Biotin deficiency

Revision as of 19:14, 29 May 2009 by Brian Blank (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Biotin deficiency
Error creating thumbnail: File missing
Biotin
ICD-10 E53.8
ICD-9 266.2
eMedicine ped/238 

WikiDoc Resources for Biotin deficiency

Articles

Most recent articles on Biotin deficiency

Most cited articles on Biotin deficiency

Review articles on Biotin deficiency

Articles on Biotin deficiency in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Biotin deficiency

Images of Biotin deficiency

Photos of Biotin deficiency

Podcasts & MP3s on Biotin deficiency

Videos on Biotin deficiency

Evidence Based Medicine

Cochrane Collaboration on Biotin deficiency

Bandolier on Biotin deficiency

TRIP on Biotin deficiency

Clinical Trials

Ongoing Trials on Biotin deficiency at Clinical Trials.gov

Trial results on Biotin deficiency

Clinical Trials on Biotin deficiency at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Biotin deficiency

NICE Guidance on Biotin deficiency

NHS PRODIGY Guidance

FDA on Biotin deficiency

CDC on Biotin deficiency

Books

Books on Biotin deficiency

News

Biotin deficiency in the news

Be alerted to news on Biotin deficiency

News trends on Biotin deficiency

Commentary

Blogs on Biotin deficiency

Definitions

Definitions of Biotin deficiency

Patient Resources / Community

Patient resources on Biotin deficiency

Discussion groups on Biotin deficiency

Patient Handouts on Biotin deficiency

Directions to Hospitals Treating Biotin deficiency

Risk calculators and risk factors for Biotin deficiency

Healthcare Provider Resources

Symptoms of Biotin deficiency

Causes & Risk Factors for Biotin deficiency

Diagnostic studies for Biotin deficiency

Treatment of Biotin deficiency

Continuing Medical Education (CME)

CME Programs on Biotin deficiency

International

Biotin deficiency en Espanol

Biotin deficiency en Francais

Business

Biotin deficiency in the Marketplace

Patents on Biotin deficiency

Experimental / Informatics

List of terms related to Biotin deficiency

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Biotin deficiency can have a very serious, even fatal, outcome if it is allowed to progress without treatment. Signs and symptoms of biotin deficiency can develop in persons of any age, race, or gender. Biotin deficiency rarely occurs in healthy individuals, since the daily requirements of biotin are low, many foods contain adequate amounts, intestinal bacteria synthesize small amounts, and the body effectively scavenges and recycles biotin from bodily waste. However, deficiency can be caused by excessive consumption of raw egg-whites over a long period (months to years). Egg-whites contain high levels of avidin, a protein that binds biotin strongly. Once a biotin-avidin complex forms, the bond is essentially irreversible. The biotin-avidin complex is not broken down nor liberated during digestion, and the biotin-avidin complex is lost in the feces. Once cooked, the egg-white avidin becomes denatured and entirely non-toxic.

Initial symptoms of biotin deficiency include:

  1. Dry skin
  2. Seborrheic dermatitis
  3. Fungal infections
  4. Rashes including erythematous periorofacial macular rash
  5. Fine and brittle hair
  6. Hair loss or total alopecia

If left untreated, neurological symptoms can develop, including:

  1. Mild depression, which may progress to profound lassitude and, eventually, to somnolence
  2. Changes in mental status
  3. Generalized muscular pains (myalgias)
  4. Hyperesthesias and paresthesias

The treatment for biotin deficiency is simply to start taking some biotin supplements.

Biotin deficiency

Biotin deficiency should not be confused with biotinidase deficiency, which is not due to inadequate biotin, but rather to a deficiency in the enzymes which process it.

Template:SIB Template:Nutritional pathology


Template:WikiDoc Sources