Biotin: Difference between revisions

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{{Chembox new
{{DrugProjectFormSinglePage
|   Name = Biotin
|authorTag={{Ammu}}
|   ImageFile = Biotin structure.svg
|genericName=Biotin
|   ImageFile1 = Biotin3d.png
|aOrAn=a
|   OtherNames = Vitamin B<sub>7</sub>; Vitamin H
|drugClass=[[vitamin]]
| Section2 = {{Chembox Properties
|indicationType=treatment
|   Formula = C<sub>10</sub>H<sub>16</sub>N<sub>2</sub>O<sub>3</sub>S
|indication=to strengthen the [[hair]] follicle and prevents hair loss as well. It is nutrient for the [[hair]] root and helps oxygenate the [[hair]] turn slowing the loss and provides resilience and resistence to [[hair]]
|   MolarMass = 244.31 g/mol
|adverseReactions=[[gastrointestinal upset]], administration of [[anticonvulsant]] medications may impair biotin absorption
|   Solubility = Soluble}}
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
}}
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
{{SI}}
 
* Content
 
<!--Adult Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult=* Biotin is a major component of the formulation acts to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss. Provides resilience and resistence to hair.
*  Apply amount of the hair follicle and massage until absorbed. Use every 12 hours for the fast and sustained effect.
* Suitable for children, adolescents, adults and seniors.
|offLabelAdultGuideSupport=* BIOTINIDASE DEFICIENCY, oral: 10 to 40 milligrams daily
* BRITTLE NAILS, oral, tablet: 2.5 milligrams daily
* CARBOXYLASE DEFICIENCY, intravenous, solution: 18.4 micromoles daily
* HOLOCARBOXYLASE DEFICIENCY IN PREGNANCY, oral: 10 milligrams daily
* PARENTERAL ALIMENTATION-INDUCED DEFICIENCY, oral, solution or tablet: 0.1 to 1 milligram daily
* RECOMMENDED DIETARY ALLOWANCE (RDA), oral: 30 to 100 micrograms daily
* VAGINAL CANDIDIASIS, oral: 20 milligrams daily
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
|fdaLIADPed=There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Off-Label Use and Dosage (Pediatric)-->
 
<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport=* [[ALOPECIA AREATA]], oral: 20 milligrams daily with oral zinc aspartate 100 milligrams and topical clobetasol propionate 0.025%
* BASAL-GANGLIA DISEASE, BIOTIN-responsive, oral or solution: 5 to 10 milligrams/kilogram daily
* BETA-METHYLCROTONYL-GLYCINURIA, solution, oral: 10 milligrams daily
* BIOTINIDASE DEFICIENCY, solution or tablet, oral: 6 to 40 milligrams daily
* PARENTERAL ALIMENTATION-INDUCED DEFICIENCY, solution or tablet, oral: 0.1 to 1 milligram daily
* PARTIAL BIOTINIDASE DEFICIENCY, solution or tablet: 5 to 10 milligrams daily or less.
* PROTEIN-ENERGY MALNUTRITION, solution or tablet, oral: BIOTIN 10 milligrams daily along with standard treatment for malnutrition
* PYRUVATE-CARBOXYLASE DEFICIENCY, solution or tablet, oral: BIOTIN 10 milligrams (mg) daily, thiamine 80 mg daily, pyridoxine 300 mg daily
* RECOMMENDED DIETARY ALLOWANCE, oral, diet or tablet: 50 micrograms daily
* UNCOMBABLE HAIR SYNDROME, solution or tablet, oral: 0.9 milligram daily in three divided doses
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Contraindications-->
|contraindications=* Hypersensitivity to Biotin
|warnings=This product is for topical application, if this product to contact with eyes rinse immediately with water and consult your doctor.
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
|postmarketing=* Gastrointestinal upset
* Administration of anticonvulsant medications may impair Biotin absorption
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.


<!--Administration and Monitoring-->
|administration=* [[Oral]]
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


:''Vitamin H redirects here.  In medical slang, Vitamin H may also refer to [[haloperidol]].''


'''Biotin''', also known as [[vitamin]] H or B<sub><small>7</small></sub>, has the chemical formula C<sub>10</sub>H<sub>16</sub>N<sub>2</sub>O<sub>3</sub>S (Biotin; Coenzyme R, Biopeiderm), is a water-soluble B-complex vitamin which is composed of an ureido (tetrahydroimidizalone) ring fused with a [[tetrahydrothiophene]] ring. A [[valeric acid]] substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring.  Biotin is important in the [[catalysis]] of essential metabolic reactions to synthesize [[fatty acid]]s, in [[gluconeogenesis]], and to metabolize [[leucine]].
==General overview==
Biotin is used in cell growth, the production of fatty acids and in the metabolism of fats and amino acids. It plays a role in the [[Citric acid cycle]], which is the process by which biochemical energy is generated during [[Cellular respiration|aerobic respiration]].
Biotin not only assists in various metabolic chemical conversions, but also helps to transfer carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level.  Biotin is often recommended for strengthening hair and nails.  Consequently, it is found in many cosmetic and health products for the hair and skin.


Deficiency is extremely rare, as intestinal bacteria generally produce in excess of the body's daily requirement. For that reason, statutory agencies in many countries (e.g., the Australian Department of Health and Aging) do not prescribe a recommended daily intake.
<!--IV Compatibility-->
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.


==Uses==
<!--Overdosage-->
===Hair problems===
|overdose=There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.
Biotin supplements are often recommended as a natural product to counteract the problem of hair loss in both children and adults.  There are, however, no studies that show any benefit in any case where the subject is not actually biotin deficient.  The signs and symptoms of biotin deficiency include hair loss which progresses in severity to include loss of eye lashes and eye brows in severely deficient subjects.  Some shampoos are available that contain biotin, but it is doubtful whether they would have any useful effect, as biotin is not absorbed well through the skin.


===[[Cradle cap]] (seborrheic dermatitis)===
<!--Pharmacology-->
Children with a rare inherited metabolic disorder called [[phenylketonuria]] (PKU; in which one is unable to break down the amino acid phenylalanine) often develop skin conditions such as [[eczema]] and [[seborrheic dermatitis]] in areas of the body other than the scalp. The scaly skin changes that occur in people with PKU may be related to poor ability to use biotin. Increasing dietary biotin has been known to improve [[seborrheic dermatitis]] in these cases.


===Diabetes===
<!--Drug box 2-->
People  with type 2 [[diabetes]] often have low levels of biotin. Biotin may be involved in the synthesis and release of insulin. Preliminary studies in both animals and people suggest that biotin may help improve blood sugar control in those with diabetes, particularly type 2 diabetes.<ref>{{cite journal |last= Campbell |first= R. Keith |year=2006 |month= Nov |title= A Critical Review of Chromium Picolinate and Biotin |journal=U.S. Pharmacist |volume= 31|issue= 11 |url= http://www.uspharmacist.com/index.asp?show=article&page=8_1895.htm  }}</ref>
|drugBox={{chembox2
| Watchedfields = changed
| verifiedrevid = 443307462
| Name = Biotin
| Reference =<ref>''[[Merck Index]]'', 11th Edition, '''1244'''.</ref>
| ImageFile = Biotin_structure.png
| ImageSize =
| ImageFile1 = Biotin-3D-balls.png
| ImageSize1 =
| ImageFile2 = Biotin_ball-and-stick_animation.gif
| ImageSize2 =
| IUPACName =5-[(3a''S'',4''S'',6a''R'')-2-oxohexahydro-1''H''-thieno[3,4-''d'']imidazol-4-yl]pentanoic acid
| OtherNames = Vitamin B<sub>7</sub>; Vitamin H; Coenzyme R; Biopeiderm
|Section1={{Chembox Identifiers
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00121
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 15956
| SMILES = O=C1N[C@@H]2[C@@H](SC[C@@H]2N1)CCCCC(=O)O
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6SO6U10H04
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00029
| InChI = 1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
| InChIKey = YBJHBAHKTGYVGT-ZKWXMUAHBB
| SMILES1 = C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 857
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = YBJHBAHKTGYVGT-ZKWXMUAHSA-N
| CASNo = 58-85-5
| CASNo_Ref = {{cascite|correct|CAS}}
| PubChem = 171548
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 149962
| RTECS =
| ATCCode_prefix = A11
| ATCCode_suffix = HA05
  }}
|Section2={{Chembox Properties
| C =10|H=16|N=2|O=3|S=1
| Appearance = White crystalline needles
| Solubility = 22 mg/100 mL
| MeltingPtC = 232 to 233
| Melting_notes =
}}
|Section3={{Chembox Hazards
| NFPA-H = 1
| NFPA-F = 1
| NFPA-R = 0
}}
}}
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.


==Deficiency==
<!--Pharmacokinetics-->
[[Biotin deficiency]] is relatively rare and mild, and can be addressed with supplementation. Such deficiency can be caused by the excessive consumption of raw [[egg white]]s, which contain high levels of the protein [[avidin]], which binds biotin strongly.
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.


[[Biotinidase deficiency]] is not due to inadequate biotin, but rather to a deficiency in the enzymes which process it.
<!--Nonclinical Toxicology-->
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.


==Biochemistry==
<!--Clinical Studies-->
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.


Biotin is a [[Cofactor (biochemistry)|cofactor]] responsible for [[carbon dioxide]] transfer in several [[carboxylase]] [[enzyme]]s:
<!--How Supplied-->
|howSupplied=*


* [[Acetyl-CoA carboxylase]] alpha
<!--Patient Counseling Information-->
* [[Acetyl-CoA carboxylase]] beta
|packLabel=[[File:Biotin 1.jpg|thumb|none|400px|This image is provided by the National Library of Medicine.]]
* [[Methylcrotonyl-CoA carboxylase]]
[[File:Biotin 2.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]
* [[Propionyl-CoA carboxylase]]
[[File:Biotin 3.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]
* [[Pyruvate carboxylase]]
[[File:Biotin 4.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.


The attachment of biotin to various chemical sites, called [[biotinylation]], can be used as an important laboratory technique to study various processes including protein localization, [[protein-protein interaction|protein interactions]], [[DNA]] [[transcription (genetics)|transcription]] and [[DNA replication|replication]]. Biotin itself is known to biotinylate histones, but is not found naturally on DNA.  [[Holocarboxylase synthetase]] is involved in the binding of biotin.
<!--Precautions with Alcohol-->
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.


Biotin binds very tightly to the tetrameric protein [[avidin]] (also [[streptavidin]] and [[neutravidin]]), with a [[dissociation constant]] ''K''<sub>d</sub> in the order of 10<sup>-15</sup> mol/L (Bonjour, 1977; Green 1975; and Roth, 1985). This is often used in different biotechnological applications. Until [[2005]], very harsh conditions were required to break the biotin-streptavidin bond.<ref>{{cite journal |author=Holmberg A, Blomstergren A, Nord O et al. |title=The biotin-streptavidin interaction can be reversibly broken using water at elevated temperatures |journal=Electrophoresis |volume=26 |issue=3 |pages=501-10 |year=2005 |pmid=15690449 |doi=10.1002/elps.200410070}}</ref>
<!--Brand Names-->
|brandNames=*  BIONA-VIT ®<ref>{{Cite web | title = BIONA-VIT CONTROLS AND PREVENTS HAIR LOSS- biotin liquid | url =http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=91c7caea-b234-49c0-a55f-02d14d888130  }}</ref>


==Laboratory uses==
<!--Look-Alike Drug Names-->
In the biology laboratory, biotin is sometimes chemically linked, or tagged, to a molecule or protein for biochemical assays. This process is called [[biotinylation]]. Since avidins bind preferentially to biotin, biotin-tagged molecules can be extracted from a sample by mixing them with beads with covalently-attached avidin, and washing away anything unbound to the beads.
|drugShortage=
}}
<!--Pill Image-->


For example, biotin can be attached to a molecule of interest (e.g. a protein), and this modified molecule will be mixed with a complex mixture of proteins.  Avidin or streptavidin beads are added to the mixture, and the biotinylated molecule will bind to the beads.  Any other proteins binding to the biotinylated molecule will also stay with the beads.  All other unbound proteins can be washed away, and the scientist can use a variety of methods to determine which proteins have bound to the biotinylated molecule.


Biotinylated antibodies are used to capture avidin or streptavidin in both the [[ELISPOT]] and [[ELISA]] techniques.


==References==
<!--Label Display Image-->
<references/>


==See also==
* [[Biotinylation]]
* [[Avidin]]
* [[Streptavidin]]
* [[Neutravidin]]


==External links==
* {{pauling|id=vitamins/biotin|title=Biotin|author=Jane Higdon}}
*[http://www.al-hikmah.org/biotin.asp Biotin - Biocytin (Brewer's YeastBiotin Complex)]


{{Vitamin}}


[[Category:Vitamins]]
[[Category:Organosulfur compounds]]
[[Category:Coenzymes]]


[[ar:فيتامين بي7]]
<!--Category-->
[[cs:Vitamín H]]
[[de:Biotin]]
[[et:Biotiin]]
[[es:Biotina]]
[[fr:Vitamine B8]]
[[gl:Vitamina B7]]
[[ko:바이오틴]]
[[hr:Biotin]]
[[it:Biotina]]
[[he:ביוטין]]
[[lb:Biotin]]
[[lt:Biotinas]]
[[nl:Biotine]]
[[ja:ビオチン]]
[[pl:Biotyna]]
[[pt:Biotina]]
[[ru:Биотин]]
[[sk:Biotín]]
[[sr:Витамин Х]]
[[sh:Biotin]]
[[su:Biotin]]
[[fi:Biotiini]]
[[sv:Biotin]]
[[tr:Biyotin]]
[[uk:Біотин]]
[[zh:生物素]]


{{WH}}
[[Category:Drug]]
{{WS}}
{{jb1}}

Latest revision as of 18:10, 18 August 2015

Biotin
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Biotin is a vitamin that is FDA approved for the treatment of to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss and provides resilience and resistence to hair. Common adverse reactions include gastrointestinal upset, administration of anticonvulsant medications may impair biotin absorption.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Biotin is a major component of the formulation acts to strengthen the hair follicle and prevents hair loss as well. It is nutrient for the hair root and helps oxygenate the hair turn slowing the loss. Provides resilience and resistence to hair.
  • Apply amount of the hair follicle and massage until absorbed. Use every 12 hours for the fast and sustained effect.
  • Suitable for children, adolescents, adults and seniors.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

  • BIOTINIDASE DEFICIENCY, oral: 10 to 40 milligrams daily
  • BRITTLE NAILS, oral, tablet: 2.5 milligrams daily
  • CARBOXYLASE DEFICIENCY, intravenous, solution: 18.4 micromoles daily
  • HOLOCARBOXYLASE DEFICIENCY IN PREGNANCY, oral: 10 milligrams daily
  • PARENTERAL ALIMENTATION-INDUCED DEFICIENCY, oral, solution or tablet: 0.1 to 1 milligram daily
  • RECOMMENDED DIETARY ALLOWANCE (RDA), oral: 30 to 100 micrograms daily
  • VAGINAL CANDIDIASIS, oral: 20 milligrams daily

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Biotin in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Biotin in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

  • ALOPECIA AREATA, oral: 20 milligrams daily with oral zinc aspartate 100 milligrams and topical clobetasol propionate 0.025%
  • BASAL-GANGLIA DISEASE, BIOTIN-responsive, oral or solution: 5 to 10 milligrams/kilogram daily
  • BETA-METHYLCROTONYL-GLYCINURIA, solution, oral: 10 milligrams daily
  • BIOTINIDASE DEFICIENCY, solution or tablet, oral: 6 to 40 milligrams daily
  • PARENTERAL ALIMENTATION-INDUCED DEFICIENCY, solution or tablet, oral: 0.1 to 1 milligram daily
  • PARTIAL BIOTINIDASE DEFICIENCY, solution or tablet: 5 to 10 milligrams daily or less.
  • PROTEIN-ENERGY MALNUTRITION, solution or tablet, oral: BIOTIN 10 milligrams daily along with standard treatment for malnutrition
  • PYRUVATE-CARBOXYLASE DEFICIENCY, solution or tablet, oral: BIOTIN 10 milligrams (mg) daily, thiamine 80 mg daily, pyridoxine 300 mg daily
  • RECOMMENDED DIETARY ALLOWANCE, oral, diet or tablet: 50 micrograms daily
  • UNCOMBABLE HAIR SYNDROME, solution or tablet, oral: 0.9 milligram daily in three divided doses

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Biotin in pediatric patients.

Contraindications

  • Hypersensitivity to Biotin

Warnings

This product is for topical application, if this product to contact with eyes rinse immediately with water and consult your doctor.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Biotin in the drug label.

Postmarketing Experience

  • Gastrointestinal upset
  • Administration of anticonvulsant medications may impair Biotin absorption

Drug Interactions

There is limited information regarding Biotin Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Biotin in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Biotin during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Biotin with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Biotin with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Biotin with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Biotin with respect to specific gender populations.

Race

There is no FDA guidance on the use of Biotin with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Biotin in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Biotin in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Biotin in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Biotin in patients who are immunocompromised.

Administration and Monitoring

Administration

Monitoring

There is limited information regarding Monitoring of Biotin in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Biotin in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Biotin in the drug label.

Pharmacology

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Template:Chembox header2 | Biotin[1]
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
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KEGG
UNII
Properties
C10H16N2O3S
Molar mass 244.31 g·mol−1
Hazards
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Biotin Mechanism of Action in the drug label.

Structure

There is limited information regarding Biotin Structure in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Biotin in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Biotin in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Biotin in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Biotin in the drug label.

How Supplied

Storage

There is limited information regarding Biotin Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Biotin |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

This image is provided by the National Library of Medicine.
This image is provided by the National Library of Medicine.
This image is provided by the National Library of Medicine.
This image is provided by the National Library of Medicine.

{{#ask: Label Page::Biotin |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Biotin in the drug label.

Precautions with Alcohol

  • Alcohol-Biotin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • BIONA-VIT ®[2]

Look-Alike Drug Names

There is limited information regarding Biotin Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Merck Index, 11th Edition, 1244.
  2. ↑ "BIONA-VIT CONTROLS AND PREVENTS HAIR LOSS- biotin liquid".
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