Atypical teratoid rhabdoid tumor diagnostic study of choice: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the central nervous system criteria, which include presence of rhabdoid tumor cells and/or divergent differentiation along [[epithelial]], [[mesenchymal]], [[neuronal]], or [[glial|glial lines]] in addition to the complete loss of [[SMARCB1]] protein expression in tumor cell nuclei, but the expression retained in preexisting cells (e.g., [[endothelial cells]]). | The [[diagnosis]] of atypical teratoid rhabdoid tumor is based on the current [[World Health Organization|WHO]] ''[[classification]] of [[Tumor|tumors]] of the [[central nervous system]]'' criteria, which include presence of [[Malignant rhabdoid tumor|rhabdoid tumor]] [[Cell (biology)|cells]] and/or divergent differentiation along [[epithelial]], [[mesenchymal]], [[neuronal]], or [[glial|glial lines]] in addition to the complete loss of [[SMARCB1]] [[protein expression]] in [[tumor]] [[Cell (biology)|cell]] [[Cell nucleus|nuclei]], but the expression retained in preexisting [[Cell (biology)|cells]] (e.g., [[endothelial cells]]). | ||
==Diagnostic Study of Choice== | ==Diagnostic Study of Choice== | ||
===Study of Choice=== | ===Study of Choice=== | ||
The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the central nervous system criteria, which include:<ref name="SlavcChocholous2014">{{cite journal|last1=Slavc|first1=Irene|last2=Chocholous|first2=Monika|last3=Leiss|first3=Ulrike|last4=Haberler|first4=Christine|last5=Peyrl|first5=Andreas|last6=Azizi|first6=Amedeo A.|last7=Dieckmann|first7=Karin|last8=Woehrer|first8=Adelheid|last9=Peters|first9=Christina|last10=Widhalm|first10=Georg|last11=Dorfer|first11=Christian|last12=Czech|first12=Thomas|title=Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992-2012|journal=Cancer Medicine|volume=3|issue=1|year=2014|pages=91–100|issn=20457634|doi=10.1002/cam4.161}}</ref> | The [[diagnosis]] of atypical teratoid rhabdoid tumor is based on the current [[World Health Organization|WHO]] ''[[classification]] of [[Tumor|tumors]] of the [[central nervous system]]'' criteria, which include:<ref name="SlavcChocholous2014">{{cite journal|last1=Slavc|first1=Irene|last2=Chocholous|first2=Monika|last3=Leiss|first3=Ulrike|last4=Haberler|first4=Christine|last5=Peyrl|first5=Andreas|last6=Azizi|first6=Amedeo A.|last7=Dieckmann|first7=Karin|last8=Woehrer|first8=Adelheid|last9=Peters|first9=Christina|last10=Widhalm|first10=Georg|last11=Dorfer|first11=Christian|last12=Czech|first12=Thomas|title=Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992-2012|journal=Cancer Medicine|volume=3|issue=1|year=2014|pages=91–100|issn=20457634|doi=10.1002/cam4.161}}</ref> | ||
*Presence of rhabdoid tumor cells and/or divergent differentiation along [[epithelial]], [[mesenchymal]], [[neuronal]], or [[glial|glial lines]] | *Presence of [[Malignant rhabdoid tumor|rhabdoid tumor]] [[Cell (biology)|cells]] and/or divergent differentiation along [[epithelial]], [[mesenchymal]], [[neuronal]], or [[glial|glial lines]] | ||
:{{and}} | :{{and}} | ||
*Complete loss of [[SMARCB1]] protein expression in tumor cell nuclei, but the expression retained in preexisting cells (e.g., [[endothelial cells]]) | *Complete loss of [[SMARCB1]] [[protein expression]] in [[tumor]] [[Cell (biology)|cell]] [[Cell nucleus|nuclei]], but the expression retained in preexisting [[Cell (biology)|cells]] (e.g., [[endothelial cells]]) | ||
==References== | ==References== | ||
Latest revision as of 18:54, 16 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the central nervous system criteria, which include presence of rhabdoid tumor cells and/or divergent differentiation along epithelial, mesenchymal, neuronal, or glial lines in addition to the complete loss of SMARCB1 protein expression in tumor cell nuclei, but the expression retained in preexisting cells (e.g., endothelial cells).
Diagnostic Study of Choice
Study of Choice
The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the central nervous system criteria, which include:[1]
- Presence of rhabdoid tumor cells and/or divergent differentiation along epithelial, mesenchymal, neuronal, or glial lines
- AND
- Complete loss of SMARCB1 protein expression in tumor cell nuclei, but the expression retained in preexisting cells (e.g., endothelial cells)
References
- ↑ Slavc, Irene; Chocholous, Monika; Leiss, Ulrike; Haberler, Christine; Peyrl, Andreas; Azizi, Amedeo A.; Dieckmann, Karin; Woehrer, Adelheid; Peters, Christina; Widhalm, Georg; Dorfer, Christian; Czech, Thomas (2014). "Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992-2012". Cancer Medicine. 3 (1): 91–100. doi:10.1002/cam4.161. ISSN 2045-7634.