CADPS: Difference between revisions

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Latest revision as of 11:23, 11 January 2018

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.^[1]^[2]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.^[2]

References

↑ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133.
↑ ^2.0 ^2.1 "Entrez Gene: CADPS Ca2+-dependent secretion activator".

External links

Human CADPS genome location and CADPS gene details page in the UCSC Genome Browser.
Human CAPS genome location and CAPS gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C.". J. Biol. Chem. 267 (33): 23972–81. PMID 1429734.
Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis". J. Biol. Chem. 272 (32): 19637–40. doi:10.1074/jbc.272.32.19637. PMID 9289490.
Loyet KM, Kowalchyk JA, Chaudhary A, et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis". J. Biol. Chem. 273 (14): 8337–43. doi:10.1074/jbc.273.14.8337. PMID 9525942.
Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis". Neuron. 21 (1): 137–45. doi:10.1016/S0896-6273(00)80521-8. PMID 9697858.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family". Genomics. 81 (3): 279–91. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function". J. Biol. Chem. 278 (52): 52802–9. doi:10.1074/jbc.M304727200. PMID 14530279.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid1516133-1] Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CADPS Ca2+-dependent secretion activator".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Calcium-dependent secretion activator 1''' is a [[protein]] that in humans is encoded by the ''CADPS'' [[gene]].<ref name="pmid1516133">{{cite journal | vauthors = Walent JH, Porter BW, Martin TF | title = A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells | journal = Cell | volume = 70 | issue = 5 | pages = 765–75 |date=Oct 1992 | pmid = 1516133 | pmc =  | doi =10.1016/0092-8674(92)90310-9  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CADPS Ca2+-dependent secretion activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8618| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image = PBB_Protein_CADPS_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wi1.
- | PDB = {{PDB2|1wi1}}
- | Name = Ca2+-dependent secretion activator
- | HGNCid = 1426
- | Symbol = CADPS
- | AltSymbols =; CAPS; CAPS1; KIAA1121
- | OMIM = 604667
- | ECnumber =
- | Homologene = 2755
- | MGIid = 1350922
-  | Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
-  | Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0031410 |text = cytoplasmic vesicle}} {{GNF_GO|id=GO:0045202 |text = synapse}}
- | Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016050 |text = vesicle organization and biogenesis}} {{GNF_GO|id=GO:0050432 |text = catecholamine secretion}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8618
-    | Hs_Ensembl = ENSG00000163618
-    | Hs_RefseqProtein = NP_003707
-    | Hs_RefseqmRNA = NM_003716
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 62359062
-    | Hs_GenLoc_end = 62836094
-    | Hs_Uniprot = Q9ULU8
-    | Mm_EntrezGene = 27062
-    | Mm_Ensembl = ENSMUSG00000054423
-    | Mm_RefseqmRNA = NM_001042617
-    | Mm_RefseqProtein = NP_001036082
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 11165827
-    | Mm_GenLoc_end = 11616320
-    | Mm_Uniprot = Q80TJ1
-  }}
-}}
-'''Ca2+-dependent secretion activator''', also known as '''CADPS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CADPS Ca2+-dependent secretion activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8618| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.<ref name="entrez">{{cite web | title = Entrez Gene: CADPS Ca2+-dependent secretion activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8618| accessdate = }}</ref>
+| summary_text = CADPS encodes a novel neural/[[endocrine]]-specific cytosolic and [[peripheral membrane protein]] required for the Ca2+-regulated [[exocytosis]] of [[Vesicle (biology and chemistry)#Secretory vesicles|secretory vesicles]]. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of [[phosphatidylinositol 4,5-bisphosphate]] (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CADPS}}
+* {{UCSC gene info|CAPS}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
+*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  |display-authors=etal}}
-*{{cite journal  | author=Nishizaki T, Walent JH, Kowalchyk JA, Martin TF |title=A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23972-81 |year= 1992 |pmid= 1429734 |doi=  }}
+*{{cite journal  | vauthors=Nishizaki T, Walent JH, Kowalchyk JA, Martin TF |title=A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23972–81 |year= 1992 |pmid= 1429734 |doi=  }}
-*{{cite journal  | author=Walent JH, Porter BW, Martin TF |title=A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. |journal=Cell |volume=70 |issue= 5 |pages= 765-75 |year= 1992 |pmid= 1516133 |doi=  }}
+*{{cite journal  | vauthors=Ann K, Kowalchyk JA, Loyet KM, Martin TF |title=Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19637–40 |year= 1997 |pmid= 9289490 |doi=10.1074/jbc.272.32.19637  }}
-*{{cite journal  | author=Ann K, Kowalchyk JA, Loyet KM, Martin TF |title=Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19637-40 |year= 1997 |pmid= 9289490 |doi=  }}
+*{{cite journal  | vauthors=Loyet KM, Kowalchyk JA, Chaudhary A |title=Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 8337–43 |year= 1998 |pmid= 9525942 |doi=10.1074/jbc.273.14.8337  |display-authors=etal}}
-*{{cite journal  | author=Loyet KM, Kowalchyk JA, Chaudhary A, ''et al.'' |title=Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 8337-43 |year= 1998 |pmid= 9525942 |doi=  }}
+*{{cite journal  | vauthors=Berwin B, Floor E, Martin TF |title=CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis. |journal=Neuron |volume=21 |issue= 1 |pages= 137–45 |year= 1998 |pmid= 9697858 |doi=10.1016/S0896-6273(00)80521-8  }}
-*{{cite journal  | author=Berwin B, Floor E, Martin TF |title=CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis. |journal=Neuron |volume=21 |issue= 1 |pages= 137-45 |year= 1998 |pmid= 9697858 |doi=  }}
+*{{cite journal  | vauthors=Hirosawa M, Nagase T, Ishikawa K |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=10.1093/dnares/6.5.329  |display-authors=etal}}
-*{{cite journal  | author=Hirosawa M, Nagase T, Ishikawa K, ''et al.'' |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329-36 |year= 2000 |pmid= 10574461 |doi=  }}
+*{{cite journal  | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902  | pmc=187542 }}
-*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Cisternas FA, Vincent JB, Scherer SW, Ray PN |title=Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. |journal=Genomics |volume=81 |issue= 3 |pages= 279–91 |year= 2003 |pmid= 12659812 |doi=10.1016/S0888-7543(02)00040-X  }}
-*{{cite journal  | author=Cisternas FA, Vincent JB, Scherer SW, Ray PN |title=Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. |journal=Genomics |volume=81 |issue= 3 |pages= 279-91 |year= 2003 |pmid= 12659812 |doi=  }}
+*{{cite journal  | vauthors=Speidel D, Varoqueaux F, Enk C |title=A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52802–9 |year= 2004 |pmid= 14530279 |doi= 10.1074/jbc.M304727200 |display-authors=etal}}
-*{{cite journal  | author=Speidel D, Varoqueaux F, Enk C, ''et al.'' |title=A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52802-9 |year= 2004 |pmid= 14530279 |doi= 10.1074/jbc.M304727200 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Binda AV, Kabbani N, Levenson R |title=Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). |journal=Biochem. Pharmacol. |volume=69 |issue= 10 |pages= 1451–61 |year= 2005 |pmid= 15857609 |doi= 10.1016/j.bcp.2005.02.015 }}
-*{{cite journal  | author=Binda AV, Kabbani N, Levenson R |title=Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). |journal=Biochem. Pharmacol. |volume=69 |issue= 10 |pages= 1451-61 |year= 2005 |pmid= 15857609 |doi= 10.1016/j.bcp.2005.02.015 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=8618}}
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+{{gene-3-stub}}
-{{WikiDoc Sources}}

CADPS: Difference between revisions

Latest revision as of 11:23, 11 January 2018

References

External links

Further reading

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