B-cell prolymphocytic leukemia pathophysiology
B-cell prolymphocytic leukemia
B-cell prolymphocytic leukemia pathophysiology On the Web
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B-cell prolymphocytic leukemia arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies.
- B-cell prolymphocytic leukemia cells are positive for B cell markers such as CD19, CD20, CD22.
- CD23 is negative but CD5 is expressed in one third tumor cells population.
- Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7
- Tumor cells express surface IgM proteins.
- The originating cell line for B-cell prolymphocytic leukemia is a mature B-cells and are medium sized cells.
- More than 50 percent of the circulating cells in the peripheral blood are prolymphocytes.
- The nucleus is typically round or oval, and the cytoplasm is usually moderately abundant.
- Leukemic cells can be found in peripheral blood, lymph nodes, bone marrow, spleen, liver, and skin.
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