Churg-Strauss syndrome history and symptoms

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Churg-Strauss syndrome Microchapters


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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [3]


Obtaining a complete history is an important aspect in making a diagnosis of eosinophilic granulomatosis with polyangiitis. As it can help differentiate between the ANCA associated vasculitis and other possible causes that may mimic the disease. Symptoms of eosinophilic granulomatosis with polyangiitis develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Clinical presentation depends on organ system involvement. Most common symptoms include asthma, sinusitis, myalgia, arthralgia, purpura, arrythmias, and peripheral neuropathy.

History and Symptoms


  1. Lanham JG, Elkon KB, Pusey CD, Hughes GR (March 1984). "Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome". Medicine (Baltimore). 63 (2): 65–81. PMID 6366453.
  2. 2.0 2.1 Guillevin L, Cohen P, Gayraud M, Lhote F, Jarrousse B, Casassus P (January 1999). "Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients". Medicine (Baltimore). 78 (1): 26–37. PMID 9990352.
  3. Oh MJ, Lee JY, Kwon NH, Choi DC (April 2006). "Churg-Strauss syndrome: the clinical features and long-term follow-up of 17 patients". J. Korean Med. Sci. 21 (2): 265–71. doi:10.3346/jkms.2006.21.2.265. PMC 2734002. PMID 16614512.
  4. Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Ruoppolo G, Altissimi G, De Vincentiis M (April 2015). "Churg-Strauss syndrome". Autoimmun Rev. 14 (4): 341–8. doi:10.1016/j.autrev.2014.12.004. PMID 25500434.
  5. Bacciu A, Bacciu S, Mercante G, Ingegnoli F, Grasselli C, Vaglio A, Pasanisi E, Vincenti V, Garini G, Ronda N, Ferri T, Corradi D, Buzio C (May 2006). "Ear, nose and throat manifestations of Churg-Strauss syndrome". Acta Otolaryngol. 126 (5): 503–9. doi:10.1080/00016480500437435. PMID 16698700.
  6. Yılmaz İ, Tutar N, Şimşek ZÖ, Oymak FS, Gülmez İ (July 2017). "Clinical and Serological Features of Eosinophilic and Vasculitic Phases of Eosinophilic Granulomatosis with Poliangiitis: a Case Series of 15 Patients". Turk Thorac J. 18 (3): 72–77. doi:10.5152/TurkThoracJ.2017.16040. PMC 5783085. PMID 29404165.
  7. Neumann T, Manger B, Schmid M, Kroegel C, Hansch A, Kaiser WA, Reinhardt D, Wolf G, Hein G, Mall G, Schett G, Zwerina J (July 2009). "Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis". Medicine (Baltimore). 88 (4): 236–43. doi:10.1097/MD.0b013e3181af35a5. PMID 19593229.
  8. Marques CC, Fernandes EL, Miquelin GM, Colferai M (2017). "Cutaneous manifestations of Churg-Strauss syndrome: key to diagnosis". An Bras Dermatol. 92 (5 Suppl 1): 56–58. doi:10.1590/abd1806-4841.20175522. PMC 5726678. PMID 29267447. Vancouver style error: initials (help)
  9. Clutterbuck EJ, Evans DJ, Pusey CD (1990). "Renal involvement in Churg-Strauss syndrome". Nephrol. Dial. Transplant. 5 (3): 161–7. PMID 2113641.
  10. Wolf J, Bergner R, Mutallib S, Buggle F, Grau AJ (April 2010). "Neurologic complications of Churg-Strauss syndrome--a prospective monocentric study". Eur. J. Neurol. 17 (4): 582–8. doi:10.1111/j.1468-1331.2009.02902.x. PMID 20050889.