Clopamide: Difference between revisions

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{{drugbox |
{{Drugbox
| verifiedrevid = 447611902
| IUPAC_name = 4-chloro-''N''-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-<br>benzamide
| IUPAC_name = 4-chloro-''N''-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-<br>benzamide
| image = Clopamide.svg
| image = Clopamide.png
| image2 = Clopamide ball-and-stick.png
 
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|clopamide}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK = <!-- GSL        / P      / POM / CD -->
| legal_US = <!-- OTC                  / Rx-only  -->
| legal_status = 
| routes_of_administration = 
 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 636-54-4
| CAS_number = 636-54-4
| ATC_prefix = C03
| ATC_prefix = C03
| ATC_suffix = BA03
| ATC_suffix = BA03
| PubChem = 2804
| PubChem = 2804
| DrugBank =  
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1
| DrugBank =
| ChEMBL = 1361347
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2702
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 17S83WON0I
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D02460
 
<!--Chemical data-->
| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1  
| molecular_weight = 345.846 g/mol
| molecular_weight = 345.846 g/mol
| bioavailability =  
| smiles = O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
| protein_bound =  
| InChI = 1/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)
| metabolism =  
| InChIKey = LBXHRAWDUMTPSE-UHFFFAOYAR
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =  
| StdInChI = 1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)
| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US = <!-- A / B            / C / D / X -->
| StdInChIKey = LBXHRAWDUMTPSE-UHFFFAOYSA-N
| pregnancy_category =
| legal_AU =     <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK =      <!-- GSL        / P      / POM / CD -->
| legal_US =      <!-- OTC                  / Rx-only  -->
| legal_status =  
| routes_of_administration =  
}}
}}
'''Clopamide''' is a [[piperidine]] [[diuretic]].
__NOTOC__
{{SI}}
{{CMG}}


==Overview==
'''Clopamide''' (trade name '''Brinaldix''') is a [[piperidine]] [[diuretic]].<ref>{{cite pmid|3621784}}</ref>


{{drug-stub}}
==Mechanism of Action==
Clopamide is categorised as a [[thiazide-like diuretic]] and works in similar way as the [[thiazide]] diuretics do. It acts in the kidneys, at the [[proximal convoluted tubule]] (PCT) of the [[nephron]] where it inhibits the [[sodium-chloride symporter]]. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of [[sodium chloride]], causing an equi[[osmolar]] excretion of water along with sodium chloride.
 
==References==
{{reflist|2}}


[[pl:Klopamid]]
[[Category:Diuretics]]
[[Category:Diuretics]]
[[Category:Piperidines]]
[[Category:Thiazides]]
 
[[Category:Sulfonamides]]
 
[[Category:Cardiovascular Drugs]]
 
[[Category:Drug]]
Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.

Revision as of 01:08, 25 July 2014

Clopamide
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC14H20ClN3O3S
Molar mass345.846 g/mol
3D model (JSmol)
  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]

Mechanism of Action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References

  1. PMID 3621784 (PMID 3621784)
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