Autoimmune hepatitis historical perspective: Difference between revisions
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*In 1992, an international panel described the diagnostic criteria for Autoimmune hepatitis. | *In 1992, an international panel described the diagnostic criteria for Autoimmune hepatitis. | ||
*The term Autoimmune hepatitis was used to replace terms such as Autoimmune liver disease and Autoimmune chronic active hepatitis by an international panel. | *The term Autoimmune hepatitis was used to replace terms such as Autoimmune liver disease and Autoimmune chronic active hepatitis by an international panel. | ||
*C4 gene mutations were first implicated in the pathogenesis of Autoimmune hepatitis.<ref name="pmid8482459">{{cite journal |vauthors=Scully LJ, Toze C, Sengar DP, Goldstein R |title=Early-onset autoimmune hepatitis is associated with a C4A gene deletion |journal=Gastroenterology |volume=104 |issue=5 |pages=1478–84 |year=1993 |pmid=8482459 |doi= |url=}}</ref> | *C4 [[gene]] [[mutations]] were first implicated in the [[pathogenesis]] of [[Autoimmune hepatitis]].<ref name="pmid8482459">{{cite journal |vauthors=Scully LJ, Toze C, Sengar DP, Goldstein R |title=Early-onset autoimmune hepatitis is associated with a C4A gene deletion |journal=Gastroenterology |volume=104 |issue=5 |pages=1478–84 |year=1993 |pmid=8482459 |doi= |url=}}</ref> | ||
==Landmark Events in the Development of Treatment Strategies== | ==Landmark Events in the Development of Treatment Strategies== |
Revision as of 17:17, 27 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Historical Perspective
Discovery
- Autoimmune hepatitis was the first to describe early in the 1950s, under the name lupoid hepatitis, which mainly affects young women.[1]
- In 1950, Waldenstrom described a form of chronic hepatitis in young women.[2]
- In 1950, Kunkel, and in 1956, Bearn, described features of the disease, including hepatosplenomegaly, jaundice, acne, hirsutism, cushingoid facies, pigmented abdominal striae, obesity, arthritis, and amenorrhea.
- In 1992, an international panel described the diagnostic criteria for Autoimmune hepatitis.
- The term Autoimmune hepatitis was used to replace terms such as Autoimmune liver disease and Autoimmune chronic active hepatitis by an international panel.
- C4 gene mutations were first implicated in the pathogenesis of Autoimmune hepatitis.[3]
Landmark Events in the Development of Treatment Strategies
- In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
References
- ↑ COWLING DC, MACKAY IR, TAFT LI (1956). "Lupoid hepatitis". Lancet. 271 (6957): 1323–6. PMID 13386250.
- ↑ WALDENSTROM J (1953). "[Liver, blood proteins and nutritive protein]". Dtsch Z Verdau Stoffwechselkr (in Undetermined). 9: 113–9. PMID 13150939.
- ↑ Scully LJ, Toze C, Sengar DP, Goldstein R (1993). "Early-onset autoimmune hepatitis is associated with a C4A gene deletion". Gastroenterology. 104 (5): 1478–84. PMID 8482459.