Axotomy: Difference between revisions
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | |||
{{CMG}} | |||
==Overview== | |||
The process of cutting or to otherwise sever an [[axon]]. Derived from axo- (=axon) and -tomy (=surgery). This type of denervation is often used in experimental studies on neuronal physiology and neuronal death or survival as a method to better understand [[ICD-10 Chapter VI: Diseases of the nervous system|nervous system diseases]].<ref name="MedDictionary">[http://cancerweb.ncl.ac.uk/cgi-bin/omd?axotomy "Online Medical Dictionary"]</ref> | The process of cutting or to otherwise sever an [[axon]]. Derived from axo- (=axon) and -tomy (=surgery). This type of denervation is often used in experimental studies on neuronal physiology and neuronal death or survival as a method to better understand [[ICD-10 Chapter VI: Diseases of the nervous system|nervous system diseases]].<ref name="MedDictionary">[http://cancerweb.ncl.ac.uk/cgi-bin/omd?axotomy "Online Medical Dictionary"]</ref> | ||
Axotomy may cause neuronal cell death, | Axotomy may cause neuronal cell death, especially in [[embryonic]] or [[neonatal]] animals, as this is the period in which [[neuron|neurons]] are dependent on their targets for the supply of survival factors. But in mature animals, where survival factors are derived locally or via [[autocrine]] loops, axotomy of [[peripheral]] neurons and [[Motor neuron|motoneurons]] can lead to a robust regenerative response without any neuronal death. In both cases, [[autophagy]] is observed to markedly increase. Autophagy could either clear the way for neuronal degeneration or it could be a medium for cell destruction.<ref name="Rub">Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045</ref> | ||
== | ==Related Chapters== | ||
* [[Neurectomy]] | * [[Neurectomy]] | ||
* [[Neurosurgery]] | * [[Neurosurgery]] | ||
Latest revision as of 20:33, 29 November 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The process of cutting or to otherwise sever an axon. Derived from axo- (=axon) and -tomy (=surgery). This type of denervation is often used in experimental studies on neuronal physiology and neuronal death or survival as a method to better understand nervous system diseases.[1]
Axotomy may cause neuronal cell death, especially in embryonic or neonatal animals, as this is the period in which neurons are dependent on their targets for the supply of survival factors. But in mature animals, where survival factors are derived locally or via autocrine loops, axotomy of peripheral neurons and motoneurons can lead to a robust regenerative response without any neuronal death. In both cases, autophagy is observed to markedly increase. Autophagy could either clear the way for neuronal degeneration or it could be a medium for cell destruction.[2]
Related Chapters
References
- ↑ "Online Medical Dictionary"
- ↑ Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045
Template:Neurosurgical procedures
 | This cell biology article is a stub. You can help Wikipedia by expanding it. |