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==Secondary prevention==
==Secondary prevention==
Secondary prevention is preventing further sequelae of already established disease. Regarding coronary heart disease, this can mean risk factor management that is carried out during cardiac rehabilitation, a 4-phase process beginning in hospital after MI, angioplasty or heart surgery and continuing for a minimum of three months. Exercise is a main component of cardiac rehabilitation along with diet, smoking cessation, and blood pressure and cholesterol management.
Secondary prevention is preventing further sequelae of already established disease. Regarding coronary heart disease, this can mean risk factor management that is carried out during cardiac rehabilitation, a 4-phase process beginning in hospital after MI, angioplasty or heart surgery and continuing for a minimum of three months. Exercise is a main component of cardiac rehabilitation along with diet, smoking cessation, and blood pressure and cholesterol management.
==ACE Inhibition==
*Use in all patients with LVEF < 40%, and those with diabetes or chronic kidney disease indefinitely, unless contraindicated
*Consider for all other patients
==Angiotensin Receptor Blockade==
*Use in patients who are intolerant of ACE inhibitors with heart failure or post MI with LVEF less than or equal to 40%.
*Consider in other patients who are ACE inhibitor intolerant.
==Diabetes Mellitus==
*Lifestyle and pharmacotherapy to achieve HbA1C <7% may be considered.
*Less stringent goal for may be considered (severe hypoglycemia, limited life expectancy, extensive comorbidities)


===Anti-platelet therapy===
===Anti-platelet therapy===

Revision as of 05:29, 1 October 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Secondary prevention

Secondary prevention is preventing further sequelae of already established disease. Regarding coronary heart disease, this can mean risk factor management that is carried out during cardiac rehabilitation, a 4-phase process beginning in hospital after MI, angioplasty or heart surgery and continuing for a minimum of three months. Exercise is a main component of cardiac rehabilitation along with diet, smoking cessation, and blood pressure and cholesterol management.

ACE Inhibition

  • Use in all patients with LVEF < 40%, and those with diabetes or chronic kidney disease indefinitely, unless contraindicated
  • Consider for all other patients

Angiotensin Receptor Blockade

  • Use in patients who are intolerant of ACE inhibitors with heart failure or post MI with LVEF less than or equal to 40%.
  • Consider in other patients who are ACE inhibitor intolerant.

Diabetes Mellitus

  • Lifestyle and pharmacotherapy to achieve HbA1C <7% may be considered.
  • Less stringent goal for may be considered (severe hypoglycemia, limited life expectancy, extensive comorbidities)


Anti-platelet therapy

A meta-analysis of randomized controlled trials by the international Cochrane Collaboration found "that the use of clopidogrel plus aspirin is associated with a reduction in the risk of cardiovascular events compared with aspirin alone in patients with acute non-ST coronary syndrome. In patients at high risk of cardiovascular disease but not presenting acutely, there is only weak evidence of benefit and hazards of treatment almost match any benefit obtained.".[1]

References

  1. Keller T, Squizzato A, Middeldorp S (2007). "Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease". Cochrane database of systematic reviews (Online) (3): CD005158. doi:10.1002/14651858.CD005158.pub2. PMID 17636787.