Chronic myelogenous leukemia history and symptoms
Clinical features, when present, are generally nonspecific
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Up to 50% of patients with CML are asymptomatic and clinical features, when present, are generally nonspecific. Common symptoms of CML include fatigue, weight loss, malaise, easy satiety, and left upper quadrant fullness or pain. Less common symptoms of CML include bleeding, thrombosis, gouty arthritis, symptoms of hyperviscosity including priapism, retinal hemorrhages, and upper gastrointestinal ulceration and bleeding. Dyspnea, drowsiness, loss of coordination, and confusion due to sludging in the pulmonary or cerebral vessels, are uncommon symptoms.
PMID:24729196/PMID:26434969
Patients with CML usually appear Splenomegaly. Hepatomegaly is less common. Lymphadenopathy and infiltration of skin or other tissues are uncommon.
Headaches, bone pain, arthralgias, pain from splenic infarction, and fever are more frequent with CML transformation. Most patients evolve into AP prior to BP, but 20% transit into BP without AP warning signals. AP might be insidious or present with worsening anemia, splenomegaly, and organ infiltration; BP presents as an acute leukemia with worsening constitutional symptoms, bleeding, fever, and infections.PMID:24729196
low platelet count and/or platelet dysfunction
thrombocytosis and/or marked leukocytosis
elevated uric acid levels
marked leukocytosis or thrombocytosis
elevated histamine levels due to basophilia