Cholangiocarcinoma epidemiology and demographics: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
(Mahshid)
 
(28 intermediate revisions by one other user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Cholangiocarcinoma}}
{{Cholangiocarcinoma}}
{{CMG}};{{AE}} {{PSK}}
 
{{CMG}}; {{AE}}{{F.K}} [mailto:fkahe@bidmc.harvard.edu], {{PSK}}  
==Overview==
==Overview==
Cholangiocarcinoma is a rare disease and it is the second most common type of primary hepatic tumor. The overall [[incidence]] of cholangiocarcinoma in the U.S. population is estimated at 1-2 cases per 100,000 individuals.<ref>{{cite journal |author=Vauthey J, Blumgart L |title=Recent advances in the management of cholangiocarcinomas |journal=Semin Liver Dis |volume=14 |issue=2 |pages=109-14 |year=1994 |id=PMID 8047893}}</ref> The prevalence of cholangiocarcinoma is approximately 0.01% to 0.46% per 100,000 individuals.<ref>{{cite journal |author=Vauthey J, Blumgart L |title=Recent advances in the management of cholangiocarcinomas |journal=Semin Liver Dis |volume=14 |issue=2 |pages=109-14 |year=1994 |id=PMID 8047893}}</ref> The [[prevalence]] of cholangiocarcinoma in patients with [[primary sclerosing cholangitis]] may be as high as 30%, based on autopsy studies.<ref name="autopsy">{{cite journal |author=Rosen C, Nagorney D, Wiesner R, Coffey R, LaRusso N |title=Cholangiocarcinoma complicating primary sclerosing cholangitis |journal=Ann Surg |volume=213 |issue=1 |pages=21-5 |year=1991 |id=PMID 1845927}}</ref> [[Mortality]] of cholangiocarcinoma is slightly higher in men (1.9/100.000) than in women (1.5/100.000).<ref name="Macias2014">{{cite journal|last1=Macias|first1=Rocio I. R.|title=Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives|journal=ISRN Hepatology|volume=2014|year=2014|pages=1–13|issn=2314-4041|doi=10.1155/2014/828074}}</ref> The average age of the patients at the time of cholangiocarcinoma diagnosis is 70-80 years, except in patients with bile duct cystic disorders, which usually develop cholangiocarcinoma much earlier, between 30 and 40 years.<ref name="Macias2014">{{cite journal|last1=Macias|first1=Rocio I. R.|title=Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives|journal=ISRN Hepatology|volume=2014|year=2014|pages=1–13|issn=2314-4041|doi=10.1155/2014/828074}}</ref>
The [[incidence]] of cholangiocarcinoma is approximately 1-2 per 100,000 individuals in the United States. The [[prevalence]] of cholangiocarcinoma is approximately 0.01% to 0.46% per 100,000 individuals. Patients of all age groups may develop cholangiocarcinoma. Cholangiocarcinoma is more common in males than in females.


==Epidemiology==
==Epidemiology and Demographics==
*Cholangiocarcinoma is the second most common type of primary [[hepatic tumor]], with intrahepatic cholangiocarcinomas (ICCs) accounting for 10-20% of primary liver tumors.
===Incidence===
*The [[incidence]] of cholangiocarcinoma is approximately 1-2 per 100,000 individuals in the United States.
*The highest annual incidences of cholangiocarcinoma is 5.5 cases per 100,000 people in Japan, and 7.3 cases per 100,000 people in Israel.<ref name="pmid18773060">{{cite journal |vauthors=Khan SA, Toledano MB, Taylor-Robinson SD |title=Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma |journal=HPB (Oxford) |volume=10 |issue=2 |pages=77–82 |year=2008 |pmid=18773060 |pmc=2504381 |doi=10.1080/13651820801992641 |url=}}</ref>


==Incidence==
===Prevalence===
*Cholangiocarcinoma is a rare disease.
*The [[prevalence]] of cholangiocarcinoma is approximately 0.01% to 0.46% per 100,000 individuals.
*There are significant variations in incidence according to region, with much higher rates seen in southeast Asia.
*The [[prevalence]] of cholangiocarcinoma in patients with [[primary sclerosing cholangitis]] may be as high as 30%, based on [[autopsy]] studies.<ref name="pmid18773060">{{cite journal |vauthors=Khan SA, Toledano MB, Taylor-Robinson SD |title=Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma |journal=HPB (Oxford) |volume=10 |issue=2 |pages=77–82 |year=2008 |pmid=18773060 |pmc=2504381 |doi=10.1080/13651820801992641 |url=}}</ref><ref name="pmid25966423">{{cite journal |vauthors=Bergquist A, von Seth E |title=Epidemiology of cholangiocarcinoma |journal=Best Pract Res Clin Gastroenterol |volume=29 |issue=2 |pages=221–32 |year=2015 |pmid=25966423 |doi=10.1016/j.bpg.2015.02.003 |url=}}</ref>
*The overall incidence of cholangiocarcinoma in U.S. population is estimated at 1-2 cases per 100,000 individuals.<ref>{{cite journal |author=Vauthey J, Blumgart L |title=Recent advances in the management of cholangiocarcinomas |journal=Semin Liver Dis |volume=14 |issue=2 |pages=109-14 |year=1994 |id=PMID 8047893}}</ref>
*Multiple studies have documented a steady increase in the incidence of intrahepatic cholangiocarcinoma over the past several decades. Increases have been observed in North America, Europe, Asia, and Australia.<ref>Multiple independent studies have documented a steady increase in the worldwide incidence of cholangiocarcinoma. Some relevant journal articles include:
*{{cite journal |author=Patel T |title=Worldwide trends in mortality from biliary tract malignancies |journal=BMC Cancer |volume=2 |issue= |pages=10 |year= |id=PMID 11991810}}
*{{cite journal |author=Patel T |title=Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States |journal=Hepatology |volume=33 |issue=6 |pages=1353–7 |year=2001 |id=PMID 11391522}}
*{{cite journal |author=Shaib Y, Davila J, McGlynn K, El-Serag H |title=Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase? |journal=J Hepatol |volume=40 |issue=3 |pages=472-7 |year=2004 |id=PMID 15123362}}
*{{cite journal |author=West J, Wood H, Logan R, Quinn M, Aithal G |title=Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971–2001 |journal=Br J Cancer |volume=94 |issue=11 |pages=1751–8 |year=2006 |id=PMID 16736026}}
*{{cite journal |author=Khan S, Taylor-Robinson S, Toledano M, Beck A, Elliott P, Thomas H |title=Changing international trends in mortality rates for liver, biliary and pancreatic tumours |journal=J Hepatol |volume=37 |issue=6 |pages=806-13 |year=2002 |id=PMID 12445422}}
*{{cite journal |author=Welzel T, McGlynn K, Hsing A, O'Brien T, Pfeiffer R |title=Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States |journal=J Natl Cancer Inst |volume=98 |issue=12 |pages=873-5 |year=2006 |id=PMID 16788161}}</ref> The reasons for the increasing occurrence of cholangiocarcinoma are unclear; improved diagnostic methods may be partially responsible, but the prevalence of potential risk factors for cholangiocarcinoma, such as [[HIV|HIV infection]], has also been increasing during this time frame.<ref name="riskfactors">{{cite journal |author=Shaib Y, El-Serag H, Davila J, Morgan R, McGlynn K |title=Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study |journal=Gastroenterology |volume=128 |issue=3 |pages=620-6 |year=2005 |id=PMID 15765398}}</ref>


==Prevalence==
===Case-fatality rate/Mortality rate===
*The prevalence of cholangiocarcinoma is approximately 0.01% to 0.46% per 100,000 individuals.<ref>{{cite journal |author=Vauthey J, Blumgart L |title=Recent advances in the management of cholangiocarcinomas |journal=Semin Liver Dis |volume=14 |issue=2 |pages=109-14 |year=1994 |id=PMID 8047893}}</ref>
*The mortality rate for [[intrahepatic cholangiocarcinoma]] among men increased from 0.17 to 0.78 per 100,000 in period of 1975-1979 to 1993-1997.<ref name="pmid17457168">{{cite journal |vauthors=DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD |title=Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution |journal=Ann. Surg. |volume=245 |issue=5 |pages=755–62 |year=2007 |pmid=17457168 |pmc=1877058 |doi=10.1097/01.sla.0000251366.62632.d3 |url=}}</ref>
*In the United States, the highest prevalence adjusted by age is found in the Hispanic population, whereas the lowest is found in African Americans.<ref name="Macias2014">{{cite journal|last1=Macias|first1=Rocio I. R.|title=Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives|journal=ISRN Hepatology|volume=2014|year=2014|pages=1–13|issn=2314-4041|doi=10.1155/2014/828074}}</ref>
*The mortality rate for [[intrahepatic cholangiocarcinoma]] among women, increased from 0.12 to 0.57 per 100,000 in period of 1975-1979 to 1993-1997.
*There is a higher prevalence of cholangiocarcinoma in Asia, which has been attributed to endemic chronic parasitic infestation.
*The prevalence of cholangiocarcinoma in patients with primary sclerosing cholangitis may be as high as 30%, based on autopsy studies.<ref name="autopsy">{{cite journal |author=Rosen C, Nagorney D, Wiesner R, Coffey R, LaRusso N |title=Cholangiocarcinoma complicating primary sclerosing cholangitis |journal=Ann Surg |volume=213 |issue=1 |pages=21-5 |year=1991 |id=PMID 1845927}}</ref>


==Mortality==
===Age===
*Mortality of cholangiocarcinoma is slightly higher in men (1.9/100.000) than in women (1.5/100.000).<ref name="Macias2014">{{cite journal|last1=Macias|first1=Rocio I. R.|title=Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives|journal=ISRN Hepatology|volume=2014|year=2014|pages=1–13|issn=2314-4041|doi=10.1155/2014/828074}}</ref> [[Age Standardized Mortality Rates|Age-standardized mortality rates]] from intrahepatic (IC) and extrahepatic (EC) cholangiocarcinoma for men and women, by country are illustrated in the following table:
*Patients of all age groups may develop cholangiocarcinoma.
{| style="width: 50%; border-collapse: collapse; margin: 0.2em;" border="2" align="left"
*The median age at the time of cholangiocarcinoma diagnosis is 70-80 years, except in patients with [[bile duct]] cystic disorders.<ref name="Macias2014">{{cite journal|last1=Macias|first1=Rocio I. R.|title=Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives|journal=ISRN Hepatology|volume=2014|year=2014|pages=1–13|issn=2314-4041|doi=10.1155/2014/828074}}</ref>
|+ align="bottom" | ''[[Age Standardized Mortality Rates|Age-standardized mortality rates]] from intrahepatic (IC) and extrahepatic (EC) cholangiocarcinoma for men and women, by country. Source: Khan et al, 2002.<ref>{{cite journal |author=Khan S, Taylor-Robinson S, Toledano M, Beck A, Elliott P, Thomas H |title=Changing international trends in mortality rates for liver, biliary and pancreatic tumours |journal=J Hepatol |volume=37 |issue=6 |pages=806-13 |year=2002 |pmid=12445422}}</ref>''
*[[Bile duct]] cystic disorders usually develop cholangiocarcinoma much earlier, between 30 and 40 years.
|-
! ''Country''
! ''IC (men/women)''
! ''EC (men/women)''
|-
! U.S.A.
| align="center" | 0.60 / 0.43
| align="center" | 0.70 / 0.87
|-
! Japan
| align="center" | 0.23 / 0.10
| align="center" | 5.87 / 5.20
|-
! Australia
| align="center" | 0.70 / 0.53
| align="center" | 0.90 / 1.23
|-
! England/Wales
| align="center" | 0.83 / 0.63
| align="center" | 0.43 / 0.60
|-
! Scotland
| align="center" | 1.17 / 1.00
| align="center" | 0.60 / 0.73
|-
! France
| align="center" | 0.27 / 0.20
| align="center" | 1.20 / 1.37
|-
! Italy
| align="center" | 0.13 / 0.13
| align="center" | 2.10 / 2.60
|}


<br clear="left"/>
===Race===
*Cholangiocarcinoma usually affects individuals of the American Indian, Alaska Natives and Asian and Pacific Islanders race.<ref name="pmid17032404">{{cite journal |vauthors=McLean L, Patel T |title=Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States |journal=Liver Int. |volume=26 |issue=9 |pages=1047–53 |year=2006 |pmid=17032404 |doi=10.1111/j.1478-3231.2006.01350.x |url=}}</ref>


==Gender==
===Gender===
*Cholangiocarcinoma is more common in males than in females (possibly due to the higher rate of [[primary sclerosing cholangitis]], a major risk factor, in men).<ref name=radio>Cholangiocarcinoma. Radiopaedia. http://radiopaedia.org/articles/cholangiocarcinoma</ref>
*Cholangiocarcinoma is more common in males than in females.<ref name="radio">Cholangiocarcinoma. Radiopaedia. http://radiopaedia.org/articles/cholangiocarcinoma</ref>


==Age==
===Region===
*Patients of all age groups may develop cholangiocarcinoma.
*The majority of cholangiocarcinoma cases are reported in North America, Asia, and Australia.<ref name="pmid17032404">{{cite journal |vauthors=McLean L, Patel T |title=Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States |journal=Liver Int. |volume=26 |issue=9 |pages=1047–53 |year=2006 |pmid=17032404 |doi=10.1111/j.1478-3231.2006.01350.x |url=}}</ref>
*The average age of the patients at the time of cholangiocarcinoma diagnosis is 70-80 years, except in patients with bile duct cystic disorders, which usually develop cholangiocarcinoma much earlier, between 30 and 40 years.<ref name="Macias2014">{{cite journal|last1=Macias|first1=Rocio I. R.|title=Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives|journal=ISRN Hepatology|volume=2014|year=2014|pages=1–13|issn=2314-4041|doi=10.1155/2014/828074}}</ref>
*The incidence of cholangiocarcinoma increases with age.<ref>{{cite journal |author=Henson D, Albores-Saavedra J, Corle D |title=Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, grade, and survival rates |journal=Cancer |volume=70 |issue=6 |pages=1498-501 |year=1992 |id=PMID 1516001}}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
 
[[Category:Disease]]
[[Category:Rare cancers]]
[[Category:Rare diseases]]
[[Category:Types of cancer]]
[[Category:Hepatology]]
[[Category:Gastroenterology]]


{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Up-To-Date]]
[[Category: (name of the system)]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Surgery]]

Latest revision as of 15:17, 12 February 2018

Cholangiocarcinoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cholangiocarcinoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cholangiocarcinoma epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Cholangiocarcinoma epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cholangiocarcinoma epidemiology and demographics

CDC on Cholangiocarcinoma epidemiology and demographics

Cholangiocarcinoma epidemiology and demographics in the news

Blogs on Cholangiocarcinoma epidemiology and demographics

Directions to Hospitals Treating Cholangiocarcinoma

Risk calculators and risk factors for Cholangiocarcinoma epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] [3], Suveenkrishna Pothuru, M.B,B.S. [4]

Overview

The incidence of cholangiocarcinoma is approximately 1-2 per 100,000 individuals in the United States. The prevalence of cholangiocarcinoma is approximately 0.01% to 0.46% per 100,000 individuals. Patients of all age groups may develop cholangiocarcinoma. Cholangiocarcinoma is more common in males than in females.

Epidemiology and Demographics

Incidence

  • The incidence of cholangiocarcinoma is approximately 1-2 per 100,000 individuals in the United States.
  • The highest annual incidences of cholangiocarcinoma is 5.5 cases per 100,000 people in Japan, and 7.3 cases per 100,000 people in Israel.[1]

Prevalence

Case-fatality rate/Mortality rate

Age

  • Patients of all age groups may develop cholangiocarcinoma.
  • The median age at the time of cholangiocarcinoma diagnosis is 70-80 years, except in patients with bile duct cystic disorders.[4]
  • Bile duct cystic disorders usually develop cholangiocarcinoma much earlier, between 30 and 40 years.

Race

  • Cholangiocarcinoma usually affects individuals of the American Indian, Alaska Natives and Asian and Pacific Islanders race.[5]

Gender

  • Cholangiocarcinoma is more common in males than in females.[6]

Region

  • The majority of cholangiocarcinoma cases are reported in North America, Asia, and Australia.[5]

References

  1. ↑ 1.0 1.1 Khan SA, Toledano MB, Taylor-Robinson SD (2008). "Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma". HPB (Oxford). 10 (2): 77–82. doi:10.1080/13651820801992641. PMC 2504381. PMID 18773060.
  2. ↑ Bergquist A, von Seth E (2015). "Epidemiology of cholangiocarcinoma". Best Pract Res Clin Gastroenterol. 29 (2): 221–32. doi:10.1016/j.bpg.2015.02.003. PMID 25966423.
  3. ↑ DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). "Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution". Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.
  4. ↑ Macias, Rocio I. R. (2014). "Cholangiocarcinoma: Biology, Clinical Management, and Pharmacological Perspectives". ISRN Hepatology. 2014: 1–13. doi:10.1155/2014/828074. ISSN 2314-4041.
  5. ↑ 5.0 5.1 McLean L, Patel T (2006). "Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States". Liver Int. 26 (9): 1047–53. doi:10.1111/j.1478-3231.2006.01350.x. PMID 17032404.
  6. ↑ Cholangiocarcinoma. Radiopaedia. http://radiopaedia.org/articles/cholangiocarcinoma

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Cholangiocarcinoma_epidemiology_and_demographics&oldid=1443684"