Autoimmune hepatitis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Historical Perspective
Discovery
- In 1950, Waldenstrom was the first to describe a form of chronic hepatitis in young women.[1]
- In 1950, Kunkel, and in 1956, Bearn, described features of the disease, including hepatosplenomegaly, jaundice, acne, hirsutism, cushingoid facies, pigmented abdominal striae, obesity, arthritis, and amenorrhea.
- In 1992, an international panel described the diagnostic criteria for Autoimmune hepatitis.
- The term Autoimmune hepatitis was used to replace terms such as Autoimmune liver disease and Autoimmune chronic active hepatitis by an international panel.
- C4 gene mutations were first implicated in the pathogenesis of Autoimmune hepatitis.[2]
Outbreaks
- There have been several outbreaks of [disease name], which are summarized below:
Landmark Events in the Development of Treatment Strategies
- In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
Impact on Cultural History
Famous Cases
- The following are a few famous cases of disease name:
References
- ↑ WALDENSTROM J (1953). "[Liver, blood proteins and nutritive protein]". Dtsch Z Verdau Stoffwechselkr (in Undetermined). 9: 113–9. PMID 13150939.
- ↑ Scully LJ, Toze C, Sengar DP, Goldstein R (1993). "Early-onset autoimmune hepatitis is associated with a C4A gene deletion". Gastroenterology. 104 (5): 1478–84. PMID 8482459.