Autoimmune hepatitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  :Manpreet Kaur, MD [2]


Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Following laboratory tests are used to diagnose autoimmune hepatitis:

  • Liver function tests
  • Alkaline phosphatase
  • Antibody assays
  • Serum protein and immunoglobulins
  • Complete blood count and differential count
  • Platelet count
  • ESR
  • Coombs test
  • Peripheral blood film

Laboratory findings consistent with the diagnosis of Autoimmune hepatitis include:

  • Increased serum aminotransferase levels (1.5-50 times reference values)
  • Increased serum immunoglobulin levels, primarily immunoglobulin G (1.2 to 3.0 times normal)
  • Seropositive for ANAs, anti-actin, SMAs, LKM-1, anti-liver cytosol 1 (anti-LC1) antibodies, SLA/LP autoantibodies or pANCA
Revised Original Scoring System of the International Autoimmune Hepatitis Group
Laboratory Findings Points
  • AP:AST (or ALT) ratio
    • <1.5
    • 1.5-3
    • >3

+2

0

-2

  • Serum globulin or IgG level above ULN
    • >2.0
    • 1.5-2.0
    • 1.5-1
    • <1

+3

+2

+1

0

  • ANA, SMA, or anti-LKM1
    • >1:80
    • 1:80
    • 1:40
    • <1:40

+3

+2

+1

0

  • AMA positive
-4
  • Hepatitis markers
    • Positive
    • Negative

References

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