Crohn's disease risk factors: Difference between revisions

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==Overview==
==Overview==
Common [[risk factors]] in the development of crohns disease include white ancestry, age 15-40 or 60-80 years, family history of crohns disease and [[cigarette smoking]].
==Risk Factors==
==Risk Factors==
Although the cause of Crohn's disease is not known, it is believed to be an [[autoimmunity|autoimmune disease]] that is [[genetics|genetically]] linked. The highest relative risk occurs in siblings, affecting males and females equally. Smokers are three times more likely to get Crohn's disease.
Common risk factors in the development of crohns disease include <ref>{{cite journal | author = Cosnes J | title = Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice. | journal = Best Pract Res Clin Gastroenterol | volume = 18 | issue = 3 | pages = 481-96 | year = 2004 | id = PMID 15157822}}</ref><ref>{{cite journal|last=Morris|first= Danielle L|date=2000-11-18|title=Early environmental factors may have role in both Crohn's disease and gastric carcinoma - Letter to the Editor|journal=British Medical Journal|url=http://findarticles.com/p/articles/mi_m0999/is_7271_321/ai_67708495/|accessdate=2008-01-16}}</ref><ref><!--  
 
** -->{{cite journal | author = Lesko S, Kaufman D, Rosenberg L, ''et al.'' | title = Evidence for an increased risk of Crohn's disease in oral contraceptive users. | journal = Gastroenterology | volume = 89 | issue = 5 | pages = 1046-9 | year = 1985 | id = PMID 4043662}}</ref>
Unlike the other major type of IBD, [[ulcerative colitis]], there is no known medical or [[surgery|surgical]] cure for Crohn's disease.<ref>{{cite web|first= M Bashar|last= Al-Ataie|coauthors=Vishwanath N Shenoy|publisher=eMedicine|title=Ulcerative colitis|url=http://www.emedicine.com/med/topic2336.htm|accessdate=2006-07-02|
*White ancestry
date=2005-10-04}}</ref> Instead, a number of medical treatments are utilized with the goal of putting and keeping the disease in [[remission (medicine)|remission]].  These include [[mesalazine|5-aminosalicylic acid]] (5-ASA) formulations (Pentasa capsules, Asacol tablets, Lialda tablets, Rowasa retention enemas), [[prednisone|steroid]] medications, immunomodulators (such as [[azathioprine]], [[mercaptopurine]] (6-MP), and [[methotrexate]]), and newer [[biological therapy for inflammatory bowel disease|biological]] medications, such as [[infliximab]] (Remicade) and [[adalimumab]] (Humira).<ref name=Podolsky>{{Cite journal|last=Podolsky|first= Daniel K.|title=Inflammatory bowel disease|journal=New England Journal of Medicine|month=August|year=2002|volume=346|issue=6|pages=417-29
*Age 15-40 or 60-80 years
|url=http://content.nejm.org/cgi/content/extract/347/6/417|accessdate=2006-07-02|id=PMID 12167685}}</ref>Also in January 2008 the U.S. Food and Drug Administration approved a new biologic known as [[natalizumab]] (Tysabri) for both induction of remission and maintenance of remission in moderate and severe Crohns Disease.
*Family history of CD
 
*[[Cigarette smoking]], smokers are three times more likely to get Crohn's disease.
Ethnic background is also a risk factor. Until very recently, whites and European Jews accounted for the vast majority of the cases in the United States, and in most industrialized countries, this demographic is still true.
*Diet rich in sugars
*[[Oral contraceptives]]
*[[NSAIDS]]
*Living in an industrialized country
*Certain chemicals in the diet, known as microparticles, are also hypothesized as a risk factor for the disease, as well as a poor imbalance of omega-6 to healthy [[omega-3 fatty acids]] that emerging research shows helps to improve all types of inflammatory disease.
*[[Gastric cancer]] is most often caused by the bacterium [[Helicobacter pylori]] that flourishes in cramped and unsanitary conditions.


==References==
==References==
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[[Category:Needs overview]]
[[Category:Disease]]
[[Category:Autoimmune diseases]]
[[Category:Digestive diseases]]
[[Category:Gastroenterology]]
[[Category:Genetic disorders]]
[[Category:Inflammations]]
[[Category:Conditions diagnosed by stool test]]
[[Category:Abdominal pain]]

Latest revision as of 21:10, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Common risk factors in the development of crohns disease include white ancestry, age 15-40 or 60-80 years, family history of crohns disease and cigarette smoking.

Risk Factors

Common risk factors in the development of crohns disease include [1][2][3]

  • White ancestry
  • Age 15-40 or 60-80 years
  • Family history of CD
  • Cigarette smoking, smokers are three times more likely to get Crohn's disease.
  • Diet rich in sugars
  • Oral contraceptives
  • NSAIDS
  • Living in an industrialized country
  • Certain chemicals in the diet, known as microparticles, are also hypothesized as a risk factor for the disease, as well as a poor imbalance of omega-6 to healthy omega-3 fatty acids that emerging research shows helps to improve all types of inflammatory disease.
  • Gastric cancer is most often caused by the bacterium Helicobacter pylori that flourishes in cramped and unsanitary conditions.

References

  1. Cosnes J (2004). "Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice". Best Pract Res Clin Gastroenterol. 18 (3): 481–96. PMID 15157822.
  2. Morris, Danielle L (2000-11-18). "Early environmental factors may have role in both Crohn's disease and gastric carcinoma - Letter to the Editor". British Medical Journal. Retrieved 2008-01-16.
  3. Lesko S, Kaufman D, Rosenberg L; et al. (1985). "Evidence for an increased risk of Crohn's disease in oral contraceptive users". Gastroenterology. 89 (5): 1046–9. PMID 4043662.

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