Crohn's disease natural history, complications and prognosis: Difference between revisions

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==Overview==
==Overview==
If left untreated, patients with Crohn's disease can progress into colorectal cancer depending upon the region involved. The common complication of Crohn's disease include obstructions, abscesses, free perforation, and hemorrhage. With treatment, most people achieve a healthy life, and the mortality rate for the disease is low.
If left untreated, patients with Crohn's disease can progress into colorectal cancer depending upon the region involved. The common complication of Crohn's disease include obstructions, abscesses, free perforation, and hemorrhage. With treatment, most people achieve a healthy life, and the mortality rate for the disease is low.
==Natural History==
==Natural History==
If left untreated, patients with Crohn's disease can progress into colorectal cancer depending upon the region involved. For example, individuals with Crohn's disease involving the [[small bowel]] are at higher risk for [[Small intestine cancer|small intestinal cancer]]. Similarly, people with Crohn's [[colitis]] have a [[relative risk]] of 5.6 for developing [[colon cancer]].<ref>{{cite journal |author=Ekbom A, Helmick C, Zack M, Adami H |title=Increased risk of large-bowel cancer in Crohn's disease with colonic involvement |journal=Lancet |volume=336 |issue=8711 |pages=357-9 |year=1990 |pmid=1975343}}</ref> Screening for colon cancer with [[colonoscopy]] is recommended for anyone who has had Crohn's colitis for eight years, or more.<ref>{{cite journal | author = Collins P, Mpofu C, Watson A, Rhodes J | title = Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease | journal = Cochrane Database Syst Rev | volume = | issue = | pages = CD000279 | year = | id = PMID 16625534}}</ref><ref>{{cite web|url=https://www.livingwithcrohnsdisease.com/livingwithcrohnsdisease/crohns_disease/complications_of_crohns.html|title=Complications of Crohn's Disease|accessdate=2008-01-16}}</ref><ref>{{cite journal |author=Ekbom A, Helmick C, Zack M, Adami H |title=Increased risk of large-bowel cancer in Crohn's disease with colonic involvement |journal=Lancet |volume=336 |issue=8711 |pages=357-9 |year=1990 |pmid=1975343}}</ref>
If left untreated, patients with Crohn's disease can progress into colorectal cancer depending upon the region involved. For example, individuals with Crohn's disease involving the [[small bowel]] are at higher risk for [[Small intestine cancer|small intestinal cancer]]. Similarly, people with Crohn's [[colitis]] have a [[relative risk]] of 5.6 for developing [[colon cancer]].<ref>{{cite journal |author=Ekbom A, Helmick C, Zack M, Adami H |title=Increased risk of large-bowel cancer in Crohn's disease with colonic involvement |journal=Lancet |volume=336 |issue=8711 |pages=357-9 |year=1990 |pmid=1975343}}</ref> Screening for colon cancer with [[colonoscopy]] is recommended for anyone who has had Crohn's colitis for eight years, or more.<ref>{{cite journal | author = Collins P, Mpofu C, Watson A, Rhodes J | title = Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease | journal = Cochrane Database Syst Rev | volume = | issue = | pages = CD000279 | year = | id = PMID 16625534}}</ref><ref>{{cite web|url=https://www.livingwithcrohnsdisease.com/livingwithcrohnsdisease/crohns_disease/complications_of_crohns.html|title=Complications of Crohn's Disease|accessdate=2008-01-16}}</ref><ref>{{cite journal |author=Ekbom A, Helmick C, Zack M, Adami H |title=Increased risk of large-bowel cancer in Crohn's disease with colonic involvement |journal=Lancet |volume=336 |issue=8711 |pages=357-9 |year=1990 |pmid=1975343}}</ref>
==Complications==
==Complications==
Common complications of Crohn's disease include:<ref>{{cite web|url=https://www.livingwithcrohnsdisease.com/livingwithcrohnsdisease/crohns_disease/complications_of_crohns.html|title=Complications of Crohn's Disease|accessdate=2008-01-16}}</ref>
Common complications of Crohn's disease include:<ref>{{cite web|url=https://www.livingwithcrohnsdisease.com/livingwithcrohnsdisease/crohns_disease/complications_of_crohns.html|title=Complications of Crohn's Disease|accessdate=2008-01-16}}</ref>
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==References==
==References==
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[[Category:Conditions diagnosed by stool test]]
[[Category:Abdominal pain]]
[[Category:Abdominal pain]]
[[Category:Primary care]]
[[Category:Needs overview]]
[[Category:Needs overview]]
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Latest revision as of 21:10, 29 July 2020

Crohn's disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

If left untreated, patients with Crohn's disease can progress into colorectal cancer depending upon the region involved. The common complication of Crohn's disease include obstructions, abscesses, free perforation, and hemorrhage. With treatment, most people achieve a healthy life, and the mortality rate for the disease is low.

Natural History

If left untreated, patients with Crohn's disease can progress into colorectal cancer depending upon the region involved. For example, individuals with Crohn's disease involving the small bowel are at higher risk for small intestinal cancer. Similarly, people with Crohn's colitis have a relative risk of 5.6 for developing colon cancer.[1] Screening for colon cancer with colonoscopy is recommended for anyone who has had Crohn's colitis for eight years, or more.[2][3][4]

Complications

Common complications of Crohn's disease include:[5]

Prognosis

  • Crohn's disease is a chronic condition for which there is currently no cure. It is characterized by periods of improvement followed by episodes when symptoms flare up.
  • With treatment, most people achieve a healthy life, and the mortality rate for the disease is low.
  • Crohn's disease is associated with an increased risk of small bowel and colorectal carcinoma.[7]
  • Many patients will have temporary stoma formations together with possible associated complications.[8]

References

  1. Ekbom A, Helmick C, Zack M, Adami H (1990). "Increased risk of large-bowel cancer in Crohn's disease with colonic involvement". Lancet. 336 (8711): 357–9. PMID 1975343.
  2. Collins P, Mpofu C, Watson A, Rhodes J. "Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease". Cochrane Database Syst Rev: CD000279. PMID 16625534.
  3. "Complications of Crohn's Disease". Retrieved 2008-01-16.
  4. Ekbom A, Helmick C, Zack M, Adami H (1990). "Increased risk of large-bowel cancer in Crohn's disease with colonic involvement". Lancet. 336 (8711): 357–9. PMID 1975343.
  5. "Complications of Crohn's Disease". Retrieved 2008-01-16.
  6. Evans J, Steinhart A, Cohen Z, McLeod R (2003). "Home total parenteral nutrition: an alternative to early surgery for complicated inflammatory bowel disease". J Gastrointest Surg. 7 (4): 562–6. PMID 12763417.
  7. Canavan, C. (2006). "Meta-analysis : colorectal and small bowel cancer risk in patients with Crohn's disease". Alimentary pharmacology & therapeutics. 23 (8): 1097–1104. ISSN 0269-2813. Retrieved 2007-05-23.
  8. http://www.answers.com/topic/crohn-s-disease?cat=health

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