Amyloidosis history and symptoms

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Overview

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Classification

Primary amyloidosis
Secondary amyloidosis
Familial amyloidosis
Wild-type (senile) amyloidosis
Cardiac amyloidosis
Beta-2 microglobulin related amyloidosis
Gelsolin related amyloidosis
Lysozyme amyloid related amyloidosis
Leucocyte cell-derived chemotaxin 2 related amyloidosis
Fibrinogen A alpha-chain associated amyloidosis

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Differentiating Amyloidosis from other Diseases

Epidemiology and Demographics

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Natural History, Complications and Prognosis

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History and Symptoms

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[3]

Overview

In amyloidosis, the range of symptoms depends on specific tissues and organs involved.[1] Symptoms can be quite diverse.

History and Symptoms

History

Patients with amyloidosis may have a positive history of:[2]

  • Dyspnea
  • Lethargy
  • Weight loss
  • Chest discomfort
  • Fevers or chills
  • Night sweats

Common Symptoms

Common symptoms in patients with primary amyloidosis include:[2]

  • Bleeding tendency
  • Swelling of lower limbs
  • Frothy urine

Less Common Symptoms

  • Enlarged tongue sensation
  • Abdominal pain
  • Diarrhea
  • Peripheral neuropathy (nerve pain including numbness and tingling)

References

  1. Jerzykowska S, Cymerys M, Gil LA, Balcerzak A, Pupek-Musialik D, Komarnicki MA (2014). "Primary systemic amyloidosis as a real diagnostic challenge - case study". Cent Eur J Immunol. 39 (1): 61–6. doi:10.5114/ceji.2014.42126. PMC 4439975. PMID 26155101.
  2. 2.0 2.1 Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.

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