Churg-Strauss syndrome (patient information)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Eosinophilic granulomatosis with polyangiitis previously called Churg-Strauss syndrome is a small and medium-sized necrotizing vasculitis, with extravascular granuloma formation. The etiology is not known. However, various environmental factors, allergensgenetics, and drugs may play a role in triggering disease process by activating eosinophilsB and T lymphocytes and macrophages. The disease is characterized by the presence of asthma, peripheral eosinophiliarhinosinusitisperipheral neuropathy and multiple organ involvements including skinGI tract, and kidney.

What are the symptoms of Churg-Strauss syndrome

Symptoms of eosinophilic granulomatosis with polyangiitis typically develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Although these phases cannot be clinically distinguishable.

  • Prodromal phase: Most common manifestations include sinusitis, allergic rhinitis and asthma.
  • Eosinophilic phase: This phase is characterized by peripheral eosinophilia and infiltration of eosinophils in multiple organs. Most commonly involved organs are lung and GI tract.
  • Vasculitic phase:  Symptoms depending on organ system involvement.
    • Weight loss
    • Fatique
    • Skin rash and nodules
    • Numbness and tingling sensation of hands and feet
    • Abdominal pain
    • Diarrhea
    • Nausea and vomiting
    • Shortness of breath (dyspnea) from asthma or congestive heart failure
    • Cough
    • Chest pain
    • Blood in your urine (hematuria)

What causes Churg-Strauss syndrome?

There are no established causes for eosinophilic granulomatosis with polyangiitis. However, various allergensinfectionsvaccinations and drugs may act as a triggering agents, and are responsible for developing disease. Genetics may also play a role.

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