Beriberi differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Differential Diagnosis

Beriberi should be differentiated from other causes of cardiac dysfunction (wet beriberi), peripheral neuropathy (dry beriberi), delirium (WKS), and other disorders caused by excessive alcohol drinking. However, the differential diagnosis is broad due to the non-specific symptoms of cardiac and neural involvement associated with the condition.

Disorders Etiology Clinical Presentation Laboratory findings
Cardiomyopathy due to other causes as alcohol or DM
Delirium and delusional disorders
Depression
Nerve entrapment disorders
  • Poor appetite
  • Fatigue
  • Emesis
  • Low grade fever
  • Abdominal tenderness
Alcoholic hepatitis
Diabetic ketoacidosis
Hyperthyroidism
  • Primary: Grave's disease, toxic thyroid nodules and adenoma
  • Secondary: Pituitary adenomas and intracranial tumors
  • Tertiary:Intracranial tumors involving the hypothalamus
  • Elevated T3 and T4 hormones
  • TSH: Reduced in 1ry and Elevated in 2ry hyperthyroidism.
  • Thyroid stimulating antibodies: Elevated only in Grave's disease
Folic acid deficiency

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