Chronic pancreatitis differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Differentiating Chronic Pancreatitis from Other Diseases
Chronic pancreatitis needs to be differentiated from other diseases with similar presentation such as:
| Disease | History and Symptoms | Physical examination | Laboratory findings | Imaging findings | Gold standard | Other findings | |||
|---|---|---|---|---|---|---|---|---|---|
| Abdominal pain | Steatorrhea | Weight loss | Fever | ||||||
| Chronic pancreatitis | ✔ | ✔ | ✔ | - | DM type II, amylase and lipase levels may be slightly elevated | ||||
| Pancreatic cancer | |||||||||
| Autoimmune pancreatitis | |||||||||
| Lymphoma | |||||||||
| Pancreatic endocrine tumors | |||||||||
| Acute pancreatitis | |||||||||
| Cholangitis | |||||||||
| Biliary obstruction | |||||||||
| Pseudocyst | |||||||||
| Pancreatic duct stricture/stone | |||||||||
| Cholecystitis | |||||||||
| Chronic gastritis | |||||||||
| Community-Acquired Pneumonia (CAP) | |||||||||
| Intestinal perforation | |||||||||
| Crohn disease | |||||||||
| Myocardial infarction | |||||||||
| Mesenteric artery ischemia | |||||||||
| Peptic ulcer disease | |||||||||
| Retroperitoneal hematoma | ✔ | Anemia | MRI is the best radiologic tool to differentiate between retroperitoneal masses. | ||||||
| Retroperitoneal abscess | ✔ | ✔ | Leukocytosis, positive inflammatory markers | ||||||
| Retroperitoneal tumors (.e.g. liposarcoma) | ✔ | ✔ | ✔ | positive tumor marker | |||||