for those who cannot consume gluten<ref>{{cite web
| |
| | Carolyn Smagalski
| |
| | date = 2006
| |
| | url = http://www.bellaonline.com/articles/art40157.asp
| |
| | title = Ask the Beer Fox - Is Straub's Beer Gluten Free ?
| |
| | publisher = Carolyn Smagalski, Bella Online
| |
| }}
| |
| </ref>
| |
| <ref>
| |
| {{cite web
| |
| | Carolyn Smagalski
| |
| | date = 2006
| |
| | url = http://www.bellaonline.com/articles/art41529.asp
| |
| | title = Is Nigerian Guinness Gluten Free ?
| |
| | publisher = Carolyn Smagalski, Bella Online
| |
| }}
| |
| </ref>
| |
| <ref>
| |
| {{cite web
| |
| | Carolyn Smagalski
| |
| | date = 2006
| |
| | url = http://www.glutenfreebeerfestival.com/mainstream.html
| |
| | title = Ask the Beer Fox – Is Standard Lager Beer Safe for Coeliacs?
| |
| | publisher = Carolyn Smagalski, www.glutenfreebeerfestival.com
| |
| }}
| |
| </ref> (regardless of the sometimes misleading advice on some brewery websites), it is likely that most people with dermatitis herpetiformis coeliacs will be able to drink beer at under 20ppm (in moderation) without causing themselves any harm. It is important, however, for consumers of all "low gluten" foods and beverages to tell their consultant, and to ensure that even if the obvious symptoms are absent, there are no other negative effects continuing that they are unaware of.
| |
| | |
| However, the development of a range of gluten free beers is an example of those who cannot consume gluten "working together to socialize normally and avoid isolation caused by their special dietary needs. It also represents part of the return to a ‘normal’ life"<ref>
| |
| {{cite web
| |
| | Robert La France
| |
| | date = 2006
| |
| | url = http://www.glutenfreeda.com/may06_gf-beer.asp
| |
| | title = First-Ever Gluten-Free Beer Festival Quenches Celiacs’ Thirst
| |
| | publisher = Robert La France, Glutenfreeda.com
| |
| }}
| |
| </ref>.
| |
| | |
| == References ==
| |
| {{reflist|2}}
| |
| | |
| ==See also==
| |
| *[[Gluten-free, casein-free diet]] | | *[[Gluten-free, casein-free diet]] |
| *Coeliacs
| |
| *Gluten free beer
| |
| *[[Gluten-free diet]] | | *[[Gluten-free diet]] |
|
| |
|
| == External links == | | == References == |
| * Pictures: [http://www.tidsskriftet.no/lts-img/2003/L03-22-Med-20-01.jpg ELBOW] [http://www.aafp.org/afp/980301ap/prue_f8.jpg ARMS]
| | <references/> |
| * [http://www.triumphdining.com/ Gluten Free Restaurant Guide by Triumph Dining]
| |
| * [http://www.glutenfreebeerfestival.com/ glutenfreebeerfestival.com - a site that reviews gluten free beers]
| |
| * {{DermNet|immune/dermatitis-herpetiformis}}
| |
|
| |
|
| {{Vesiculobullous disease}} | | {{Vesiculobullous disease}} |
| {{Diseases of the skin and subcutaneous tissue}} | | {{Diseases of the skin and subcutaneous tissue}} |
| [[Category:Dermatology]]
| |
| [[Category:Primary care]]
| |
|
| |
| <br> | | <br> |
| [[de:Dermatitis herpetiformis Duhring]] | | [[de:Dermatitis herpetiformis Duhring]] |
| Line 104: |
Line 51: |
| {{WikiDoc Help Menu}} | | {{WikiDoc Help Menu}} |
| {{WikiDoc Sources}} | | {{WikiDoc Sources}} |
| | |
| | [[Category:Dermatology]] |
| | [[Category:Skin diseases]] |
| | [[Category:Disease]] |
| | [[Category:Immunology]] |
| | [[Category:Allergology]] |