Clopamide

Clopamide

Gene therapy
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C03BA03 (WHO)
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl- benzamide
CAS Number	636-54-4 Y
PubChem Template:Abbreviation	2804
ChemSpider	2702 Y
UNII	17S83WON0I
KEGG	D02460 Y
ChEMBL	ChEMBL1361347 N
Chemical and physical data
Formula	C14H20ClN3O3S
Molar mass	345.846 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
InChI InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) Y Key:LBXHRAWDUMTPSE-UHFFFAOYSA-N Y
(verify)

WikiDoc Resources for Clopamide
Articles
Most recent articles on Clopamide Most cited articles on Clopamide Review articles on Clopamide Articles on Clopamide in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Clopamide Images of Clopamide Photos of Clopamide Podcasts & MP3s on Clopamide Videos on Clopamide
Evidence Based Medicine
Cochrane Collaboration on Clopamide Bandolier on Clopamide TRIP on Clopamide
Clinical Trials
Ongoing Trials on Clopamide at Clinical Trials.gov Trial results on Clopamide Clinical Trials on Clopamide at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Clopamide NICE Guidance on Clopamide NHS PRODIGY Guidance FDA on Clopamide CDC on Clopamide
Books
Books on Clopamide
News
Clopamide in the news Be alerted to news on Clopamide News trends on Clopamide
Commentary
Blogs on Clopamide
Definitions
Definitions of Clopamide
Patient Resources / Community
Patient resources on Clopamide Discussion groups on Clopamide Patient Handouts on Clopamide Directions to Hospitals Treating Clopamide Risk calculators and risk factors for Clopamide
Healthcare Provider Resources
Symptoms of Clopamide Causes & Risk Factors for Clopamide Diagnostic studies for Clopamide Treatment of Clopamide
Continuing Medical Education (CME)
CME Programs on Clopamide
International
Clopamide en Espanol Clopamide en Francais
Business
Clopamide in the Marketplace Patents on Clopamide
Experimental / Informatics
List of terms related to Clopamide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clopamide (trade name Brinaldix) is a piperidine diuretic.

Mechanism of Action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.