Cretinism medical therapy: Difference between revisions

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==Overview==
==Overview==
The mainstay of treatment for cretinism is thyroid hormone replacement therapy. Levothyroxine (L-T4) is administrated orally to patients with cretinism.  
The mainstay of treatment for cretinism is thyroid hormone replacement therapy. [[levothyroxine]] (L-T4) is administrated orally to patients with cretinism.  


==Medical Therapy==
==Medical Therapy==
*Patients with cretinism are treated with thyroid hormone replacement therapy.  
*Patients with cretinism are treated with thyroid hormone replacement therapy.  
*Endocrine society recommended with the appropriate quick initiation of levothyroxine as the mainstay treatment of cretinism.<ref name="pmid24446653">{{cite journal| author=Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G et al.| title=European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. | journal=J Clin Endocrinol Metab | year= 2014 | volume= 99 | issue= 2 | pages= 363-84 | pmid=24446653 | doi=10.1210/jc.2013-1891 | pmc=4207909 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24446653  }}</ref>
*Endocrine society recommended with the appropriate quick initiation of [[levothyroxine]] as the mainstay treatment of cretinism.<ref name="pmid24446653">{{cite journal| author=Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G et al.| title=European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. | journal=J Clin Endocrinol Metab | year= 2014 | volume= 99 | issue= 2 | pages= 363-84 | pmid=24446653 | doi=10.1210/jc.2013-1891 | pmc=4207909 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24446653  }}</ref>
*Levothyroxine:  
*'''[[Levothyroxine]]:'''
**Life long synthetic [[levothyroxine]] (L-[[T4]]) is used to treat the cretinism.
**Life long synthetic [[levothyroxine]] (L-[[T4]]) is used to treat the cretinism.
**Dosage:  10–15 μg/kg per day orally  
**Preferred regimen: 10–15 μg/kg per day orally.


==References==
==References==
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[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Up-To-Date]]
[[Category:Pediatrics]]

Latest revision as of 15:04, 30 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

The mainstay of treatment for cretinism is thyroid hormone replacement therapy. levothyroxine (L-T4) is administrated orally to patients with cretinism.

Medical Therapy

  • Patients with cretinism are treated with thyroid hormone replacement therapy.
  • Endocrine society recommended with the appropriate quick initiation of levothyroxine as the mainstay treatment of cretinism.[1]
  • Levothyroxine:
    • Life long synthetic levothyroxine (L-T4) is used to treat the cretinism.
    • Preferred regimen: 10–15 μg/kg per day orally.

References

  1. Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G; et al. (2014). "European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism". J Clin Endocrinol Metab. 99 (2): 363–84. doi:10.1210/jc.2013-1891. PMC 4207909. PMID 24446653.

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