Chronic myelogenous leukemia history and symptoms
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Overview
Common symptoms of chronic myelogenous leukemia may include Fatigue, weight loss, fever, malaise, early satiety and left upper quadrant fullness or pain.
History and symptoms
The history and course of chronic myelogenous leukemia are subtle. The disease is usually detected incidentally in the chronic phase, when an increased white blood cell count is found by a routine blood count or when an enlarged spleen is detected on a general physical examination.[1][2]
History
- Nonspecific symptoms of fatigue and weight loss may occur long after the onset of the disease.
- Loss of energy and decreased exercise tolerance may occur during the chronic phase after several months.
- Patients often have symptoms related to enlargement of the spleen, liver, or both.
- The large spleen may encroach on the stomach and cause early satiety and decreased food intake.
- Left upper quadrant abdominal pain described as "gripping" may occur from spleen infarction.
- The enlarged spleen may also be associated with a hypermetabolic state, fever, weight loss, and chronic fatigue.
- The enlarged liver may cause to the patient's weight loss.
- Some patients with CML have low-grade fever and excessive sweating related to increased metabolism.
Common Symptoms
The most common symptoms of chronic myelogenous leukemia may include:[3][4][5]
- Fatigue
- Weight loss
- Fever
- Malaise
- Early satiety
- Left upper quadrant fullness or pain
Less Common Symptoms
Less common symptoms of chronic myelogenous leukemia may include:[6][7][8]
- Bleeding
- Thrombosis
- Gouty arthritis
- Priapism
- Retinal hemorrhages
- Upper gastrointestinal bleeding and ulceration
Uncommon symptoms of chronic myelogenous leukemia may include:
- Dyspnea
- Drowsiness
- Loss of coordination
- Confusion due to sludging in the pulmonary or cerebral vessels
References
- ↑ Thornton JA, Harrison MJ, Costa E, Kurosawa A, Guidotti A (September 1975). "Letter: Duration of action of AH8165". Br J Anaesth. 47 (9): 1033. PMC 430199. PMID 28.
- ↑ Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM (July 1999). "The biology of chronic myeloid leukemia". N. Engl. J. Med. 341 (3): 164–72. doi:10.1056/NEJM199907153410306. PMID 10403855.
- ↑ Thompson PA, Kantarjian HM, Cortes JE (October 2015). "Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015". Mayo Clin. Proc. 90 (10): 1440–54. doi:10.1016/j.mayocp.2015.08.010. PMC 5656269. PMID 26434969.
- ↑ Jabbour E, Kantarjian H (May 2014). "Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management". Am. J. Hematol. 89 (5): 547–56. doi:10.1002/ajh.23691. PMID 24729196.
- ↑ Thompson PA, Kantarjian HM, Cortes JE (October 2015). "Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015". Mayo Clin. Proc. 90 (10): 1440–54. doi:10.1016/j.mayocp.2015.08.010. PMC 5656269. PMID 26434969.
- ↑ Savage DG, Szydlo RM, Goldman JM (January 1997). "Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period". Br. J. Haematol. 96 (1): 111–6. PMID 9012696.
- ↑ Frazer R, Irvine AE, McMullin MF (January 2007). "Chronic Myeloid Leukaemia in The 21st Century". Ulster Med J. 76 (1): 8–17. PMC 1940291. PMID 17288299.
- ↑ Druker BJ, O'Brien SG, Cortes J, Radich J (2002). "Chronic myelogenous leukemia". Hematology Am Soc Hematol Educ Program: 111–35. PMID 12446421.