Amoebic liver abscess pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
'''Variants of amoebic liver abscesses''' | |||
* Solitary lesions (30%-70%) are more common amoebic liver abscesses and most commonly seen in right lobe of the liver. | * Solitary lesions (30%-70%) are more common amoebic liver abscesses and most commonly seen in right lobe of the liver. | ||
1. '''Multiple liver abscesses''' | |||
*15% of patients have multiple liver abscesses | |||
*Presenting features include: | |||
:*Fever | |||
:*Toxaemia | |||
:*Encephalopathy | |||
:*Jaundice | |||
*The most common organisms that cause multiple liver abscesses are ''[[E.coli]]'' and ''[[Klebsilella]]'' | |||
* | |||
Toxaemia | |||
Encephalopathy | |||
Revision as of 19:59, 3 February 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]
Overview
Ameoebic liver abscess is caused by a protozoan Entamoeba histolytica. It is the most common extraintestinal manifestation of amoebiasis.
Pathophysiology
- Amoebic liver abscess is the most common extraintestinal manifestation of amoebiasis.
- There are two genetically different species of entamoeba.[1] They are
- Mode of transmission of Entamoeba histolytica include
- Fecal-oral route (ingestion of food and water contaminated with feces containing cysts)
- Hepatocyte programmed cell death induced by Entamoeba histolytica causes amoebic liver abscess.
- The infection is transmitted to liver by portal venous system.[2]
- Clinical syndromes associated with Entamoeba histolytica infection
| Entamoeba histolytica | |||||||||||||||||||||||||||||||||||||||||||||||
| Intestinal amoebiasis •Asymptomatic cyst passers •Acute amoebic colitis - Mucosal disease - Transmural disease - Ulcerative postdysentric colitis *Appendicitis *Amoeboma *Amoebic stricture | Extra intestinal amoebiasis *Amoebic Liver abscess *Perforation and peritonitis *Pleuropulmonary amoebiasis *Amoebic pericarditis *Cutaneous Amoebiasis | ||||||||||||||||||||||||||||||||||||||||||||||
Pathogenesis
Variants of amoebic liver abscesses
- Solitary lesions (30%-70%) are more common amoebic liver abscesses and most commonly seen in right lobe of the liver.
1. Multiple liver abscesses
- 15% of patients have multiple liver abscesses
- Presenting features include:
- Fever
- Toxaemia
- Encephalopathy
- Jaundice
- The most common organisms that cause multiple liver abscesses are E.coli and Klebsilella
- ↑ Gonin P, Trudel L (2003). "Detection and differentiation of Entamoeba histolytica and Entamoeba dispar isolates in clinical samples by PCR and enzyme-linked immunosorbent assay". J Clin Microbiol. 41 (1): 237–41. PMC 149615. PMID 12517854.
- ↑ Aikat BK, Bhusnurmath SR, Pal AK, Chhuttani PN, Datta DV (1979). "The pathology and pathogenesis of fatal hepatic amoebiasis--A study based on 79 autopsy cases". Trans. R. Soc. Trop. Med. Hyg. 73 (2): 188–92. PMID 473308.