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{{Cardiogenic shock}}
{{Cardiogenic shock}}
{{CMG}}; {{AE}} {{AZ}} {{JS}}
{{CMG}}; {{AE}} {{AZ}}; {{JS}}; {{Rim}} {{sali}}


==Overview==
==Overview==
Attending to the catastrophic [[outcome]] of cardiogenic shock in a very short time span, its [[diagnosis]] must be reached as early as possible in order for proper [[therapy]] to be started. This period until [[diagnosis]] and treatment initiation is particularly important in the case of cardiogenic shock since the [[mortality rate]] of this condition, complicating acute-[[MI]], is very high, as well as, the ability to revert the damage by [[reperfusion]] techniques declines considerably with [[diagnostic]] delays. Therefore and due to the unstable state of these patients, the [[diagnostic]] evaluations are usually performed as supportive measures are initiated. The [[diagnostic]] measures should start with the proper history and [[physical examination]], including [[blood pressure]] beasurements, followed by an [[EKG]], [[chest x-ray]] and collection of [[blood]] samples for evaluation. The physician should have in mind the common features of [[shock]], irrespective of the type of [[shock]], in order to avoid delays in the [[diagnosis]]. Although not all [[shock]] patients present in the same way, these features include: abnormal [[mental status]], [[cool extremities]], [[clammy skin]], manifestations of [[hypoperfusion]], such as [[hypotension]], [[oliguria]] and evidence of [[metabolic acidosis]] on the [[blood]] results.
Cardiogenic shock is the presence of tissue hypoperfusion secondary to decreased [[cardiac output]] in the context of adequate intravascular volume.
 
==Diagnostic Evaluation==
 
* In clinical trials, particularly the ''SHOCK trial'', cardiogenic shock in patients with [[acute myocardial infarction]] has been defined as:<ref name="Hochman-1999">{{Cite journal  | last1 = Hochman | first1 = JS. | last2 = Sleeper | first2 = LA. | last3 = Webb | first3 = JG. | last4 = Sanborn | first4 = TA. | last5 = White | first5 = HD. | last6 = Talley | first6 = JD. | last7 = Buller | first7 = CE. | last8 = Jacobs | first8 = AK. | last9 = Slater | first9 = JN. | title = Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. | journal = N Engl J Med | volume = 341 | issue = 9 | pages = 625-34 | month = Aug | year = 1999 | doi = 10.1056/NEJM199908263410901 | PMID = 10460813 }}</ref>
 
:* Presence of [[ST-segment elevation]], [[Q wave MI|Q-wave infarction]], new [[left bundle branch block]], or posterior [[infarction]] with anterior [[ST-segment depression]], complicated by [[shock]] due predominantly to [[left ventricular dysfunction]].
:* [[Hypotension]] (a [[systolic blood pressure]] of <90 mm Hg for at least 30 minutes or the need for supportive measures to maintain a [[systolic blood pressure]] of ≥90 mm Hg)
:* End-organ [[hypoperfusion]] ([[cool extremities]] or a [[urine]] output of <30 ml per hour, and a [[heart rate]] of ≥60 beats per minute)
:* [[Cardiac index]] of no more than 2.2 liters per minute per square meter of body-surface area (on support)
:* [[Pulmonary capillary wedge pressure]] of at least 15 mm Hg


==Diagnostic Criteria==
==Diagnostic Criteria==


* ''Clinical Criteria''<ref name="Califf-1994">{{Cite journal  | last1 = Califf | first1 = RM. | last2 = Bengtson | first2 = JR. | title = Cardiogenic shock. | journal = N Engl J Med | volume = 330 | issue = 24 | pages = 1724-30 | month = Jun | year = 1994 | doi = 10.1056/NEJM199406163302406 | PMID = 8190135 }}</ref><ref name="Hollenberg-1999">{{Cite journal  | last1 = Hollenberg | first1 = SM. | last2 = Kavinsky | first2 = CJ. | last3 = Parrillo | first3 = JE. | title = Cardiogenic shock. | journal = Ann Intern Med | volume = 131 | issue = 1 | pages = 47-59 | month = Jul | year = 1999 | doi =  | PMID = 10391815 }}</ref><ref name="Goldberg-1991">{{Cite journal  | last1 = Goldberg | first1 = RJ. | last2 = Gore | first2 = JM. | last3 = Alpert | first3 = JS. | last4 = Osganian | first4 = V. | last5 = de Groot | first5 = J. | last6 = Bade | first6 = J. | last7 = Chen | first7 = Z. | last8 = Frid | first8 = D. | last9 = Dalen | first9 = JE. | title = Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community-wide perspective, 1975 to 1988. | journal = N Engl J Med | volume = 325 | issue = 16 | pages = 1117-22 | month = Oct | year = 1991 | doi = 10.1056/NEJM199110173251601 | PMID = 1891019 }}</ref>
===Clinical Criteria===


:* Sustained [[hypotension]] ([[systolic blood pressure|SBP]] &lt;90 mm Hg or [[mean arterial pressure|MAP]] 30 mm Hg below baseline in preexisting [[hypertension]] for at least 30 minutes)
* Sustained [[hypotension]] for at least 30 minutes defined as [[systolic blood pressure]] <90 mmHg, or [[mean arterial pressure]] 30 mmHg below baseline in preexisting [[hypertension]], or the need for supportive measures to keep the [[systolic blood pressure]] >90 mmHg
:* Evidence of [[hypoperfusion|tissue hypoperfusion]] (such as [[oliguria]], [[cyanosis]], [[cool extremities]], and [[Altered mental status|altered mental status]])
* Clinical evidence of [[hypoperfusion|tissue hypoperfusion]] as manifested by [[oliguria]] (urine output <30 mL/hour), [[cyanosis]], [[cool extremities]], or [[Altered mental status|altered mental status]]
:* Presence of [[myocardial]] dysfunction after exclusion or correction of non-[[myocardial]] factors contributing to [[hypoperfusion|tissue hypoperfusion]] (such as [[hypovolemia]], [[hypoxia]], and [[acidosis]])
* Presence of [[myocardial]] dysfunction following exclusion or correction of possible non-[[myocardial]] factors contributing to [[hypoperfusion|tissue hypoperfusion]] such as [[hypovolemia]], [[hypoxia]], [[arrhythmia]], and [[acidosis]]<ref name="Califf-1994">{{Cite journal  | last1 = Califf | first1 = RM. | last2 = Bengtson | first2 = JR. | title = Cardiogenic shock. | journal = N Engl J Med | volume = 330 | issue = 24 | pages = 1724-30 | month = Jun | year = 1994 | doi = 10.1056/NEJM199406163302406 | PMID = 8190135 }}</ref><ref name="Hollenberg-1999">{{Cite journal  | last1 = Hollenberg | first1 = SM. | last2 = Kavinsky | first2 = CJ. | last3 = Parrillo | first3 = JE. | title = Cardiogenic shock. | journal = Ann Intern Med | volume = 131 | issue = 1 | pages = 47-59 | month = Jul | year = 1999 | doi =  | PMID = 10391815 }}</ref><ref name="Goldberg-1991">{{Cite journal  | last1 = Goldberg | first1 = RJ. | last2 = Gore | first2 = JM. | last3 = Alpert | first3 = JS. | last4 = Osganian | first4 = V. | last5 = de Groot | first5 = J. | last6 = Bade | first6 = J. | last7 = Chen | first7 = Z. | last8 = Frid | first8 = D. | last9 = Dalen | first9 = JE. | title = Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community-wide perspective, 1975 to 1988. | journal = N Engl J Med | volume = 325 | issue = 16 | pages = 1117-22 | month = Oct | year = 1991 | doi = 10.1056/NEJM199110173251601 | PMID = 1891019 }}</ref>


* ''Hemodynamic Criteria''<ref name="Califf-1994">{{Cite journal  | last1 = Califf | first1 = RM. | last2 = Bengtson | first2 = JR. | title = Cardiogenic shock. | journal = N Engl J Med | volume = 330 | issue = 24 | pages = 1724-30 | month = Jun | year = 1994 | doi = 10.1056/NEJM199406163302406 | PMID = 8190135 }}</ref><ref name="Goldberg-1991">{{Cite journal  | last1 = Goldberg | first1 = RJ. | last2 = Gore | first2 = JM. | last3 = Alpert | first3 = JS. | last4 = Osganian | first4 = V. | last5 = de Groot | first5 = J. | last6 = Bade | first6 = J. | last7 = Chen | first7 = Z. | last8 = Frid | first8 = D. | last9 = Dalen | first9 = JE. | title = Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community-wide perspective, 1975 to 1988. | journal = N Engl J Med | volume = 325 | issue = 16 | pages = 1117-22 | month = Oct | year = 1991 | doi = 10.1056/NEJM199110173251601 | PMID = 1891019 }}</ref><ref name="Forrester-1976">{{Cite journal  | last1 = Forrester | first1 = JS. | last2 = Diamond | first2 = G. | last3 = Chatterjee | first3 = K. | last4 = Swan | first4 = HJ. | title = Medical therapy of acute myocardial infarction by application of hemodynamic subsets (first of two parts). | journal = N Engl J Med | volume = 295 | issue = 24 | pages = 1356-62 | month = Dec | year = 1976 | doi = 10.1056/NEJM197612092952406 | PMID = 790191 }}</ref><ref name="Forrester-1976-2">{{Cite journal  | last1 = Forrester | first1 = JS. | last2 = Diamond | first2 = G. | last3 = Chatterjee | first3 = K. | last4 = Swan | first4 = HJ. | title = Medical therapy of acute myocardial infarction by application of hemodynamic subsets (second of two parts). | journal = N Engl J Med | volume = 295 | issue = 25 | pages = 1404-13 | month = Dec | year = 1976 | doi = 10.1056/NEJM197612162952505 | PMID = 790194 }}</ref><ref name="Reynolds-2008">{{Cite journal  | last1 = Reynolds | first1 = HR. | last2 = Hochman | first2 = JS. | title = Cardiogenic shock: current concepts and improving outcomes. | journal = Circulation | volume = 117 | issue = 5 | pages = 686-97 | month = Feb | year = 2008 | doi = 10.1161/CIRCULATIONAHA.106.613596 | PMID = 18250279 }}</ref>
===Hemodynamic Criteria===


:* Sustained [[hypotension]] ([[systolic blood pressure|SBP]] &lt;90 mm Hg or [[mean arterial pressure|MAP]] 30 mm Hg below baseline in preexisting [[hypertension]] for at least 30 minutes)
* Sustained [[hypotension]] for at least 30 minutes defined as [[systolic blood pressure]] <90 mmHg, or [[mean arterial pressure]] 30 mmHg below baseline in preexisting [[hypertension]], or the need for supportive measures to keep the [[systolic blood pressure]] >90 mmHg
:* Depressed [[cardiac index]] (&lt;1.8 L/min/m<sup>2</sup> of [[body surface area|BSA]] without support or &lt;2.0–2.2 L/min/m<sup>2</sup> of [[body surface area|BSA]] with support) in the presence of an elevated [[PCWP|wedge pressure]] (&gt;15 mm Hg).
* Depressed [[cardiac index]] (&lt;1.8 L/min/m<sup>2</sup> of [[body surface area|BSA]] without support or &lt;2.0–2.2 L/min/m<sup>2</sup> of [[body surface area|BSA]] with support)
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* Elevated [[PCWP|pulmonary capillary wedge pressure]] (&gt;15 mm Hg)
:* Adequate filling pressure (left ventricular end-diastolic pressure &gt;18 mm Hg or right ventricular end-diastolic pressure &gt;10–15 mm Hg)
* Adequate filling pressure (left ventricular end-diastolic pressure &gt;18 mm Hg or right ventricular end-diastolic pressure &gt;10–15 mm Hg)
:* Elevated [[arteriovenous oxygen difference]] (&gt;5.5 mL/dL)
* Elevated [[arteriovenous oxygen difference]] (&gt;5.5 mL/dL)<ref name="Califf-1994">{{Cite journal  | last1 = Califf | first1 = RM. | last2 = Bengtson | first2 = JR. | title = Cardiogenic shock. | journal = N Engl J Med | volume = 330 | issue = 24 | pages = 1724-30 | month = Jun | year = 1994 | doi = 10.1056/NEJM199406163302406 | PMID = 8190135 }}</ref><ref name="Goldberg-1991">{{Cite journal  | last1 = Goldberg | first1 = RJ. | last2 = Gore | first2 = JM. | last3 = Alpert | first3 = JS. | last4 = Osganian | first4 = V. | last5 = de Groot | first5 = J. | last6 = Bade | first6 = J. | last7 = Chen | first7 = Z. | last8 = Frid | first8 = D. | last9 = Dalen | first9 = JE. | title = Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community-wide perspective, 1975 to 1988. | journal = N Engl J Med | volume = 325 | issue = 16 | pages = 1117-22 | month = Oct | year = 1991 | doi = 10.1056/NEJM199110173251601 | PMID = 1891019 }}</ref><ref name="Forrester-1976">{{Cite journal  | last1 = Forrester | first1 = JS. | last2 = Diamond | first2 = G. | last3 = Chatterjee | first3 = K. | last4 = Swan | first4 = HJ. | title = Medical therapy of acute myocardial infarction by application of hemodynamic subsets (first of two parts). | journal = N Engl J Med | volume = 295 | issue = 24 | pages = 1356-62 | month = Dec | year = 1976 | doi = 10.1056/NEJM197612092952406 | PMID = 790191 }}</ref><ref name="Forrester-1976-2">{{Cite journal  | last1 = Forrester | first1 = JS. | last2 = Diamond | first2 = G. | last3 = Chatterjee | first3 = K. | last4 = Swan | first4 = HJ. | title = Medical therapy of acute myocardial infarction by application of hemodynamic subsets (second of two parts). | journal = N Engl J Med | volume = 295 | issue = 25 | pages = 1404-13 | month = Dec | year = 1976 | doi = 10.1056/NEJM197612162952505 | PMID = 790194 }}</ref><ref name="Reynolds-2008">{{Cite journal  | last1 = Reynolds | first1 = HR. | last2 = Hochman | first2 = JS. | title = Cardiogenic shock: current concepts and improving outcomes. | journal = Circulation | volume = 117 | issue = 5 | pages = 686-97 | month = Feb | year = 2008 | doi = 10.1161/CIRCULATIONAHA.106.613596 | PMID = 18250279 }}</ref>
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==References==
==References==

Latest revision as of 19:32, 10 December 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]; João André Alves Silva, M.D. [3]; Rim Halaby, M.D. [4] Syed Musadiq Ali M.B.B.S.[5]

Overview

Cardiogenic shock is the presence of tissue hypoperfusion secondary to decreased cardiac output in the context of adequate intravascular volume.

Diagnostic Criteria

Clinical Criteria

Hemodynamic Criteria

References

  1. 1.0 1.1 Califf, RM.; Bengtson, JR. (1994). "Cardiogenic shock". N Engl J Med. 330 (24): 1724–30. doi:10.1056/NEJM199406163302406. PMID 8190135. Unknown parameter |month= ignored (help)
  2. Hollenberg, SM.; Kavinsky, CJ.; Parrillo, JE. (1999). "Cardiogenic shock". Ann Intern Med. 131 (1): 47–59. PMID 10391815. Unknown parameter |month= ignored (help)
  3. 3.0 3.1 Goldberg, RJ.; Gore, JM.; Alpert, JS.; Osganian, V.; de Groot, J.; Bade, J.; Chen, Z.; Frid, D.; Dalen, JE. (1991). "Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community-wide perspective, 1975 to 1988". N Engl J Med. 325 (16): 1117–22. doi:10.1056/NEJM199110173251601. PMID 1891019. Unknown parameter |month= ignored (help)
  4. Forrester, JS.; Diamond, G.; Chatterjee, K.; Swan, HJ. (1976). "Medical therapy of acute myocardial infarction by application of hemodynamic subsets (first of two parts)". N Engl J Med. 295 (24): 1356–62. doi:10.1056/NEJM197612092952406. PMID 790191. Unknown parameter |month= ignored (help)
  5. Forrester, JS.; Diamond, G.; Chatterjee, K.; Swan, HJ. (1976). "Medical therapy of acute myocardial infarction by application of hemodynamic subsets (second of two parts)". N Engl J Med. 295 (25): 1404–13. doi:10.1056/NEJM197612162952505. PMID 790194. Unknown parameter |month= ignored (help)
  6. Reynolds, HR.; Hochman, JS. (2008). "Cardiogenic shock: current concepts and improving outcomes". Circulation. 117 (5): 686–97. doi:10.1161/CIRCULATIONAHA.106.613596. PMID 18250279. Unknown parameter |month= ignored (help)


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