Chemical colitis: Difference between revisions

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===Pathogenesis===
===Pathogenesis===
Chemical colitis usually results from accidental or intentional rectal introduction of chemicals such as endoscopy cleaning solutions (glutaraldehyde and hydrogen peroxide), radiologic contrast material, hydrogen peroxide, soaps, formalin, hydrofluoric acid, alcohol, ammonia, lye, hot water, and herbal substances.<ref name="pmid23208963">{{cite journal| author=Tortora A, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G et al.| title=Colitides. | journal=Eur Rev Med Pharmacol Sci | year= 2012 | volume= 16 | issue= 13 | pages= 1795-805 | pmid=23208963 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23208963  }} </ref><ref name="pmid18209577">{{cite journal| author=Sheibani S, Gerson LB| title=Chemical colitis. | journal=J Clin Gastroenterol | year= 2008 | volume= 42 | issue= 2 | pages= 115-21 | pmid=18209577 | doi=10.1097/MCG.0b013e318151470e | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18209577  }} </ref><ref name="pmid21873825">{{cite journal| author=Lim CH, Lee HY, Kim WC, Cho SH, Jeong HS, Jeon YJ et al.| title=[A case of chemical colitis caused by hydrogen peroxide enema]. | journal=Korean J Gastroenterol | year= 2011 | volume= 58 | issue= 2 | pages= 100-2 | pmid=21873825 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21873825  }} </ref><ref name="pmid7698592">{{cite journal| author=West AB, Kuan SF, Bennick M, Lagarde S| title=Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak. | journal=Gastroenterology | year= 1995 | volume= 108 | issue= 4 | pages= 1250-5 | pmid=7698592 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7698592  }} </ref><ref name="pmid22208542">{{cite journal| author=Shih HY, Wu DC, Huang WT, Chang YY, Yu FJ| title=Glutaraldehyde-induced colitis: case reports and literature review. | journal=Kaohsiung J Med Sci | year= 2011 | volume= 27 | issue= 12 | pages= 577-80 | pmid=22208542 | doi=10.1016/j.kjms.2011.06.036 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22208542  }} </ref>
Chemical colitis usually results from accidental or intentional rectal introduction of chemicals such as endoscopy cleaning solutions (glutaraldehyde and hydrogen peroxide), radiologic contrast material, hydrogen peroxide, soaps, formalin, hydrofluoric acid, alcohol, ammonia, lye, hot water, and herbal substances.<ref name="pmid23208963">{{cite journal| author=Tortora A, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G et al.| title=Colitides. | journal=Eur Rev Med Pharmacol Sci | year= 2012 | volume= 16 | issue= 13 | pages= 1795-805 | pmid=23208963 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23208963  }} </ref><ref name="pmid18209577">{{cite journal| author=Sheibani S, Gerson LB| title=Chemical colitis. | journal=J Clin Gastroenterol | year= 2008 | volume= 42 | issue= 2 | pages= 115-21 | pmid=18209577 | doi=10.1097/MCG.0b013e318151470e | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18209577  }} </ref><ref name="pmid21873825">{{cite journal| author=Lim CH, Lee HY, Kim WC, Cho SH, Jeong HS, Jeon YJ et al.| title=[A case of chemical colitis caused by hydrogen peroxide enema]. | journal=Korean J Gastroenterol | year= 2011 | volume= 58 | issue= 2 | pages= 100-2 | pmid=21873825 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21873825  }} </ref><ref name="pmid7698592">{{cite journal| author=West AB, Kuan SF, Bennick M, Lagarde S| title=Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak. | journal=Gastroenterology | year= 1995 | volume= 108 | issue= 4 | pages= 1250-5 | pmid=7698592 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7698592  }} </ref><ref name="pmid22208542">{{cite journal| author=Shih HY, Wu DC, Huang WT, Chang YY, Yu FJ| title=Glutaraldehyde-induced colitis: case reports and literature review. | journal=Kaohsiung J Med Sci | year= 2011 | volume= 27 | issue= 12 | pages= 577-80 | pmid=22208542 | doi=10.1016/j.kjms.2011.06.036 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22208542  }} </ref>
*It occasionally results from accidental oral introduction of chemicals, such as accidental swallowing of hydrogen peroxide mouthwash  
*It rarely results from accidental ingestion of chemicals, such as accidental swallowing of hydrogen peroxide mouthwash during oral procedures.
*Direct mucosa contact with the chemical agent results in colitis.
*The most common implicated chemical agents in the pathogenesis of chemical colitis are glutaraldehyde and/or hydrogen peroxide disinfectants. The improper cleaning of the endoscopes allows the disinfectants to remain on the endoscopes, subsequently causing a chemical proctocolitis when the endoscopes are used.
*Improper cleaning of the endoscopes allows the glutaraldehyde disinfectant to remain on the endoscopes, subsequently causing a chemical proctocolitis when the endoscopes are used.  
*The main mechanism for developing chemical colitis is the direct contact of the chemical agent with the mucosa with subsequent corrosive injury to the mucosa. Reactive oxygen formation, lipid peroxidation and vascular smooth muscle contraction also occur in hydrogen peroxide-induced chemical colitis.
*The primary mucosa toxin in glutaraldehyde is not fully known. However, it may be related to the aldehyde.<ref name="pmid7698592">{{cite journal| author=West AB, Kuan SF, Bennick M, Lagarde S| title=Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak. | journal=Gastroenterology | year= 1995 | volume= 108 | issue= 4 | pages= 1250-5 | pmid=7698592 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7698592  }} </ref>
*The primary mucosa toxin in glutaraldehyde is not fully known. However, it may be related to the aldehyde.<ref name="pmid7698592">{{cite journal| author=West AB, Kuan SF, Bennick M, Lagarde S| title=Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak. | journal=Gastroenterology | year= 1995 | volume= 108 | issue= 4 | pages= 1250-5 | pmid=7698592 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7698592  }} </ref>
 
*The symptoms of chemical colitis usually develop within 12 to 48 hours after introduction of the chemical, but may sometimes take days to weeks in case of small dilute contact
===Genetics===
===Genetics===



Revision as of 17:50, 5 December 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Qasim Salau, M.B.B.S., FMCPaed [3]

Synonyms and keywords: Disinfectant colitis, Corrosive colitis, Iatrogenic colitis.

Overview

Chemical colitis is a type of colitis, an inflammation of the large intestine or colon, caused by the introduction of harsh chemicals to the colon by an enema or other procedure. Chemical colitis can resemble ulcerative colitis, infectious colitis and pseudomembranous colitis endoscopically.

Prior to 1950, hydrogen peroxide enemas were commonly used for certain conditions. This practice will often result in chemical colitis.

Soap enemas may also cause chemical colitis. [1] Harsh chemicals, such as compounds used to clean colonoscopes, are sometimes accidentally introduced into the colon during colonoscopy or other procedures. This can also lead to chemical colitis.

Chemical colitis may trigger a flare of ulcerative colitis or Crohn's disease.

Historical Perspective

Classification

Pathophysiology

Pathogenesis

Chemical colitis usually results from accidental or intentional rectal introduction of chemicals such as endoscopy cleaning solutions (glutaraldehyde and hydrogen peroxide), radiologic contrast material, hydrogen peroxide, soaps, formalin, hydrofluoric acid, alcohol, ammonia, lye, hot water, and herbal substances.[2][3][4][5][6]

  • It rarely results from accidental ingestion of chemicals, such as accidental swallowing of hydrogen peroxide mouthwash during oral procedures.
  • The most common implicated chemical agents in the pathogenesis of chemical colitis are glutaraldehyde and/or hydrogen peroxide disinfectants. The improper cleaning of the endoscopes allows the disinfectants to remain on the endoscopes, subsequently causing a chemical proctocolitis when the endoscopes are used.
  • The main mechanism for developing chemical colitis is the direct contact of the chemical agent with the mucosa with subsequent corrosive injury to the mucosa. Reactive oxygen formation, lipid peroxidation and vascular smooth muscle contraction also occur in hydrogen peroxide-induced chemical colitis.
  • The primary mucosa toxin in glutaraldehyde is not fully known. However, it may be related to the aldehyde.[5]
  • The symptoms of chemical colitis usually develop within 12 to 48 hours after introduction of the chemical, but may sometimes take days to weeks in case of small dilute contact

Genetics

Gross Pathology

Microscopic Histopathology

Differentiating chemical colitis from other Diseases

Epidemiology and Demographics

Age

Gender

Race

Risk Factors

Screening

There are no established screening guidelines for chemical colitis[7]

Natural History, Complications and Prognosis

Natural History

Complications

Prognosis

Diagnosis

Diagnostic Criteria

Symptoms

Physical Examination

Laboratory Findings

Endoscopy

Other Diagnostic Studies

Barium enema

CT scan

Treatment

Medical Therapy

Surgical Therapy

Prevention

Primary prevention

Secondary prevention

References

  1. K. Harish, Severe colitis induced by soap enemas, Indian J. Gastroent., 2006 [1]
  2. Tortora A, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G; et al. (2012). "Colitides". Eur Rev Med Pharmacol Sci. 16 (13): 1795–805. PMID 23208963.
  3. Sheibani S, Gerson LB (2008). "Chemical colitis". J Clin Gastroenterol. 42 (2): 115–21. doi:10.1097/MCG.0b013e318151470e. PMID 18209577.
  4. Lim CH, Lee HY, Kim WC, Cho SH, Jeong HS, Jeon YJ; et al. (2011). "[A case of chemical colitis caused by hydrogen peroxide enema]". Korean J Gastroenterol. 58 (2): 100–2. PMID 21873825.
  5. 5.0 5.1 West AB, Kuan SF, Bennick M, Lagarde S (1995). "Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak". Gastroenterology. 108 (4): 1250–5. PMID 7698592.
  6. Shih HY, Wu DC, Huang WT, Chang YY, Yu FJ (2011). "Glutaraldehyde-induced colitis: case reports and literature review". Kaohsiung J Med Sci. 27 (12): 577–80. doi:10.1016/j.kjms.2011.06.036. PMID 22208542.
  7. US preventive service task force.chemical colitis. http://www.uspreventiveservicestaskforce.org/accessed on December 5, 2016

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