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{{CMG}}; '''Associate Editor-In-Chief:'''  
{{CMG}}; '''Associate Editor-In-Chief:'''


==Overview==
== Overview ==


[[Blurred vision]] is a common [[ophthalmic]] symptom where vision becomes less sharp and there is an inability to see small details. Alterations of the [[optical]] surfaces or media for which the [[visual axis]] travels typically causes [[blurred vision]]. Refractive errors, such as [[near-sightedness]] and [[far-sightedness]] cause the majority of [[blurred vision]] complaints. Most vision complaints can be corrected with glasses. [[Blurred vision]] can be due to multiple issues but mostly present in [[neurologic]] and [[ophthalmologic]] diseases.
==Historical Perspective==
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
 
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
 
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].


==Historical Perspective==
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
*Visual function assessment and [[blurred vision]] detection, in particular, has been susceptible to the invention of [[snellen chart]]. [[Snellen chart]] is an eye chart that can be used to measure visual acuity. [[Snellen chart]] is named after the Dutch ophthalmologist Herman Snellen, who developed the chart in 1862 who began diagnosing vision problems by asking people to look at a chart on a wall and tell him what they could see. Dr. Snellen also created a chart called the Tumbling E chart, which can be used by people who cannot read, or by young children who don’t know the alphabet. Instead of using different letters, the Tumbling E eye chart uses a capital letter E that faces in different directions.<ref name="Keeler2002">{{cite journal|last1=Keeler|first1=C. Richard|title=The Ophthalmoscope in the Lifetime of Hermann von Helmholtz|journal=Archives of Ophthalmology|volume=120|issue=2|year=2002|pages=194|issn=0003-9950|doi=10.1001/archopht.120.2.194}}</ref>


*The other chart testing visual acuity is [[logMAR chart]] which also called [[Bailey-Lovie chart]] or [[ETDRS chart]]. The chart was developed at the National Vision Research Institute of Australia in 1976, and is designed to enable a more accurate estimate of acuity than the other one. Visual acuity measurements using a [[logMAR chart]] have been shown to be twice as repeatable as those from a [[snellen chart]].<ref name="Rosser2001">{{cite journal|last1=Rosser|first1=D A|title=The development of a "reduced logMAR" visual acuity chart for use in routine clinical practice|journal=British Journal of Ophthalmology|volume=85|issue=4|year=2001|pages=432–436|issn=00071161|doi=10.1136/bjo.85.4.432}}</ref>
There have been several outbreaks of [disease name], including -----.


In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
==Classification==
==Classification==
*Based on the duration of symptoms, [[blurred vision]] may be classified as either [[acute]] or [[chronic]].
There is no established system for the classification of [disease name].
 
OR
 
[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
 
OR
 
[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
 
OR
 
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.


OR
If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
OR
The staging of [malignancy name] is based on the [staging system].
OR
There is no established system for the staging of [malignancy name].
==Pathophysiology==
==Pathophysiology==
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].


OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
==Causes==
==Causes==
Disease name] may be caused by [cause1], [cause2], or [cause3].


===Causes by Organ System===
OR


{| style="width:80%; height:100px" border="1"
Common causes of [disease] include [cause1], [cause2], and [cause3].
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" |
[[Hypertension]],
[[Neurocardiogenic Syncope]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Chemical / poisoning'''
| bgcolor="Beige" |
[[Hawaiian baby woodrose]],
[[Monocrotophos]],
[[Mushroom poisoning]],


|-
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
|- bgcolor="LightSteelBlue"
|'''Dermatologic'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Drug Side Effect'''
| bgcolor="Beige" |
[[3-Quinuclidinyl benzilate]],
[[Acetazolamide]],
[[Acetohexamide (patient information)]],
[[Aclidinium bromide]],
[[Aldicarb]],
[[Alfuzosin (patient information)]],
[[Alpha-Methyltryptamine]],
[[Amantadine (patient information)]],
[[Amitriptyline (patient information)]],
[[Amitriptyline and Perphenazine (patient information)]],
[[Amphotericin B Injection (patient information)]],
[[Amprenavir (patient information)]],
[[Anastrozole (patient information)]],
[[Anticholinergic]],
[[Antihistamine]],
[[Apraclonidine]],
[[Aripiprazole (patient information)]],
[[Atropine]],
[[Avacor]],
[[Azelastine Ophthalmic (patient information)]],
[[Benzatropine]],
[[Benzodiazepine]],
[[Bepridil (patient information)]],
[[Besifloxacin]],
[[Bimatoprost]],
[[Biperiden]],
[[Bismuth Subsalicylate, Metronidazole, and Tetracycline Combination (patient information)]],
[[Bortezomib (patient information)]],
[[Botulinum toxin]],
[[Brinzolamide Ophthalmic (patient information)]],
[[Bupivacaine]],
[[Butanethiol]],
[[Butorphanol]],
[[Carvedilol (patient information)]],
[[Cetuximab Injection (patient information)]],
[[Cevimeline]],
[[Chlordiazepoxide (patient information)]],
[[Chlordiazepoxide and Clidinium Bromide (patient information)]],
[[Chloroquine Phosphate Oral (patient information)]],
[[Chlorpropamide (patient information)]],
[[Clonazepam (patient information)]],
[[Clorazepate (patient information)]],[[Clobazam]],
[[Colistimethate Injection (patient information)]], [[Crizotinib]],
[[Cyclizine]],
[[Cetirizine hydrochloride]],
[[Cyclopentolate]],
[[Cyclosporine Ophthalmic (patient information)]],
[[Cytarabine (patient information)]],
[[Cytarabine]],
[[Dapiprazole Ophthalmic (patient information)]],
[[Darifenacin (patient information)]],
[[Darunavir (patient information)]],
[[Dapsone]],
[[Desipramine (patient information)]],
[[Dexmethylphenidate]],
[[Dextromethorphan]],
[[Diazepam]],
[[Diazinon]],
[[Diclofenac Ophthalmic (patient information)]],
[[Dicyclomine (patient information)]],
[[Didanosine (patient information)]],
[[Diethylcathinone]],
[[Diethylpropion (patient information)]],
[[Diflunisal]],
[[Difluoroethane]],
[[Digoxin]],
[[Diphenhydramine]],
[[Dipivefrin Ophthalmic (patient information)]],
[[Disopyramide (patient information)]],
[[Disulfiram]],
[[Dorzolamide and Timolol Ophthalmic (patient information)]],
[[Dosulepin hydrochloride]],
[[Duloxetine]],
[[Enfuvirtide Injection (patient information)]],
[[Ergoloid Mesylates (patient information)]],
[[Eslicarbazepine acetate]],
[[Estazolam (patient information)]],
[[Ethcathinone]],
[[Ethchlorvynol]],
[[Etodolac]],
[[Etonogestrel and Ethinyl Estradiol Vaginal Ring]],
[[Exenatide Injection (patient information)]],
[[Fenoprofen (patient information)]],
[[Fexofenadine and Pseudoephedrine (patient information)]],
[[Flavoxate]],
[[Flumazenil]],
[[Fluphenazine (patient information)]], [[Flurazepam]],
[[Fosamprenavir (patient information)]],
[[Furosemide (patient information)]],
[[Gabapentin (patient information)]],
[[Gamma-Hydroxybutyric acid]],
[[Gatifloxacin (patient information)]],
[[Gemfibrozil (patient information)]],
[[Glimepiride (patient information)]],
[[Glipizide (patient information)]],
[[Glyburide (patient information)]],
[[Glyburide and Metformin (patient information)]],
[[Glycopyrrolate]],
[[Granisetron (patient information)]],
[[Haloperidol]],
[[Homatropine]],
[[Hydrocortisone, Neomycin, and Polymyxin (patient information)]],
[[Hydrochlorothiazide]]
[[Hydroxychloroquine (patient information)]],
[[Hydroxypropyl cellulose]],
[[Hyoscyamine (patient information)]],
[[Imipramine (patient information)]],
[[Indapamide (patient information)]],
[[Indomethacin (patient information)]],
[[Infliximab Injection (patient information)]],
[[Insulin Aspart (rDNA Origin) Injection (patient information)]],
[[Insulin Detemir (rDNA Origin) Injection (patient information)]],
[[Insulin Glargine (rDNA origin) Injection (patient information)]],
[[Insulin Glulisine (rDNA origin) Injection (patient information)]],
[[Insulin Human (rDNA Origin) Inhalation (patient information)]],
[[Insulin Injection (patient information)]],
[[Insulin lispro injection (patient information)]],
[[Ipratropium and Albuterol Inhalation (patient information)]],
[[Ipratropium Oral Inhalation (patient information)]],
[[Isosorbide (patient information)]],
[[Ivabradine]],
[[Ketorolac Ophthalmic (patient information)]],
[[Ketotifen Ophthalmic (patient information)]],
[[Lacosamide]],
[[Lamotrigine (patient information)]],
[[Lanthanum (patient information)]],
[[Levobupivacaine]],
[[Lidocaine Viscous (patient information)]],
[[Lodoxamide Ophthalmic (patient information)]],
[[Lofepramine]], [[Lorcaserin]],
[[Lomotil]],
[[Lorazepam (patient information)]],
[[Loxapine Oral (patient information)]],
[[Meclofenamate (patient information)]],
[[Medroxyprogesterone (patient information)]],
[[Mefenamic acid]],
[[Megestrol (patient information)]],
[[Meperidine (patient information)]],
[[Mepenzolate bromide]],
[[Metformin (patient information)]],
[[Methocarbamol Oral (patient information)]],
[[Methotrexate (patient information)]],
[[Methylphenidate Transdermal (patient information)]],
[[Metipranolol]],
[[Metipranolol Ophthalmic (patient information)]],
[[Miconazole Injection (patient information)]],
[[Miglitol (patient information)]],
[[Minocycline Oral (patient information)]],
[[Minoxidil]], [[Mitomycin]],
[[Moclobemide]],
[[Moricizine (patient information)]],
[[Morphine Oral (patient information)]],
[[Morphine rectal (patient information)]],
[[Motofen]],
[[Moxifloxacin ophthalmic (patient information)]],
[[Nalbuphine]],
[[Naltrexone (patient information)]],
[[Nateglinide oral (patient information)]],
[[Nedocromil ophthalmic (patient information)]],
[[Nefazodone (patient information)]],
[[Nepafenac ophthalmic (patient information)]],
[[Niacin]],
[[Nitroglycerin ointment (patient information)]],
[[Nitroglycerin skin patches (patient information)]],
[[Nitroglycerin Tablets, Capsules, and Sprays (patient information)]],
[[Norethindrone (patient information)]],
[[Nortriptyline (patient information)]],
[[Ofloxacin ophthalmic (patient information)]],
[[Olanzapine (patient information)]],
[[Olopatadine (ophthalmic)]],
[[Olsalazine]],
[[Ondansetron injection (patient information)]],
[[Oprelvekin]],
[[Orphenadrine (patient information)]],
[[Oxazepam (patient information)]],
[[Oxcarbazepine]],
[[Oxybutynin (patient information)]],
[[Oxybutynin transdermal (patient information)]],
[[Paliperidone (patient information)]],
[[Pegaptanib]],
[[Peginterferon alfa-2a (patient information)]],
[[Pentamidine Isethionate]],
[[Perphenazine oral (patient information)]],
[[Phentermine]],
[[Phenytoin oral (patient information)]],
[[Pilocarpine ophthalmic (patient information)]],
[[Pioglitazone (patient information)]],
[[Pralidoxime]],
[[Prazepam (patient information)]],
[[Prazosin and polythiazide (patient information)]],
[[Prednisolone ophthalmic (patient information)]],
[[Pregabalin (patient information)]],
[[Primaquine (patient information)]],
[[Primidone (patient information)]],
[[Prochlorperazine]],
[[Procyclidine (patient information)]],
[[Prograf]],
[[Promethazine (patient information)]],
[[Propafenone (patient information)]],
[[Propantheline (patient information)]],
[[Protriptyline (patient information)]],
[[Pyridostigmine (patient information)]],
[[Quetiapine (patient information)]],
[[Quinidine Oral (patient information)]],
[[Rasagiline (patient information)]],
[[Repaglinide (patient information)]],
[[Rimexolone]],
[[Risperidone (patient information)]],
[[Rituximab injection (patient information)]],
[[Rivastigmine (patient information)]],
[[Rogaine (drug)]],
[[Ropivacaine]],
[[Rosiglitazone (patient information)]],
[[Salmeterol oral inhalation (patient information)]],
[[Scopolamine]],
[[Scopolamine patch (patient information)]],
[[Sildenafil (patient information)]],
[[Sodium oxybate (patient information)]],
[[Solifenacin (patient information)]],
[[Spironolactone (patient information)]],
[[Sulindac (patient information)]],
[[Tacrolimus]],
[[Tadalafil (patient information)]],
[[Tamsulosin (patient information)]],
[[Tartrazine]],
[[Tegaserod (patient information)]],
[[Telithromycin (patient information)]],
[[Temazepam (patient information)]],
[[Terazosin (patient information)]],
[[Tetrahydrozoline Ophthalmic (patient information)]],
[[Thalidomide]],
[[Thallous Chloride Tl 201]],
[[Thioridazine hydrochloride]],
[[Thiothixene Oral (patient information)]],
[[Tiludronate (patient information)]],
[[Tiotropium Oral Inhalation (patient information)]],
[[Tipranavir (patient information)]],
[[Tobramycin Ophthalmic (patient information)]],
[[Tolazamide (patient information)]],
[[Tolbutamide (patient information)]],
[[Tranylcypromine (patient information)]],
[[Travoprost Ophthalmic (patient information)]],
[[Trazodone (patient information)]],
[[Triazolam (patient information)]],
[[Tricyclic antidepressant]],
[[Trifluoperazine Oral (patient information)]],
[[Trihexyphenidyl]],
[[Trimethobenzamide (patient information)]],
[[Trimipramine (patient information)]],
[[Tropicamide]],
[[Trospium]],
[[Trospium (patient information)]],
[[Valproic Acid (patient information)]],
[[Vardenafil (patient information)]],
[[Venlafaxine]],
[[Verteporfin]],
[[Voriconazole (patient information)]],
[[Vorinostat (patient information)]],
[[Ziprasidone (patient information)]],
[[Zolpidem (patient information)]],
[[Zopiclone]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Ear Nose Throat'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Endocrine'''
| bgcolor="Beige" |
[[Diabetes insipidus]],
[[Diabetes mellitus]],
[[Graves ophthalmopathy]],
[[multiple endocrine neoplasia type 1]]
[[Prediabetes]],


|-
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click [https://www.wikidoc.org/index.php/Pericarditis_causes#Overview here].
|- bgcolor="LightSteelBlue"
==Differentiating ((Page name)) from other Diseases==
|'''Environmental'''
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Gastroenterologic'''
| bgcolor="Beige" |
[[Insulinoma]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Genetic'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Hematologic'''
| bgcolor="Beige" |[[Hyperviscosity]]


|-
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
|- bgcolor="LightSteelBlue"
==Epidemiology and Demographics==
|'''Iatrogenic'''
The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
| bgcolor="Beige" |No underlying causes
 
|-
OR
|- bgcolor="LightSteelBlue"
 
|'''Infectious Disease'''
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
| bgcolor="Beige" |
[[Botulism]],
[[Cryptococcosis]],
[[Cysticercosis]],
[[Cytomegalovirus retinitis]],
[[Henipavirus]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Musculoskeletal / Ortho'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Neurologic'''
| bgcolor="Beige" |
[[Cerebral arteriovenous malformation]],
[[Hwabyeong]],
[[Machado-Joseph disease]],
[[Migraine]],
[[Multiple sclerosis]],
[[Neuroglycopenia]],
[[Post-concussion syndrome]],
[[Subdural hematoma]],
[[Vertebrobasilar insufficiency]],
Chiasma syndrome,


|-
In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate of [number range]%.
|- bgcolor="LightSteelBlue"
|'''Nutritional / Metabolic'''
| bgcolor="Beige" |
[[Hypoglycemia]],
[[Ornithine translocase deficiency]],


|-
|- bgcolor="LightSteelBlue"
|'''Obstetric/Gynecologic'''
| bgcolor="Beige" |
[[HELLP syndrome]],


|-
Patients of all age groups may develop [disease name].
|- bgcolor="LightSteelBlue"
|'''Oncologic'''
| bgcolor="Beige" |
[[Intraocular lymphoma]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Opthalmologic'''
| bgcolor="Beige" |
[[Acute posterior multifocal placoid pigment epitheliopathy]],
[[Asthenopia]],
[[Astigmatism (eye)]],
[[Central serous retinopathy]],
[[Coats disease]],
[[Convergence insufficiency]],
[[Corneal abrasion]],
[[Diabetic retinopathy]],
[[Fuchs' dystrophy]],
[[Fungal keratitis]],
[[Hyperopia]],
[[Iritis]],
[[Macular degeneration]],
[[Optic neuritis]],
[[Refractive error]],
[[Reiter's Syndrome]],
[[Thygeson's superficial punctate keratopathy]],
[[Uveitis]],
Dry eye, poor tear film,
Extraocular muscle paralysis


|-
The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
|- bgcolor="LightSteelBlue"
|'''Overdose / Toxicity'''
| bgcolor="Beige" |
[[Aliskiren (patient information)]],
[[Amiodarone Oral (patient information)]],
[[Atenolol (patient information)]],
[[Benztropine Mesylate Oral (patient information)]],
[[Bisoprolol (patient information)]],
[[Bosentan (patient information)]],
[[Buprenorphine Sublingual and Buprenorphine and Naloxone Sublingual (patient information)]],
[[Buspirone (patient information)]],
[[Carbamazepine (patient information)]],
[[Clitocybe dealbata]],
[[Clomiphene (patient information)]],
[[Deadly nightshade]],
[[Dextroamphetamine and Amphetamine (patient information)]],
[[Dihydroergotamine Injection and Nasal Spray (patient information)]],
[[Doxepin Topical (patient information)]],
[[Eplerenone (patient information)]],
[[Esomeprazole (patient information)]],
[[Fluticasone and Salmeterol Oral Inhalation (patient information)]],
[[Isocarboxazid (patient information)]],
[[Levalbuterol Oral Inhalation (patient information)]],
[[Lidocaine Transdermal (patient information)]],
[[Lisinopril and Hydrochlorothiazide (patient information)]],
[[Meperidine (patient information)]],
[[Morphine Oral (patient information)]],
[[Muscarine]],
[[Niacin]],
[[Olmesartan (patient information)]],
[[Omeprazole (patient information)]],
[[Oprelvekin]],
[[Pamidronate injection (patient information)]],
[[Pergolide (patient information)]],
[[Pimozide (patient information)]],
[[Primaquine (patient information)]],
[[Risperidone (patient information)]],
[[Rivastigmine (patient information)]],
[[Salmeterol oral inhalation (patient information)]],
[[Sulindac (patient information)]],
[[Tamsulosin (patient information)]],
[[Temik]],
[[Tiotropium Oral Inhalation (patient information)]],
[[Topiramate]],
[[Vardenafil (patient information)]],
[[Hypervitaminosis A]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Psychiatric'''
| bgcolor="Beige" |
[[Panic attack]],


|-
[Disease name] commonly affects individuals younger than/older than [number of years] years of age.
|- bgcolor="LightSteelBlue"
|'''Pulmonary'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Renal / Electrolyte'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Rheum / Immune / Allergy'''
| bgcolor="Beige" |
[[Temporal arteritis]],
[[Myasthenia]]


|-
OR
|- bgcolor="LightSteelBlue"
|'''Sexual'''
| bgcolor="Beige" |No underlying causes
|-
|- bgcolor="LightSteelBlue"
|'''Trauma'''
| bgcolor="Beige" |
[[Traumatic brain injury]],


|-
[Chronic disease name] is usually first diagnosed among [age group].
|- bgcolor="LightSteelBlue"
|'''Urologic'''
| bgcolor="Beige" |[[Reiter's Syndrome]],


|-
OR
|- bgcolor="LightSteelBlue"
|'''Miscellaneous'''
| bgcolor="Beige" |
[[Anesthesia]],
[[Computer vision syndrome]],
[[Orthostatic hypotension]],
[[Carbon dioxide narcosis]],


|-
[Acute disease name] commonly affects [age group].
|}


==Causes in Alphabetical Order<ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>==


{{MultiCol}}
There is no racial predilection to [disease name].
*[[3-Quinuclidinyl benzilate]]
*[[Acetazolamide]]
*[[Acetohexamide ]]
*[[Acute angle-closure glaucoma]]
*[[Acute posterior multifocal placoid pigment epitheliopathy]]
*[[Aldicarb]]
*[[Alfuzosin ]]
*[[Aliskiren ]]
*[[Alpha-Methyltryptamine]]
*[[Amantadine ]]
*[[Amiodarone Oral ]]
*[[Amitriptyline ]]
*[[Amphotericin B Injection ]]
*[[Amprenavir ]]
*[[Anastrozole ]]
*[[Anesthesia]]
*[[Anticholinergic]]
*[[Antihistamine]]
*[[Aripiprazole ]]
*[[Asthenopia]]
*[[Astigmatism (eye)]]
*[[Atenolol ]]
*[[Atropine]]
*[[Avacor]]
*[[Azelastine Ophthalmic ]]
*[[Belladonna Alkaloid Combinations and Phenobarbital ]]
*[[Benzatropine]]
*[[Benzodiazepine]]
*[[Benztropine Mesylate Oral ]]
*[[Bepridil ]]
*[[Bimatoprost]]
*[[Biperiden]]
*[[Bismuth Subsalicylate, Metronidazole, and Tetracycline Combination ]]
*[[Bisoprolol ]]
*[[Bortezomib ]]
*[[Bosentan ]]
*[[Botulinum toxin]]
*[[Botulism]]
*[[Brimonidine Ophthalmic ]]
*[[Brinzolamide Ophthalmic ]]
*[[Bupivacaine]]
*[[Buprenorphine Sublingual and Buprenorphine and Naloxone Sublingual ]]
*[[Buspirone ]]
*[[Butanethiol]]
*[[Butorphanol]]
*[[Carbamazepine ]]
*[[Carbon dioxide narcosis]]
*[[Carvedilol ]]
*[[Cataracts]]
*[[Central serous retinopathy]]
*[[Cerebral arteriovenous malformation]]
*[[Cetuximab Injection ]]
*[[Cevimeline]]
*Chiasma syndrome
*[[Chlordiazepoxide ]]
*[[Chloroquine]]
*[[Chlorpropamide ]]
*[[Clitocybe dealbata]]
*[[Clomiphene ]]
*[[Clonazepam ]]
*[[Clorazepate ]]
*[[Coats disease]]
*[[Colistimethate Injection ]]
*[[Computer vision syndrome]]
*Congenital disorders
*[[Conjunctivitis]]
*[[Convergence insufficiency]]
*[[Corneal abrasion]]
*[[Corneal irregularity or abrasion]]
*[[Cryptococcosis]]
*[[Cyclizine]]
*[[Cyclosporine Ophthalmic ]]
*[[Cysticercosis]]
*[[Cytarabine ]]
*[[Cytomegalovirus retinitis]]
*[[Dapiprazole Ophthalmic ]]
*[[Darifenacin ]]
*[[Darunavir ]]
*[[Deadly nightshade]]
*[[Desipramine ]]
*[[Dexmethylphenidate]]
*[[Dextroamphetamine and Amphetamine ]]
*[[Dextromethorphan]]
*[[Diabetes insipidus]]
*[[Diabetes mellitus]]
*[[Diabetic retinopathy]]
*[[Diazepam]]
*[[Diazinon]]
*[[Diclofenac Ophthalmic ]]
*[[Dicyclomine ]]
*[[Didanosine ]]
*[[Diethylcathinone]]
*[[Diethylpropion ]]
*[[Difluoroethane]]
*[[Digoxin]]
*[[Dihydroergotamine Injection and Nasal Spray ]]
*[[Diphenhydramine]]
*[[Dipivefrin Ophthalmic ]]
*[[Disopyramide ]]
*[[Disulfiram ]]
*[[Dorzolamide and Timolol Ophthalmic ]]
*[[Dosulepin hydrochloride]]
*[[Doxepin ]]
*Dry eye, poor tear film
*[[Duloxetine]]
*[[Enfuvirtide Injection ]]
*[[Eplerenone ]]
*[[Ergoloid Mesylates ]]
*[[Esomeprazole ]]
*[[Estazolam ]]
*[[Ethcathinone]]
*[[Ethchlorvynol]]
*[[Etodolac ]]
*[[Exenatide Injection ]]
{{ColBreak}}
*Extraocular muscle paralysis
*[[Fatigue]]
*[[Fenoprofen ]]
*[[Fexofenadine and Pseudoephedrine ]]
*[[Flavoxate ]]
*[[Flumazenil]]
*[[Fluphenazine ]]
*[[Fluticasone and Salmeterol Oral Inhalation ]]
*[[Fosamprenavir ]]
*[[Fuchs' dystrophy]]
*[[Fungal keratitis]]
*[[Furosemide ]]
*[[Gabapentin ]]
*[[Gamma-Hydroxybutyric acid]]
*[[Gatifloxacin ]]
*[[Gemfibrozil ]]
*[[Glaucoma]]
*[[Glimepiride ]]
*[[Glipizide ]]
*[[Glyburide ]]
*[[Glycopyrrolate ]]
*[[Granisetron ]]
*[[Graves ophthalmopathy]]
*[[Guanfacine]]
*[[H1 antihistamine]]
*[[Hawaiian baby woodrose]]
*[[Head trauma]]
*[[HELLP syndrome]]
*[[Henipavirus]]
*[[Homatropine]]
*[[Hwabyeong]]
*[[Hydrocortisone, Neomycin, and Polymyxin ]]
*[[Hydroxychloroquine ]]
*[[Hyoscyamine ]]
*[[Hyperbaric medicine]]
*[[Hypercoagulation]]
*[[Hyperglycemia]]
*[[Hyperopia]]
*[[Hypertension]]
*[[Hyperviscosity]]
*[[Hypervitaminosis A]]
*[[Hypoglycemia]]
*[[Imipramine ]]
*[[Indapamide ]]
*[[Indometacin]]
*[[Indomethacin ]]
*Infection, inflammation or injury of cornea
*[[Infliximab Injection ]]
*[[Insulin Aspart (rDNA Origin) Injection ]]
*Insulin lispro injection
*[[Insulinoma]]
*[[Intraocular lymphoma]]
*[[Ipratropium Oral Inhalation ]]
*[[Iritis]]
*[[Isocarboxazid ]]
*[[Isosorbide ]]
*[[Ivabradine]]
*[[Ketorolac Ophthalmic ]]
*[[Ketotifen Ophthalmic ]]
*[[Lamotrigine ]]
*[[Lanthanum ]]
*[[Levalbuterol Oral Inhalation ]]
*[[Levobupivacaine]]
*[[Lidocaine Transdermal ]]
*[[Lisinopril and Hydrochlorothiazide ]]
*[[Lodoxamide Ophthalmic ]]
*[[Lofepramine]]
*[[Lomotil]]
*[[Loprazolam]]
*[[Lorazepam ]]
*[[Loxapine Oral ]]
*[[Machado-Joseph disease]]
*[[Macular degeneration]]
*Macular disease
*[[Meclofenamate ]]
*[[Medroxyprogesterone ]]
*[[Mefenamic acid]]
*[[Megestrol ]]
*[[Meperidine ]]
*[[Metformin ]]
*[[Methocarbamol Oral ]]
*[[Methotrexate ]]
*[[Methylphenidate Transdermal ]]
*[[Metipranolol Ophthalmic ]]
*[[Miconazole Injection ]]
*[[Miglitol ]]
*[[Migraine]]
*[[Minocycline Oral ]]
*[[Minoxidil]]
*[[Moclobemide]]
*[[Monocrotophos]]
*[[Moricizine ]]
*[[Morphine Oral ]]
*[[Motofen]]
*[[Moxifloxacin ophthalmic ]]
*[[Multiple sclerosis]]
*[[Multiple endocrine neoplasia type 1]]
*[[Muscarine]]
*[[Mushroom poisoning]]
*[[Myasthenia]]
*[[Nalbuphine]]
*[[Naltrexone ]]
*[[Nateglinide oral ]]
*[[Nedocromil ophthalmic ]]
*[[Nefazodone ]]
*[[Nepafenac ophthalmic ]]
*[[Neurocardiogenic Syncope]]
*[[Neuroglycopenia]]
*[[Niacin]]
*[[Nitroglycerin ointment ]]
*[[Norethindrone ]]
*[[Nortriptyline ]]
*Ocular media opacity
*[[Oculotect]]
*[[Ofloxacin ophthalmic ]]
*[[Olanzapine ]]
{{ColBreak}}
*[[Olmesartan ]]
*[[Olopatadine ophthalmic ]]
*[[Omeprazole ]]
*[[Ondansetron injection ]]
*[[Optic neuritis]]
*[[Ornithine translocase deficiency]]
*[[Orphenadrine ]]
*[[Orthostatic hypotension]]
*[[Orthostatic intolerance]]
*[[Oxazepam ]]
*[[Oxcarbazepine]]
*[[Oxybutynin ]]
*[[Paliperidone ]]
*[[Pamidronate injection ]]
*[[Panic disorder]]
*[[Parasites]]
*[[Peginterferon alfa-2a ]]
*[[Pentamidine Isethionate Injection ]]
*[[Pergolide ]]
*[[Periphlebitis retinae]]
*[[Perphenazine oral ]]
*[[Phentermine]]
*[[Phenytoin oral ]]
*[[Pilocarpine ophthalmic ]]
*[[Pimozide ]]
*[[Pioglitazone ]]
*[[PMA]]
*[[Post-concussion syndrome]]
*[[Pralidoxime]]
*[[Prazepam ]]
*[[Prazosin and polythiazide ]]
*[[Prediabetes]]
*[[Prednisolone]]
*[[Pregabalin ]]
*[[Presbyopia]]
*[[Primaquine ]]
*[[Primidone ]]
*[[Prochlorperazine]]
*[[Procyclidine ]]
*[[Prograf]]
*Prolonged exposure to the outdoors
*[[Promethazine ]]
*[[Propafenone ]]
*[[Propantheline ]]
*[[Protriptyline ]]
*[[Pyridostigmine ]]
*[[Quetiapine ]]
*[[Quinidine Oral ]]
*[[Rasagiline ]]
*[[Refractive error]]
*[[Reiter's Syndrome]]
*[[Repaglinide ]]
*[[Retinal detachment]]
*[[Risperidone ]]
*[[Rituximab injection ]]
*[[Rivastigmine ]]
*[[Rogaine (drug)]]
*[[Ropivacaine]]
*[[Rosiglitazone ]]
*[[Salmeterol oral inhalation ]]
*[[Scopolamine]]
*Seizure disorders
*[[Sildenafil ]]
*[[Sleep deprivation]]
*[[Sodium oxybate ]]
*[[Solifenacin ]]
*[[Spironolactone ]]
*[[SSRI discontinuation syndrome]]
*[[Subdural hematoma]]
*[[Sulindac ]]
*[[Tacrolimus]]
*[[Tadalafil ]]
*[[Tamsulosin ]]
*[[Tartrazine]]
*[[Tegaserod ]]
*[[Telithromycin ]]
*[[Temazepam ]]
*[[Temik]]
*[[Temporal arteritis]]
*[[Terazosin ]]
*[[Tetrahydrozoline Ophthalmic ]]
*[[Thioridazine hydrochloride]]
*[[Thiothixene Oral ]]
*[[Thygeson's superficial punctate keratopathy]]
*[[Tiludronate ]]
*[[Tiotropium Oral Inhalation ]]
*[[Tipranavir ]]
*[[Tobramycin Ophthalmic ]]
*[[Tolazamide ]]
*[[Tolbutamide ]]
*[[Topiramate]]
*[[Trachoma]]
*[[Tranylcypromine ]]
*[[Traumatic brain injury]]
*[[Travoprost Ophthalmic ]]
*[[Trazodone ]]
*[[Triazolam ]]
*[[Tricyclic antidepressant]]
*[[Trifluoperazine Oral ]]
*[[Trihexyphenidyl ]]
*[[Trimethobenzamide ]]
*[[Trimipramine ]]
*[[Tropicamide]]
*[[Trospium ]]
*[[Uveitis]]
*[[Valproic Acid ]]
*[[Vardenafil ]]
*Vasculopathy
*[[Vertebrobasilar insufficiency]]
*[[Verteporfin]]
*[[Viral]]
*[[Voriconazole ]]
*[[Vorinostat ]]
*[[Ziprasidone ]]
*[[Zolpidem ]]
*[[Zopiclone]]
{{EndMultiCol}}


==Differentiating blurred vision from other diseases==
OR


==Epidemiology and Demographics==
[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
 
 
[Disease name] affects men and women equally.
 
OR
 
[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.
 
 
The majority of [disease name] cases are reported in [geographical region].
 
OR


[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
==Risk Factors==
==Risk Factors==
There are no established risk factors for [disease name].
OR
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
OR


Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
==Screening==
==Screening==
There is insufficient evidence to recommend routine screening for [disease/malignancy].


OR
According to the [guideline name], screening for [disease name] is not recommended.
OR
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].
==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].


OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
==Diagnosis==
==Diagnosis==
===Diagnosis Study of Choice===
===Diagnostic Study of Choice===
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
 
OR
 
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
 
OR
 
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
 
OR


There are no established criteria for the diagnosis of [disease name].
===History and Symptoms===
===History and Symptoms===
The majority of patients with [disease name] are asymptomatic.


*Detailed history important, including the following:
OR
*:*Progression of symptoms
*:*Duration of symptoms
*:*Near or farsighted
*:*Binocular or uniocular
*:*Permanent or transient
*Associated symptoms
*Past medical history


The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
===Physical Examination===
===Physical Examination===
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].
OR
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
The presence of [finding(s)] on physical examination is diagnostic of [disease name].
OR
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].
===Laboratory Findings===
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR


====Eyes====
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].


*Complete ophthalmologic exam including:
OR
*:*Dilated fundus exam
*:*Slit-lamp examination
*:*Visual acuity
*:*Dry or irritated eyes
*:*Improvement of vision with pinhole


====Ear Nose and Throat====
[Test] is usually normal among patients with [disease name].
For ENT palpate the temporal area to determine if there is a pain in the temporal area to suggest [[temporal arteritis]]


*Neurologic exam if necessary
OR


===Laboratory Findings===
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].


*[[Complete blood count]] ([[CBC]])
OR
*Random or fasting [[blood sugar]]
*:*Repeat [[glucose]] (if initial [[glucose]] is elevated)
*[[Partial thromboplastin time]] (PTT)
*[[Prothrombin time]] (PT)
*[[Erythrocyte sedimentation rate]] is very important to rule out [[temporal arteritis]]


There are no diagnostic laboratory findings associated with [disease name].
===Electrocardiogram===
===Electrocardiogram===
There are no ECG findings associated with [disease name].
OR


An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
===X-ray===
===X-ray===
There are no x-ray findings associated with [disease name].
OR


An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
===Echocardiography or Ultrasound===
===Echocardiography or Ultrasound===
There are no echocardiography/ultrasound  findings associated with [disease name].


OR
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
===CT scan===
===CT scan===
There are no CT scan findings associated with [disease name].
OR
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].


OR
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
===MRI===
===MRI===
There are no MRI findings associated with [disease name].


OR
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
===Other Imaging Findings===
===Other Imaging Findings===
There are no other imaging findings associated with [disease name].


OR
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
===Other Diagnostic Studies===
===Other Diagnostic Studies===
There are no other diagnostic studies associated with [disease name].
OR
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR


Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].
==Treatment==
==Treatment==
===Medical Therapy===
There is no treatment for [disease name]; the mainstay of therapy is supportive care.


===Medical Therapy===
OR


*Treat underlying pathologies
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].
*For dry eyes, lubrication
*Appropriate treatment for hyperviscosity
*Antiseizure prophylaxis (seizure disorders)


OR
The majority of cases of [disease name] are self-limited and require only supportive care.
OR
[Disease name] is a medical emergency and requires prompt treatment.
OR
The mainstay of treatment for [disease name] is [therapy].
OR The optimal therapy for [malignancy name] depends on the stage at diagnosis.
OR
[Therapy] is recommended among all patients who develop [disease name].
OR
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].
OR
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
OR
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].
OR
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].
===Surgery===
===Surgery===
Surgical intervention is not recommended for the management of [disease name].
OR
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]


*Glasses or contact lenses for blurred vision due to refractive errors
OR
*Possible surgical repair for retinal detachment
*Temporal artery biopsy may be needed


The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].
OR
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.
OR
Surgery is the mainstay of treatment for [disease or malignancy].
===Primary Prevention===
===Primary Prevention===
There are no established measures for the primary prevention of [disease name].


OR
There are no available vaccines against [disease name].
OR
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
OR
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].
===Secondary Prevention===
===Secondary Prevention===
There are no established measures for the secondary prevention of [disease name].
OR


Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 00:31, 27 January 2021


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief:

Overview

Historical Perspective

[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].

The association between [important risk factor/cause] and [disease name] was made in/during [year/event].

In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].

In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

There have been several outbreaks of [disease name], including -----.

In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

Classification

There is no established system for the classification of [disease name].

OR

[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].

OR

[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].

OR

Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.

OR

If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].

OR

The staging of [malignancy name] is based on the [staging system].

OR

There is no established system for the staging of [malignancy name].

Pathophysiology

The exact pathogenesis of [disease name] is not fully understood.

OR

It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].

OR

[Pathogen name] is usually transmitted via the [transmission route] route to the human host.

OR

Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.

OR


[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].

OR

The progression to [disease name] usually involves the [molecular pathway].

OR

The pathophysiology of [disease/malignancy] depends on the histological subtype.

Causes

Disease name] may be caused by [cause1], [cause2], or [cause3].

OR

Common causes of [disease] include [cause1], [cause2], and [cause3].

OR

The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].

OR

The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.

Differentiating ((Page name)) from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Epidemiology and Demographics

The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.

OR

In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.

OR

In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate of [number range]%.


Patients of all age groups may develop [disease name].

OR

The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.

OR

[Disease name] commonly affects individuals younger than/older than [number of years] years of age.

OR

[Chronic disease name] is usually first diagnosed among [age group].

OR

[Acute disease name] commonly affects [age group].


There is no racial predilection to [disease name].

OR

[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].


[Disease name] affects men and women equally.

OR

[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.


The majority of [disease name] cases are reported in [geographical region].

OR

[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].

Risk Factors

There are no established risk factors for [disease name].

OR

The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.

Screening

There is insufficient evidence to recommend routine screening for [disease/malignancy].

OR

According to the [guideline name], screening for [disease name] is not recommended.

OR

According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].

Natural History, Complications, and Prognosis

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Diagnosis

Diagnostic Study of Choice

The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].

OR

The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].

OR

The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].

OR

There are no established criteria for the diagnosis of [disease name].

History and Symptoms

The majority of patients with [disease name] are asymptomatic.

OR

The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

Physical Examination

Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].

OR

Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

The presence of [finding(s)] on physical examination is diagnostic of [disease name].

OR

The presence of [finding(s)] on physical examination is highly suggestive of [disease name].

Laboratory Findings

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Electrocardiogram

There are no ECG findings associated with [disease name].

OR

An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

X-ray

There are no x-ray findings associated with [disease name].

OR

An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].

Echocardiography or Ultrasound

There are no echocardiography/ultrasound findings associated with [disease name].

OR

Echocardiography/ultrasound may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

There are no echocardiography/ultrasound findings associated with [disease name]. However, an echocardiography/ultrasound may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].

CT scan

There are no CT scan findings associated with [disease name].

OR

[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].

MRI

There are no MRI findings associated with [disease name].

OR

[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].

Other Imaging Findings

There are no other imaging findings associated with [disease name].

OR

[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

There are no other diagnostic studies associated with [disease name].

OR

[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

There is no treatment for [disease name]; the mainstay of therapy is supportive care.

OR

Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].

OR

The majority of cases of [disease name] are self-limited and require only supportive care.

OR

[Disease name] is a medical emergency and requires prompt treatment.

OR

The mainstay of treatment for [disease name] is [therapy].

OR The optimal therapy for [malignancy name] depends on the stage at diagnosis.

OR

[Therapy] is recommended among all patients who develop [disease name].

OR

Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].

OR

Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].

OR

Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].

OR

Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].

Surgery

Surgical intervention is not recommended for the management of [disease name].

OR

Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]

OR

The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].

OR

The feasibility of surgery depends on the stage of [malignancy] at diagnosis.

OR

Surgery is the mainstay of treatment for [disease or malignancy].

Primary Prevention

There are no established measures for the primary prevention of [disease name].

OR

There are no available vaccines against [disease name].

OR

Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].

OR

[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].

Secondary Prevention

There are no established measures for the secondary prevention of [disease name].

OR

Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].

References


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