CHRNA5: Difference between revisions

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{{Infobox_gene}}
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'''Neuronal acetylcholine receptor subunit alpha-5''', also known as '''nAChRα5''', is a [[protein]] that in humans is encoded by the ''CHRNA5'' [[gene]].<ref name="pmid2004777">{{cite journal|authorlink4=Huda Zoghbi | vauthors = Eng CM, Kozak CA, Beaudet AL, Zoghbi HY | title = Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse | journal = Genomics | volume = 9 | issue = 2 | pages = 278–82 |date=Apr 1991 | pmid = 2004777 | pmc =  | doi =10.1016/0888-7543(91)90253-B  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = }}</ref> The protein encoded by this gene is a subunit of certain [[nicotinic acetylcholine receptor]]s (nAchR).
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== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Nicotinic acetylcholine receptors ([[nicotinic acetylcholine receptor|nAChRs]]), such as CHRNA5, are members of a superfamily of [[ligand-gated ion channel]]s that mediate fast signal transmission at [[synapse]]s. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 5
| HGNCid = 1959
| Symbol = CHRNA5
| AltSymbols =;
| OMIM = 118505
| ECnumber = 
| Homologene = 55485
| MGIid = 87889
| GeneAtlas_image1 = PBB_GE_CHRNA5_206533_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1138
    | Hs_Ensembl = ENSG00000169684
    | Hs_RefseqProtein = NP_000736
    | Hs_RefseqmRNA = NM_000745
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 76644961
    | Hs_GenLoc_end = 76673493
    | Hs_Uniprot = P30532
    | Mm_EntrezGene = 110835
    | Mm_Ensembl = ENSMUSG00000035594
    | Mm_RefseqmRNA = XM_973541
    | Mm_RefseqProtein = XP_978635
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 54779234
    | Mm_GenLoc_end = 54805916
    | Mm_Uniprot = 
  }}
}}
'''Cholinergic receptor, nicotinic, alpha 5''', also known as '''CHRNA5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = }}</ref>


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== Interactive pathway map ==
{{PBB_Summary
{{NicotineDopaminergicActivity_WP1602|highlight=CHRNA5}}
| section_title =  
| summary_text = Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = }}</ref>
}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1-46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 }}
*{{cite journal  | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 | series=Reviews of Physiology, Biochemistry and Pharmacology  | isbn=978-3-540-01365-5 }}
*{{cite journal  | author=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. |journal=Genomics |volume=13 |issue= 4 |pages= 962-7 |year= 1992 |pmid= 1505988 |doi=  }}
*{{cite journal  | vauthors=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans |journal=Genomics |volume=13 |issue= 4 |pages= 962–7 |year= 1992 |pmid= 1505988 |doi=10.1016/0888-7543(92)90008-G }}
*{{cite journal  | author=Chini B, Clementi F, Hukovic N, Sher E |title=Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1572-6 |year= 1992 |pmid= 1542648 |doi=  }}
*{{cite journal  | vauthors=Chini B, Clementi F, Hukovic N, Sher E |title=Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1572–6 |year= 1992 |pmid= 1542648 |doi= 10.1073/pnas.89.5.1572| pmc=48494 }}
*{{cite journal  | author=Raimondi E, Rubboli F, Moralli D, ''et al.'' |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. |journal=Genomics |volume=12 |issue= 4 |pages= 849-50 |year= 1992 |pmid= 1572664 |doi=  }}
*{{cite journal  | author=Raimondi E |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits |journal=Genomics |volume=12 |issue= 4 |pages= 849–50 |year= 1992 |pmid= 1572664 |doi= 10.1016/0888-7543(92)90324-L  |name-list-format=vanc| author2=Rubboli F | author3=Moralli D  | display-authors=3  | last4=Chini | first4=Bice  | last5=Fornasari  | first5=Diego  | last6=Tarroni  | first6=Paola  | last7=De Carli  | first7=Luigi  | last8=Clementi  | first8=Francesco }}
*{{cite journal | author=Eng CM, Kozak CA, Beaudet AL, Zoghbi HY |title=Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. |journal=Genomics |volume=9 |issue= 2 |pages= 278-82 |year= 1991 |pmid= 2004777 |doi=  }}
*{{cite journal  | author=Elliott KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842  |name-list-format=vanc| author2=Ellis SB  | author3=Berckhan KJ  | display-authors=3  | last4=Urrutia  | first4=Arturo  | last5=Chavez-Noriega  | first5=Laura E.  | last6=Johnson  | first6=Edwin C.  | last7=Veliçelebi  | first7=Gönül  | last8=Harpold  | first8=Michael M. }}
*{{cite journal  | author=Elliott KJ, Ellis SB, Berckhan KJ, ''et al.'' |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217-28 |year= 1997 |pmid= 8906617 |doi=  }}
*{{cite journal  | vauthors=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–14 |year= 1997 |pmid= 9009220 |doi=10.1016/S0014-5793(96)01383-X }}
*{{cite journal  | author=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309-14 |year= 1997 |pmid= 9009220 |doi=  }}
*{{cite journal  | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | author=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433-42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | vauthors=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311–20 |year= 1998 |pmid= 9655874 |doi=  }}
*{{cite journal  | author=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311-20 |year= 1998 |pmid= 9655874 |doi=  }}
*{{cite journal  | author=Lentz TL |title=Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 480–4 |year= 2000 |pmid= 10679230 |doi= 10.1006/bbrc.2000.2155 }}
*{{cite journal  | author=Lentz TL |title=Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 480-4 |year= 2000 |pmid= 10679230 |doi= 10.1006/bbrc.2000.2155 }}
*{{cite journal  | vauthors=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789–96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313 | pmc=1573006 }}
*{{cite journal  | author=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach. |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789-96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Soldà G |title=In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs |journal=Gene |volume=345 |issue= 2 |pages= 155–64 |year= 2005 |pmid= 15716100 |doi= 10.1016/j.gene.2004.12.005 |name-list-format=vanc| author2=Boi S  | author3=Duga S  | display-authors=3  | last4=Fornasari  | first4=Diego  | last5=Benfante  | first5=Roberta  | last6=Malcovati  | first6=Massimo  | last7=Tenchini  | first7=Maria Luisa }}
*{{cite journal  | author=Soldà G, Boi S, Duga S, ''et al.'' |title=In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs. |journal=Gene |volume=345 |issue= 2 |pages= 155-64 |year= 2005 |pmid= 15716100 |doi= 10.1016/j.gene.2004.12.005 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CHRNA5+protein,+human}}
* {{MeshName|CHRNA5+protein,+human}}
* {{UCSC gene info|CHRNA5}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
[[Category:Nicotinic acetylcholine receptors]]
 
 
{{membrane-protein-stub}}

Latest revision as of 16:08, 8 October 2017

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Wikidata
View/Edit Human

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.[1][2] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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<imagemap> Image:NicotineDopaminergic_WP1602.png
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

References

  1. ↑ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
  2. ↑ 2.0 2.1 "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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