B-cell prolymphocytic leukemia overview

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B-cell prolymphocytic leukemia

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating B-cell prolymphocytic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Biopsy

X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]

Synonyms and keywords: B-PLL, Prolymphocytic leukemia, B-cell type

Overview

B-cell prolymphocytic leukemia is a form of leukemia or cancer of the white blood cells

Historical Perspective

Classification

Pathophysiology

B-cell prolymphocytic leukemia arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies.

Differentiating B-cell prolymphocytic leukemia from other Diseases

B-cell prolymphocytic leukemia must be differentiated from other diseases such as T-cell prolymphocytic leukemia, chronic lymphocytic leukemia and hairy cell leukemia.

Epidemiology and Demographics

The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally.

Risk Factors

Screening

Natural History, Complications and Prognosis

The prognosis for B-cell prolymphocytic leukemia is generally poor.

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

References