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	B-cell prolymphocytic leukemia
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Revision as of 16:05, 5 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]

Synonyms and keywords: B-PLL

Differentiating B-cell prolymphocytic leukemia from other Diseases

Natural History, Complications and Prognosis

Overview

B-cell prolymphocytic leukemia is a more aggressive but still treatable form of leukemia. The malignant B cells are larger than average.

Diagnosis exam

Blood chemistry studies
Bone marrow aspiration and biopsy
Complete blood count (CBC)
CT (CAT) scan
Cytogenetic analysis
Immunophenotyping
Peripheral blood smear
Physical exam and history (H&P)

Stem cell trasplant

A stem cell transplant is sometimes used to treat people with aggressive prolymphocytic leukemia. Many people with prolymphocytic leukemia are older or may not be in good health, so a stem cell trasplant is often not a suitable option for them. However, it may be an effective option for younger people with prolymphocytic leukemia.

References

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@@ Line 26: / Line 26: @@
 ==Overview==
 '''B-cell prolymphocytic leukemia''' is a more aggressive but still treatable form of [[leukemia]]. The malignant [[B cells]] are larger than average.
-==Prognosis==
-It has a relatively poor prognosis.<ref name="pmid16642047">{{cite journal |author=Del Giudice I, Davis Z, Matutes E, ''et al'' |title=IgVH genes mutation and usage, [[ZAP-70]] and [[CD38]] expression provide new insights on B-cell prolymphocytic leukemia (B-PLL) |journal=Leukemia |volume=20 |issue=7 |pages=1231-7 |year=2006 |pmid=16642047 |doi=10.1038/sj.leu.2404238}}</ref>. But usually has a better prognosis than T-cell prolymphocytic leukemia.<ref name=T-PLL>{{cite web | title = Canadian Cancer Society| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/prolymphocytic-leukemias/?region=on }}</ref>
-==Symptoms==
-* [[Anemia]]<ref name=B-PLL>{{cite web | title = National cancer institute| url = http://seer.cancer.gov/seertools/hemelymph/51f6cf58e3e27c3994bd53f9/ }}</ref>
-* Massive splenomegaly
-* Rapidly rising lymphocyte count
-* [[Thrombocytopenia]]
-* Peripheral lymphadenopathy (minimal)
-==Differential diagnosis==
-* [[Hairy cell leukemia]]<ref name="pmid19110524">{{cite journal |author=Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S |title=Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia |journal=Rinsho Ketsueki |volume=49 |issue=12 |pages=1619–22 |date=December 2008 |pmid=19110524 |doi=10.11406/rinketsu.49.1619}}</ref>
-* [[Waldenström macroglobulinemia]]<ref name="pmid19110524">{{cite journal |author=Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S |title=Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia |journal=Rinsho Ketsueki |volume=49 |issue=12 |pages=1619–22 |date=December 2008 |pmid=19110524 |doi=10.11406/rinketsu.49.1619}}</ref>
@@ Line 52: / Line 38: @@
 *Peripheral blood smear
 *Physical exam and history (H&P)
-==Treatment==
-B-cell prolymphocytic leukemia responds better when combinations of [[chemotherapy]] drugs are used. Some combinations that may be used are:<ref name=T-PLL>{{cite web | title = Canadian Cancer Society| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/prolymphocytic-leukemias/?region=on }}</ref>
-* CVP – [[Cyclophosphamide]], [[vincristine]] and [[prednisone]].
-* CHOP – [[Cyclophosphamide]], [[doxorubicin]], [[vincristine]] and [[prednisone]].
-Other chemotherapy drugs (purine analogues) are often used to treat T-cell prolymphocytic leukemia are:
-* [[Fludarabine]]
-* [[Cladribine]]
-* [[Pentostatin]]
-===Biological therapy===
-Monoclonal antibodies are a type of [[biological therapy]] that has been effective in treating certain types of [[leukemias]]. These drugs may be used alone or in combination with chemotherapy to treat prolymphocytic leukemia.
-* [[Alemtuzumab]] seems to be particularly effective in treating T-cell prolymphocytic leukemia. It may be used in people whose [[lymphoma]] is no longer responding to chemotherapy drugs like [[fludarabine]].
-===Splenectomy or radiation therapy to the spleen===
-[[Splenectomy]] and external beam radiation therapy to the spleen may be used in some people with Prolymphocytic leukemia.
 ===Stem cell trasplant===

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy