Caroverine: Difference between revisions
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==Overview== | ==Overview== | ||
'''Caroverine''' ('''Spasmium''', '''Spadon''', '''Tinnex''') is a [[drug]] used as a [[muscle relaxant#Spasmolytics|spasmolytic]] and ''otoneuroprotective'' ([[inner ear]] [[neuroprotection|protective]]) agent in some countries.<ref name=pmid12473379>{{ cite journal | author = Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H | title = The Antioxidant Activity of Caroverine | journal = [[Biochemical Pharmacology]] | year = 2003 | volume = 65 | issue = 1 | pages = 59–65 | pmid = 12473379 | doi = 10.1016/S0006-2952(02)01452-1 }}</ref> It acts as an [[N-type calcium channel]] [[calcium channel blocker|blocker]], [[competitive inhibition|competitive]] [[AMPA receptor#Antagonists|AMPA receptor antagonist]], and [[non-competitive inhibition|non-competitive]] [[NMDA receptor antagonist]].<ref name=pmid12473379/> It also has potent [[antioxidant]] effects.<ref name=pmid12473379/><ref name=pmid14757980>{{ cite journal | author = Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV | title = Caroverine, a Multifunctional Drug with Antioxidant Functions | journal = BioFactors | year = 2003 | volume = 19 | issue = 1–2 | pages = 79–85 | pmid = 14757980 | doi = 10.1002/biof.5520190110 }}</ref> | '''Caroverine''' ('''Spasmium''', '''Spadon''', '''Tinnex''') is a [[drug]] used as a [[muscle relaxant#Spasmolytics|spasmolytic]] and ''otoneuroprotective'' ([[inner ear]] [[neuroprotection|protective]]) agent in some countries.<ref name=pmid12473379>{{ cite journal | author = Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H | title = The Antioxidant Activity of Caroverine | journal = [[Biochemical Pharmacology]] | year = 2003 | volume = 65 | issue = 1 | pages = 59–65 | pmid = 12473379 | doi = 10.1016/S0006-2952(02)01452-1 }}</ref> It acts as an [[N-type calcium channel]] [[calcium channel blocker|blocker]], [[competitive inhibition|competitive]] [[AMPA receptor#Antagonists|AMPA receptor antagonist]], and [[non-competitive inhibition|non-competitive]] [[NMDA receptor antagonist]].<ref name=pmid12473379/> It also has potent [[antioxidant]] effects.<ref name=pmid12473379/><ref name=pmid14757980>{{ cite journal | author = Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV | title = Caroverine, a Multifunctional Drug with Antioxidant Functions | journal = BioFactors | year = 2003 | volume = 19 | issue = 1–2 | pages = 79–85 | pmid = 14757980 | doi = 10.1002/biof.5520190110 }}</ref> | ||
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==Applications== | ==Applications== | ||
Caroverine has been demonstrated to have a high rate of efficacy in the treatment of cochlear-synaptic tinnitus.<ref>{{cite journal |title=Caroverine in tinnitus treatment. A placebo-controlled blind study. |author=Denk DM, Heinzl H, Franz P, Ehrenberger K. |date=Nov 1997 |journal=Acta Oto-Laryngologica |PMID=9442821}}</ref> | Caroverine has been demonstrated to have a high rate of efficacy in the treatment of cochlear-synaptic tinnitus.<ref>{{cite journal |title=Caroverine in tinnitus treatment. A placebo-controlled blind study. |author=Denk DM, Heinzl H, Franz P, Ehrenberger K. |date=Nov 1997 |journal=Acta Oto-Laryngologica |PMID=9442821}}</ref> | ||
==References== | ==References== | ||
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{{Muscle relaxants}} | {{Muscle relaxants}} | ||
{{Calcium channel blockers}} | {{Calcium channel blockers}} | ||
[[Category:Quinoxalines]] | [[Category:Quinoxalines]] | ||
[[Category:Lactams]] | [[Category:Lactams]] | ||
[[Category:Phenol ethers]] | [[Category:Phenol ethers]] | ||
[[Category:NMDA receptor antagonists]] | [[Category:NMDA receptor antagonists]] | ||
[[Category:Drug]] | [[Category:Drug]] |
Revision as of 18:13, 9 April 2015
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Routes of administration | Oral |
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E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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Formula | C22H27N3O2 |
Molar mass | 365.47 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Caroverine (Spasmium, Spadon, Tinnex) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]
Applications
Caroverine has been demonstrated to have a high rate of efficacy in the treatment of cochlear-synaptic tinnitus.[3]
References
- ↑ 1.0 1.1 1.2 Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (2003). "The Antioxidant Activity of Caroverine". Biochemical Pharmacology. 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379.
- ↑ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a Multifunctional Drug with Antioxidant Functions". BioFactors. 19 (1–2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980.
- ↑ Denk DM, Heinzl H, Franz P, Ehrenberger K. (Nov 1997). "Caroverine in tinnitus treatment. A placebo-controlled blind study". Acta Oto-Laryngologica. PMID 9442821.
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