Autoimmune hepatitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  :Manpreet Kaur, MD [2]

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Following laboratory tests are used to diagnose autoimmune hepatitis:

• Liver function tests
• Alkaline phosphatase
• Antibody assays
• Serum protein and immunoglobulins
• Complete blood count and differential count
• Platelet count
• ESR
• Coombs test
• Peripheral blood film

Laboratory findings consistent with the diagnosis of Autoimmune hepatitis include:

• Increased serum aminotransferase levels (1.5-50 times reference values)
• Increased serum immunoglobulin levels, primarily immunoglobulin G (1.2 to 3.0 times normal)
• Seropositive for ANAs, anti-actin, SMAs, LKM-1, anti-liver cytosol 1 (anti-LC1) antibodies, SLA/LP autoantibodies or pANCA

Revised Original Scoring System of the International Autoimmune Hepatitis Group
Laboratory Findings	Points
AP:AST (or ALT) ratio <1.5 1.5-3 >3	+2 0 -2
Serum globulin or IgG level above ULN >2.0 1.5-2.0 1.5-1 <1	+3 +2 +1 0
ANA, SMA, or anti-LKM1 >1:80 1:80 1:40 <1:40