Chronic myelogenous leukemia history and symptoms: Difference between revisions
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blood tests. PMID:24729196 | blood tests. PMID:24729196 | ||
Common signs and symptoms of CML in CP, when present, result from anemia and splenomegaly. These include fatigue, weight loss, malaise, easy satiety, and left upper quadrant fullness or pain. Rare manifestations include bleeding (associated with a low platelet count and/or platelet dysfunction), thrombosis (associated with thrombocytosis and/or marked leukocytosis), gouty arthritis (from elevated uric acid levels), priapism (usually with marked leukocytosis or thrombocytosis), retinal hemorrhages, and upper gastrointestinal ulceration and bleeding (from elevated histamine levels due to basophilia). Leukostatic symptoms (dyspnea, drowsiness, loss of coordination, and confusion) due to sludging in the pulmonary or cerebral vessels, are uncommon in CP despite WBC counts exceeding 100 3109/L. Splenomegaly is the most consistent physical sign in CML, and is detected in 50–60% of cases. Hepatomegaly is less common (10–20%).Lymphadenopathy and infiltration of skin or other tissues are uncommon. PMID:24729196 | Common signs and symptoms of CML in CP, when present, result from anemia and splenomegaly. These include fatigue, weight loss, malaise, easy satiety, and left upper quadrant fullness or pain. Rare manifestations include bleeding (associated with a low platelet count and/or platelet dysfunction), thrombosis (associated with thrombocytosis and/or marked leukocytosis), gouty arthritis (from elevated uric acid levels), priapism (usually with marked leukocytosis or thrombocytosis), retinal hemorrhages, and upper gastrointestinal ulceration and bleeding (from elevated histamine levels due to basophilia). Leukostatic symptoms (dyspnea, drowsiness, loss of coordination, and confusion) due to sludging in the pulmonary or cerebral vessels, are uncommon in CP despite WBC counts exceeding 100 3109/L. Splenomegaly is the most consistent physical sign in CML, and is detected in 50–60% of cases. Hepatomegaly is less common (10–20%).Lymphadenopathy and infiltration of skin or other tissues are uncommon. When present, they favor Ph-negative CML or AP or BP of CML. Headaches, bone pain, arthralgias, pain from splenic infarction, and fever are more frequent with CML transformation. Most patients evolve into AP prior to BP, but 20% transit into BP without AP warning signals. AP might be insidious or present with worsening anemia, splenomegaly, and organ infiltration; BP presents as an acute leukemia with worsening constitutional symptoms, bleeding, fever, and infections. | ||
PMID:24729196 | |||
==Symptoms== | ==Symptoms== | ||
Revision as of 15:56, 21 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
About 30 to 50% of patients with CML diagnosed in the United States are asymptomatic. The disease is found on routine physical examination or
blood tests. PMID:24729196
Common signs and symptoms of CML in CP, when present, result from anemia and splenomegaly. These include fatigue, weight loss, malaise, easy satiety, and left upper quadrant fullness or pain. Rare manifestations include bleeding (associated with a low platelet count and/or platelet dysfunction), thrombosis (associated with thrombocytosis and/or marked leukocytosis), gouty arthritis (from elevated uric acid levels), priapism (usually with marked leukocytosis or thrombocytosis), retinal hemorrhages, and upper gastrointestinal ulceration and bleeding (from elevated histamine levels due to basophilia). Leukostatic symptoms (dyspnea, drowsiness, loss of coordination, and confusion) due to sludging in the pulmonary or cerebral vessels, are uncommon in CP despite WBC counts exceeding 100 3109/L. Splenomegaly is the most consistent physical sign in CML, and is detected in 50–60% of cases. Hepatomegaly is less common (10–20%).Lymphadenopathy and infiltration of skin or other tissues are uncommon. When present, they favor Ph-negative CML or AP or BP of CML. Headaches, bone pain, arthralgias, pain from splenic infarction, and fever are more frequent with CML transformation. Most patients evolve into AP prior to BP, but 20% transit into BP without AP warning signals. AP might be insidious or present with worsening anemia, splenomegaly, and organ infiltration; BP presents as an acute leukemia with worsening constitutional symptoms, bleeding, fever, and infections.
PMID:24729196